Medication screening for smoking cessation: a proposal for new methodologies

Perkins, Kenneth A.; Stitzer, Maxine L.; Lerman, Caryn

doi:10.1007/s00213-005-0105-5

Cited by 87 publications

(110 citation statements)

References 62 publications

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“…For example, nicotine patch did not signifi cantly reduce total withdrawal, consistent with other studies of briefl y abstinent smokers not trying to quit permanently ( Teneggi et al, 2002 ; see also Perkins, Stitzer, & Lerman, 2006 ) but contrary to most clinical trial results ( Jorenby, Keehn, & Fiore, 1995 ). Moreover, analyses of abstinence effects by time of day were limited to the participants who self-selected to abstinence during the patch weeks, as with all cessation studies, including all outpatient and some inpatient studies of enforced abstinence (since not all are able to abstain even when paid to do so; e.g., Juliano, Donny, Houtsmuller, & Stitzer, 2006 ).…”

Section: Discussionsupporting

confidence: 86%

Severity of tobacco abstinence symptoms varies by time of day

Perkins¹,

Briski²,

Fonte³

et al. 2009

Nicotine &Amp; Tobacco Research

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Section: Discussionsupporting

confidence: 86%

Severity of tobacco abstinence symptoms varies by time of day

Perkins¹,

Briski²,

Fonte³

et al. 2009

Nicotine &Amp; Tobacco Research

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“…The smokers in the study were also non-treatment seeking, which could feasibly limit the study's real-world validity. However, others have found that monetary compensation is an effective alternate reinforcer in providing motivation to resist smoking (Perkins et al, 2006;Gilbert et al, 1999), andMcKee et al (2012) found that treatment seeking status did not affect performance on this lapse task. Furthermore, the smoking cues (i.e., cigarettes and lighter) that are presented during the McKee paradigm may limit the ability of this task to identify risk factors that are predictive of lapse in the real-world.…”

Section: Discussionmentioning

confidence: 90%

Predictors of smoking lapse in a human laboratory paradigm

et al. 2014

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Rationale During a smoking quit attempt, a single smoking lapse is highly predictive of future relapse. While several risk factors for a smoking lapse have been identified during clinical trials, a laboratory model of lapse was until recently unavailable and, therefore, it is unclear whether these characteristics also convey risk for lapse in a laboratory environment. Objectives The primary study goal was to examine whether real-world risk factors of lapse are also predictive of smoking behavior in a laboratory model of smoking lapse. Methods After overnight abstinence, 77 smokers completed the McKee smoking lapse task, in which they were presented with the choice of smoking or delaying in exchange for monetary reinforcement. Primary outcome measures were the latency to initiate smoking behavior and the number of cigarettes smoked during the lapse. Several baseline measures of smoking behavior, mood, and individual traits were examined as predictive factors. Results Craving to relieve the discomfort of withdrawal, withdrawal severity, and tension level were negatively predictive of latency to smoke. In contrast, average number of cigarettes smoked per day, withdrawal severity, level of nicotine dependence, craving for the positive effects of smoking, and craving to relieve the discomfort of withdrawal were positively predictive of number of cigarettes smoked. Conclusions The results suggest that real-world risk factors for smoking lapse are also predictive of smoking behavior in a laboratory model of lapse. Future studies using the McKee lapse task should account for between subject differences in the unique factors that independently predict each outcome measure.

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“…Although this study was conducted using a double blind procedure for alcohol content, a no-alcohol beverage control should be included in future research to control for possible expectancy effects. Third, subjects were not treatment seeking which has been a criticism of laboratory studies examining various smoking cessation medication effects (see Perkins et al 2006). However, money was provided as an alternative reinforcer in order to provide some incentive for not smoking and to enhance the likelihood that the effects of alcohol on the relative reinforcing value of tobacco would be detected (see Higgins, 1997;Rodefer et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

“…However, money was provided as an alternative reinforcer in order to provide some incentive for not smoking and to enhance the likelihood that the effects of alcohol on the relative reinforcing value of tobacco would be detected (see Higgins, 1997;Rodefer et al, 1997). Perkins et al (2006) and others (Stitzer et al, 1986;Gilbert et al, 1999) acknowledge that motivation to abstain can be temporarily raised through the use of monetary reinforcement.…”

Section: Discussionmentioning

confidence: 99%

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Modeling the effect of alcohol on smoking lapse behavior

et al. 2006

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The primary aim of this project was to examine the role of alcohol use in smoking lapse behavior, as alcohol consumption is a known risk factor for poor smoking cessation outcomes. We have developed a novel human laboratory model to examine two primary aspects of alcohol-mediated tobacco relapse: 1) Does alcohol facilitate the initiation of the first cigarette? 2) Once the first cigarette is initiated, does alcohol facilitate subsequent smoking? Using a within-subject design, 16 daily smokers who were also heavy social drinkers received a priming drink (0.03 g/dl or taste masked placebo) and then had the option of initiating a tobacco self-administration session or delaying initiation by five minute increments for up to 50 minutes in exchange for monetary reinforcement. Subsequently, the tobacco self-administration session consisted of a one-hour period, in which subjects could choose to smoke their preferred brand of cigarettes using a smoking topography system or receive monetary reinforcement for cigarettes not smoked. Alcohol craving, tobacco craving, subjective reactivity to alcohol, and nicotine withdrawal were assessed as secondary outcomes. Results demonstrated that after consuming the alcohol beverage, subjects were less able to resist the first cigarette and initiated their smoking sessions sooner, and smoked more cigarettes compared to the placebo beverage. These findings have implications for smoking cessation in alcohol drinkers and model development to assess smoking lapse behavior. Keywordssmoking; lapse behavior; alcohol; craving; human laboratory; monetary reinforcement It is well established that alcohol consumption and tobacco use are highly correlated in both clinical and non-clinical samples. Among alcoholics, 80% to 95% are smokers (DiFranza & Guerrera, 1990;Hughes, 1993;Kalman et al., 2005;Patten et al., 1996;Sobell et al., 1990), as compared to 23% in the general population (CDC, 2003 (DiFranza & Guerrera, 1990;Grant et al., 2004;Hurt et al., 1994) and the severity of alcohol and tobacco dependence is positively correlated (Ellingstad et al., 1999;Gulliver et al., 1995). Smoking is also highly correlated with drinking in nonalcoholic individuals (Carmody et al., 1985;Istvan & Matarazza, 1984), particularly among those who are heavy drinkers. Both laboratory studies and naturalistic observations have demonstrated that alcohol consumption is strongly associated with increased rates of smoking (Glautier et al., 1996;Mitchell et al., 1995;Shiffman et al., 1994). Additionally, there is evidence for cross-substance craving from both clinical and non-clinical samples (Drobes et al., 2000;Tiffany, 1995). Given the high co-occurrence of alcohol and tobacco use, it is not surprising that alcohol has been identified as a risk factor for poor smoking cessation outcomes (Baer & Lichenstein, 1988;Shiffman 1986;Zimmerman et al., 1990). For example, Shiffman (1986) found that 20% of all relapse episodes in smokers involved alcohol consumption. In a real-time examination of first lapse episodes, ...

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Medication screening for smoking cessation: a proposal for new methodologies

Cited by 87 publications

References 62 publications

Severity of tobacco abstinence symptoms varies by time of day

Severity of tobacco abstinence symptoms varies by time of day

Predictors of smoking lapse in a human laboratory paradigm

Modeling the effect of alcohol on smoking lapse behavior

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