Medication Use and Risk of Non-Hodgkin's Lymphoma

Chang, Ellen T.; Smedby, Karin E.; Hjalgrim, Henrik; Schöllkopf, Claudia; Porwit‐MacDonald, Anna; Sundström, Christer; Tani, Ednéia; d’Amore, Francesco; Melbye, Mads; Adami, Hans‐Olov; Glimelius, Bengt

doi:10.1093/aje/kwi311

Cited by 42 publications

(47 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Few other studies examined NSAID use and NHL subtypes. One case-control study reported a positive association between long-term, regular NSAID use and DLBCL only (17), whereas another reported a lower risk of several NHL subtypes with 4 or more consecutive weeks of NSAID use (8).…”

Section: Discussionmentioning

confidence: 99%

“…However, results of epidemiologic studies of nonsteroidal anti-inflammatory drugs (NSAIDs) in relation to non-Hodgkin lymphoma (NHL) are inconsistent. Positive, negative, and null associations have been reported, with some studies reporting an association with all NSAIDs, whereas others with just aspirin or nonaspirin NSAIDs (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Most studies had limited statistical power, particularly for detailed analyses by frequency, duration, and type of NSAID use, and/or NHL subtype.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Aspirin and Other Nonsteroidal Anti-Inflammatory Drugs and Risk of Non-Hodgkin Lymphoma

Teras

Gapstur

Patel

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Few large prospective studies have examined associations between nonsteroidal anti-inflammatory drug (NSAID) use and non-Hodgkin lymphoma (NHL). We examined the association between NSAID use and NHL incidence among 149,570 participants in the Cancer Prevention Study-II Nutrition cohort. Aspirin and nonaspirin NSAID use were reported at enrollment in 1992 and updated on periodic follow-up questionnaires. During follow-up through 2007, 1,709 incident NHLs were identified. Time-dependent hazard ratios were calculated using extended Cox regression. Compared to no use, current use of 60þ NSAID pills/month (aspirin and nonaspirin NSAIDs combined) was associated with slightly higher NHL incidence (hazard ratio [HR] ¼ 1.26, 95% confidence interval [CI], 1.04-1.53), but no association with frequency of use was observed when NSAID exposure was lagged by approximately 2 years (HR ¼ 1.08, 95% CI, 0.88-1.32). Long duration regular use (current use of 30þ pills/month for 5 years) was not associated with NHL incidence (HR ¼ 1.09, 95% CI, 0.91-1.33). In subtype analyses, current use of 60þ NSAID pills/month was associated with follicular lymphoma incidence (HR ¼ 1.87, 95% CI, 1.08-3.24). This association persisted when NSAID exposure was lagged (HR ¼ 1.76, 95% CI, 1.04-2.98) and was similar for aspirin and nonaspirin NSAIDs. The association of current, but not lagged, NSAID use with risk of all NHL could be attributable to use of NSAIDs to relieve symptoms of undiagnosed NHL. However, the association with follicular lymphoma persisted in analyses where NSAID use was lagged and should be investigated further. These findings are particularly important for aspirin as the risks and benefits of prophylactic daily use are weighed. Cancer Epidemiol Biomarkers Prev; 22(3);

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Aspirin and Other Nonsteroidal Anti-Inflammatory Drugs and Risk of Non-Hodgkin Lymphoma

Teras

Gapstur

Patel

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

show abstract

“…647 A subsequent study in Sweden found a marginally significant excess risk of T-cell lymphoma (OR 5 3.6, 95% CI: 1.0-12.8), but not of overall NHL (OR 5 1.2, 95% CI: 0.6-2.5), among phenytoin users. 648 Similarly, other case-control studies have not reported significant associations of overall NHL risk with use of dilantin or anticonvulsant drugs. 20,462,548 Significant positive associations were reported with use of cimetidine, a histamine 2 receptor antagonist used to treat gastroesophageal disorders including ulcers, in 2 case-control studies conducted in San Francisco (OR range: 2.3-4.6).…”

Section: Medication Usementioning

confidence: 94%

“…Chang et al 648 found a positive trend in risk of NHL and both B-and T-cell types associated with lifetime frequency of antibiotic use (OR for overall NHL associated with antibiotic use 11 times vs. never: 1.7, 95% CI: 1.3-2.1; p for trend < 0.001). The authors interpreted this association as more likely because of frequent infections or underlying susceptibility to infections, rather than a direct lymphomagenic effect of antibiotics themselves.…”

Section: Medication Usementioning

confidence: 99%

The non-Hodgkin lymphomas: A review of the epidemiologic literature

et al. 2007

Self Cite

View full text Add to dashboard Cite

“…Moreover, chronic infections treated with antibiotics, such as tuberculosis, have been associated with NHL (Swerdlow, 2003). While case -control studies of self-reported antibiotic use have found a 30 -90% increased risk of NHL (Bernstein and Ross, 1992;Kato et al, 2003;Chang et al, 2005), no associations were observed in case -control studies utilising pharmacy (Beiderbeck et al, 2003) or medical record data (Doody et al, 1996). We investigated the association between NHL and antibiotics in a large multicentre case -control study (1998 -2000) within the United States.…”

mentioning

confidence: 98%