Medication therapy strategies for the coronavirus disease 2019 (COVID-19): recent progress and challenges

Yang, Xiaolei; Liu, Ye; Liu, Yuping; Yang, Qing; Wu, Xubo; Huang, Xuan; Liu, Huijia; Cai, Weimin; Ma, Guoyi

doi:10.1080/17512433.2020.1805315

Cited by 10 publications

(6 citation statements)

References 103 publications

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“… 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 We excluded 19 CPGs (eFigure in Supplement 1 ). 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 Of the 32 included CPGs, 3 (9.4%) 15 , 38 , 40 reported on pharmacologic treatments for critically ill patients specifically, and the remainder reported on treatments for hospitalized patients with COVID-19. Fifteen CPGs (46.9%) were international 15 , 16 , …”

Section: Resultsmentioning

confidence: 99%

“…We excluded 19 CPGs (eFigure in Supplement 1). [45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63] Of the 32 included CPGs, 3 (9.4%) 15,38,40 reported on pharmacologic treatments for critically ill patients specifically, and the remainder reported on treatments for hospitalized patients with COVID-19. Fifteen CPGs (46.9%) were international 15,16,20,21,23,24,27,[31][32][33][34]36,38,43,44 and 17 (53.1%) were national.…”

Section: Cpg Identification and Quality Assessmentmentioning

confidence: 99%

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Adherence of Clinical Practice Guidelines for Pharmacologic Treatments of Hospitalized Patients With COVID-19 to Trustworthy Standards

et al. 2021

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Key Points Question Do clinical practice guidelines (CPGs) that report on pharmacologic treatments of hospitalized patients with COVID-19 meet the National Academy of Medicine standards for trustworthiness? Findings In this systematic review of 32 CPGs of predominantly low quality, few reported funding sources or conflicts of interest, included a methodologist, described a search strategy or study selection process, or synthesized evidence. Although 14 CPGs (43.8%) made recommendations or suggestions for or against treatments, they infrequently rated the confidence in the quality of the evidence (6 [18.8%]), described potential benefits and harms (6 [18.8%]), or graded the strength of recommendations (5 [15.6%]). Meaning The findings of this study suggest that few COVID-19 CPGs meet National Academy of Medicine standards for trustworthy guidelines.

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Section: Resultsmentioning

confidence: 99%

Section: Cpg Identification and Quality Assessmentmentioning

confidence: 99%

Adherence of Clinical Practice Guidelines for Pharmacologic Treatments of Hospitalized Patients With COVID-19 to Trustworthy Standards

et al. 2021

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“…However, another observation was that after their COVID-19 infection most patients developed hypoxia, a condition where an individual has an alarming low oxygen saturation level of about 50–80% saturation [ 41 ]. In contrast, the expected saturation level is ≥95% with the patients not experiencing any difficulties in breathing [ 42 , 43 ]. This phenomenon resulted in patients becoming severely ill, especially when accompanied by a lack of dyspnea and extremely low oxygen saturation levels.…”

Section: Discussionmentioning

confidence: 99%

Health System- and Patient-Related Factors Associated with COVID-19 Mortality among Hospitalized Patients in Limpopo Province of South Africa’s Public Hospitals

et al. 2022

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South Africa has recorded the highest COVID-19 morbidity and mortality compared to other African regions. Several authors have linked the least amount of death in African countries with under-reporting due to poor health systems and patients’ health-seeking behaviors, making the use of clinical audits more relevant for establishing the root causes of health problems, and improving quality patient care outcomes. Clinical audits, such as mortality audits, have a significant role in improving quality health care services, but very little is documented about the outcomes of the audits. Therefore, the study sought to determine the health care system and patient-related factors associated with COVID-19 mortality by reviewing the COVID-19 inpatient mortality audit narration reports. This was a retrospective qualitative research approach of all hospitalized COVID-19 patients, resulting in death between the first and second COVID-19 pandemic waves. Thematic analysis employed inductive coding to identify themes from mortality audits from all 41 public hospitals in Limpopo Province, South Africa. Four themes with seventeen sub-themes emerged: sub-standard emergency medical care provided, referral system inefficiencies contributed to delays in access to health care services, the advanced age of patients with known and unknown comorbidities, and poor management of medical supplies and equipment, as a health system and patient-related factors that contributed to the high mortality of COVID-19 patients. There is a need to routinely conduct clinical audits to identify clinical challenges and make recommendations for health promotion, risk communication, and community engagement. We recommend reviewing and expanding the scope of practice for health-care providers during epidemics and pandemics that include aspects such as task-shifting.

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“…There are certain emerging therapies to cope with the infections. Hydroxychloroquine, Chloroquine, Lopinavir/ritonavir and Remdesivir have antiviral activity that can control SARS-CoV-2 in-vitro [32]; moreover, Viral entry inhibitors, ACE2 modulators (angiotensin receptor blockers) and TMPRSS2 inhibitors (camostat mesylate) are promising clinical drugs, and it has suggested that Shuanghuanglian oral liquid and Lianhuaqingwen are effective for certain patients with COVID-19 in China [18,33,34]. Given the high level of cytokines in the host, the immunosuppressive drugs targeting the interleukin-6 (IL-6) receptor, tocilizumab are reported to treat COVID-19-related cytokine storms [35], and the application of blood puri cation technology (plasma exchange, blood/plasma ltration, adsorption, perfusion and continuous renal replacement therapy) is helpful to the removal of cytokines and may be bene cial to improve the clinical outcome of critically ill patients [20].…”

Section: Discussionmentioning

confidence: 99%

From Skirmishes to Protracted Battles: A Bibliometric Analysis About Human Beings and Coronaviruses From 1991 to 2020

Yue

et al. 2020

Preprint

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Background: COVID-19 caused unprecedented literature upsurge, and the world has worked together to fight the epidemic.Methods: We conducted a bibliometric analysis to evaluate the research trends and reveal the core contents, based on publication outputs, geographical distribution, collaborations and hot keywords.Results: Our analysis revealed the following: (1) The publication outputs obviously increased after SARS and MERS outbreaks, while sharply on rise during COVID-19 outbreak. Compared with SARS and MERS, COVID-19 aroused more dramatic and prolonged upsurge. (2) Compared with SARS and MERS, COVID-19 caused more widespread and powerful influences on countries or territories at short notice. Countries or territories displayed more international collaborations and communications to cope with the epidemics, and COVID-19 remarkably boosted the research advancements. (3) Given the keywords, we identified that multiple optional methods were used to cope with the SARS-CoV-2 infection based on the features of biology and immune responses.Conclusions: Epidemics extremely accelerated the research boom and evolution.

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Medication therapy strategies for the coronavirus disease 2019 (COVID-19): recent progress and challenges

Cited by 10 publications

References 103 publications

Adherence of Clinical Practice Guidelines for Pharmacologic Treatments of Hospitalized Patients With COVID-19 to Trustworthy Standards

Adherence of Clinical Practice Guidelines for Pharmacologic Treatments of Hospitalized Patients With COVID-19 to Trustworthy Standards

Health System- and Patient-Related Factors Associated with COVID-19 Mortality among Hospitalized Patients in Limpopo Province of South Africa’s Public Hospitals

From Skirmishes to Protracted Battles: A Bibliometric Analysis About Human Beings and Coronaviruses From 1991 to 2020

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