Medication Use in the Neonatal Intensive Care Unit: Current Patterns and Off-Label Use of Parenteral Medications

Prabhash, Kumar; Walker, Jennifer K.; Hurt, Kristin M.; Bennett, Kimberly M.; Grosshans, Neal; Fotis, Michael A.

doi:10.1016/j.jpeds.2007.07.050

Cited by 84 publications

(100 citation statements)

References 15 publications

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“…Data of the neonates such as age, gender, In present study, among the patients, 119 (62.96%) were males while 70 (37.03%) were females. This is in contrast to the studies of Kumar et al 6 and Neubert et al 7 who reported 57% and 55.7% of admission of male neonates, respectively. This study showed that out of 189 patients admitted, 42.32% patients were pre-terms and 57.67% were full terms, while Neubert et al (2009) 7 have reported admission of 69% preterm infants.…”

Section: Discussioncontrasting

confidence: 90%

“…In previous studies, mean duration of stay in NICU was 17±16.4 days and 21.1±24.8 days respectively. 6,9 Results in our study may reflect appropriate antimicrobial prescriptions in our NICU or earlier discharge of patients as compared to other studies as undue prolongation of hospitalization may itself increases chances of nosocomial infection in neonates.…”

Section: Discussionmentioning

confidence: 52%

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Drug utilization study of antimicrobial agents in patients of neonatal sepsis in neonatal intensive care unit at a tertiary care hospital in western part of India

Amin

Shah

Asari

et al. 2015

Int J Basic Clin Pharmacol

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Section: Discussioncontrasting

confidence: 90%

Section: Discussionmentioning

confidence: 52%

Drug utilization study of antimicrobial agents in patients of neonatal sepsis in neonatal intensive care unit at a tertiary care hospital in western part of India

Amin

Shah

Asari

et al. 2015

Int J Basic Clin Pharmacol

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“…For example, some European reviews have indicated that over 50% of all neonatal ICU patients received off-label or an unlicensed prescription [7]. Several studies correlated multiple factors with mortality and duration of hospitalization in the ICU.…”

Section: Introductionmentioning

confidence: 99%

Drug Utilization Pattern in an Intensive Care Unit at a Tertiary Care Teaching Hospital in Oman

Al‐Zakwani

Al-thuhli

Al-Hashim

et al. 2017

Asian J Pharm Clin Res

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Objectives: The objective of this study was to evaluate the drug prescribing trends in the intensive care unit (ICU) and correlate them with the disease patterns and patients' outcomes. Methods:The case records of patients admitted to the ICU at Sultan Qaboos University Hospital, a teaching hospital in Oman, during a 5-month period between June 1 st and October 31 st 2013 were analyzed. The variables collected included demographic and clinical characteristics as well as duration of hospitalization, indications, and utilization of different drugs.Results: A total of 138 patients were evaluated with an average age of 46±19 years. The average length of stay at ICU was 4.5±3.5 days. The average number of drugs per prescription was 8.0±4.6. The most common route used was the parenteral route (66%) followed by the enteral route (25%).

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“…Moreover, the use of certain drugs in some NICUs may be an "off-label" means beyond the approved indication, and also their safety not being clearly established in high-risk neonates [5,6].…”

Section: Introductionmentioning

confidence: 99%

Drug Utilization Study in Neonatal Intensive Care Unit at Rural Tertiary Care Hospital.

Choure¹,

Jadhav

Padwal

2017

Asian J Pharm Clin Res

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Objectives: To study the trends of drug utilization pattern in neonatal intensive care unit (NICU) at rural tertiary care hospital using the World Health Organization core indicators. Methods:The study was cross-sectional, observational study in NICU of Government Medical College, Ambajogai, Maharashtra. Data were collected by scrutinizing the prescriptions written by pediatricians in NICU. The consent of parents of neonate was obtained for inclusion in the study. Parameters such as age, gender, birth weight, current illness, congenital anomalies, gestational age at birth, and drugs prescription analyzed. Results:A total 220 prescription were scrutinized. Out of 220 neonates, 53.6% was males and 46.3% females. The total number of drugs prescribed was 808 and the average number of drugs per prescription was 3.6. The most frequently prescribed therapeutic class of drugs antimicrobial agents (60.64%) followed by vitamin K (26.7%) and aminophylline (9.4%). The maximum number (50%) of neonate born with birth weight <2.5. The maximum number (42%) of neonate was born at 34-36 weeks of gestation. Preterm low birth weight was the most common observed reason for admission to NICU. The drugs are prescribed by branded name outnumbered than generic name. Conclusion:This study highlights the problem of overprescribing of antibiotics, inadequate labeling and a trend toward polypharmacy.

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Medication Use in the Neonatal Intensive Care Unit: Current Patterns and Off-Label Use of Parenteral Medications

Cited by 84 publications

References 15 publications

Drug utilization study of antimicrobial agents in patients of neonatal sepsis in neonatal intensive care unit at a tertiary care hospital in western part of India

Drug utilization study of antimicrobial agents in patients of neonatal sepsis in neonatal intensive care unit at a tertiary care hospital in western part of India

Drug Utilization Pattern in an Intensive Care Unit at a Tertiary Care Teaching Hospital in Oman

Drug Utilization Study in Neonatal Intensive Care Unit at Rural Tertiary Care Hospital.

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