2018
DOI: 10.1001/jama.2018.10061
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Medications for Alcohol Use Disorder and Predicting Severe Withdrawal

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Cited by 8 publications
(8 citation statements)
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“…Moreover, experiencing a DER seems not to be associated with any differences in treatment outcome but with a significant earlier discontinuation of DIS therapy [47]. Other publications [1,3,4] concluded that PLOS ONE the drug is valuable but in these, adequate supervision was guaranteed. In this respect immediate recognition and treatment of a DER in the ED is an important aspect of DIS therapy.…”
Section: Discussionmentioning
confidence: 99%
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“…Moreover, experiencing a DER seems not to be associated with any differences in treatment outcome but with a significant earlier discontinuation of DIS therapy [47]. Other publications [1,3,4] concluded that PLOS ONE the drug is valuable but in these, adequate supervision was guaranteed. In this respect immediate recognition and treatment of a DER in the ED is an important aspect of DIS therapy.…”
Section: Discussionmentioning
confidence: 99%
“…Disulfiram (DIS) is primarily used as an adjunct in the treatment of alcohol use disorders [1][2][3][4]. DIS and its active metabolite S-methyl N,N-diethylthiocarbamate sulfoxide irreversibly inhibit the enzyme aldehyde dehydrogenase which leads to the accumulation of acetaldehyde with effects known as a DIS ethanol reaction (DER) [5,6].…”
Section: Introductionmentioning
confidence: 99%
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“…This sentiment is not a deviation of care as these medications have been discussed in other prominent medical journals regarding pharmacotherapy for alcohol use disorder, including the New England Journal of Medicine 4 and the Journal of American Medical Association. 5,6 Finally, the authors note that a reduction in drinking alone is a nonvalid surrogate. We are aware of the recommendation of the American Institute of Cancer Research for total abstinence from alcohol stemming from the current literature, which suggests a causal link between US dietary guidelineebased moderate alcohol consumption and cancer.…”
mentioning
confidence: 98%
“…As a general rule, off-label use is about caveats, not promises: (1) exposing patients to the unnecessary risk of many adverse events, including mortality, for an all-too-often uncertain efficacy, 5 and (2) hindering the development of evidence-based medicine and therapeutic innovation.…”
mentioning
confidence: 99%