Medicinal agents incorporating the 1,2-diamine functionality

The Chemistry of Vicinal Diamines

“…In 1989 Michalson and Szmuszkovicz reviewed medicinal agents incorporating the 1,2-diamine unit. [5] Among them we can cite, for instance, antiarrhythmics, [6] antidepressant agents, [7] antihypertensives, antipsychotics, analgesics, anti- anxiety agents, anticancer drugs, and antiparasitic agents. Some important and illustrative examples will be described in this section.…”

Cinchonidinium acetate as a convenient catalyst for the asymmetric synthesis of cis-stilbenediamines

“…1 Moreover, this array serves as the critical stereocontrol element in a substantial percentage of both organo- and metal-based asymmetric catalysts. 2 Despite their utility, asymmetric methods for the synthesis of several classes of vicinal diamines remains challenging, often relying on chiral resolutions.…”

The first reported fatality associated with the synthetic opioid 3,4‐dichloro‐N‐[2‐(dimethylamino)cyclohexyl]‐N‐methylbenzamide (U‐47700) and implications for forensic analysis

“…[10,11] A variety of cyclohexyl trans-1,2-diamines have been found to be potent analgesics and the vicinal 1,2-diamine pattern has provided access to a large range of substances with diverse biological activities. [12][13][14] Since U-47700 did not progress to clinical trials, there is no direct clinical information pertaining to its effects. Keeping in mind the various limitations that may be associated with descriptions obtained from self-reporting users, its effects have been described with various positive and negative symptoms but appeared to be essentially comparable to other opioids.…”