Seafood is a common cause of food allergy. Allergic reactions are reported by consumers jollowing ingestion of seafood meat and by processing workers after occupational tlxposure to seafood by inhalation of vapors generated during cooking. Although .yeafood allergy is commonly observed in clinical practice, its precise prevalence is not established. Based on our estimates, approximately 100,OOO to 250,000 Americans are at risk of developing allergic reactions to seafoodproducts. In this study, skin testing, in vitro assays and double-blind, placebocontrolled food challenge were employed to investigate seafood allergy in shrimpallergic individuals. As in most food allergy studies only I N of the alleged shrimpsensitive subjects had a positive shrimp challenge test. f i e combination of a positive shrimp skin test and shrimp RAST (> 11 % bound) had the best predictive value (87%) for a positive challenge response. Although occupational seafood allergy is not well-studied, based on a Canadian investigation, it can be estimated that 57,000 American seafood workers are at risk of developing work-related allergic reactions. Since seafood is a major food allergen in consumers and industrial workers, jiuther studies are necessary. Despite developments of new antiallergic therapies, avoidance continues to be the best "treatment "for allergic ingestive, inhalative and occupational disease. 'Reprints requests; should be directed to: