Medication‐related problems and adverse drug reactions in Ethiopia: A systematic review

Kefale, Belayneh; Degu, Amsalu; Tegegne, Gobezie Temesgen

doi:10.1002/prp2.641

Cited by 18 publications

(18 citation statements)

References 46 publications

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“…Thus far only a few studies have investigated medicinal plant use [3,19,[147][148][149] and prescription medicine use or self-medication practice during pregnancy [28,38,47,[150][151][152][153][154] in Ethiopia, however, all were conducted among outpatient women, mainly in their early stage of pregnancy, and failed to capture the full picture of use of the various treatment modalities in the entire pregnancy. Likewise, though some MRP identification studies have been conducted among inpatients so far in Ethiopia [155][156][157][158][159], all have focused on the non-pregnant patient population. Thus far, no study has investigated MRPs in pregnant and lactating inpatients in a hospital setting in Ethiopia.…”

Section: Rationale Of the Studymentioning

confidence: 99%

“…Particularly, studies have indicated that chronic disease patients are more likely to use multiple medications making them prone to drug-drug interactions predisposing women to MRPs [159]. Therefore, intervention measures to reduce the harmful effects of medicines and herbs on pregnancy should consider this interrelated nature of predictor and outcome variables and focus on these prioritized areas.…”

Section: Factors Associated With Use Of Treatment Modalities and Mrpsmentioning

confidence: 99%

See 1 more Smart Citation

The use of medicinal plants by pregnant women in Africa: A systematic review

Ahmed

Nordeng

Sundby

et al. 2018

Journal of Ethnopharmacology

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Section: Rationale Of the Studymentioning

confidence: 99%

Section: Factors Associated With Use Of Treatment Modalities and Mrpsmentioning

confidence: 99%

The use of medicinal plants by pregnant women in Africa: A systematic review

Ahmed

Nordeng

Sundby

et al. 2018

Journal of Ethnopharmacology

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“…The most important independent factor underlying non-compliance to treatment is adverse events of medications ( Resende and Santos-Neto, 2015 ; Merid et al, 2019 ; Sankar et al, 2021 ). The overall incidence of ADEs caused by anti-TB medications ranges from 5.1% to 83.5% in different populations ( Kefale et al, 2020 ). ADEs increase patient suffering and increase substantial additional costs because of added outpatient visits, laboratory investigations, and hospitalizations, in more serious instances ( Resende and Santos-Neto, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Assessment of Adverse Drug Events, Their Risk Factors, and Management Among Patients Treated for Multidrug-Resistant TB: A Prospective Cohort Study From Pakistan

Khan

et al. 2022

Front. Pharmacol.

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Background: Multidrug-resistant tuberculosis (MDR-TB) is a growing public health problem. Treatment regimens used against MDR-TB are costly, prolonged, and associated with more side effects as compared with the drug-susceptible tuberculosis. This study was framed to determine the incidence of adverse drug events, risk factors, and their management in MDR-TB patients.Methods: This prospective follow-up cohort study was conducted at the site of programmatic management of drug-resistant TB located at the Pakistan Institute of Medical Sciences, Islamabad. All patients, irrespective of their age, gender, and ethnicity, were included in the study. Adverse drug events were observed in patients at different time points during the study. Patients enrolled for the treatment from January 2018 were prospectively followed till December 2020 up to their end treatment outcomes.Results: Out of 126 MDR-TB patients enrolled for treatment, 116 met the inclusion criteria and were included in the final analysis. Most patients (50.9%) were between 18 and 45 years of age. A minimum of one adverse event was experienced by (50.9%) patients. Of all the adverse events, gastrointestinal disorders were more frequent (47.4%), followed by arthralgia (28.4%) and psychiatric disturbance (20.6%). Furthermore, multivariate analysis showed a significant association with the incidence of adverse events in patients with age group above 60 years (odds ratio (OR) 4.50; 95% CI 1.05-19.2), active smokers (OR 4.20; 95% CI 1.31-13.4), delayed reporting to the TB center (OR 4.03; 95% CI 1.34-12.1), and treatment without bedaquiline regime (OR 3.54; 95% CI 1.23-10.1). Most of the patients (94.6%), counseled by the pharmacist, were found to be satisfied with the information provided and looked for more pharmacist counseling opportunities in the management of MDR-TB.Conclusion: Current findings recommend that ADEs might be well managed by timely identification and reporting. Bedaquiline coupled with other active medications lowered the chance of ADEs in MDR-TB patients. Elderly patients, active smoking behavior, and those who have a delay in the treatment initiation are more prone to ADEs. Clinical pharmacist’s contribution to TB control programs may help caregivers and patients concerning the rational use of medication, early detection, and management of ADEs.

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“…[2][3][4][5][6][7][8][9] According to a systematic review on the prevalence of medicationrelated problems and ADRs, the overall median prevalence of ADRs in Ethiopia is 36.6% with a range of 10.0 to 85.7%. 10 A prospective cross-sectional study conducted in Southwest Ethiopia also reported that ADRs were a common cause of hospitalization and are a reason for the high in-hospital mortality rate. 11 Maintaining and monitoring drugs efficacy and safety is a critical point in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

Knowledge, Attitude, and Practice of Medical, Pharmacy, and Nursing Students Towards Pharmacovigilance and Adverse Drug Reaction Reporting at University of Gondar College of Medicine and Health Sciences, Northwest Ethiopia: A Cross-Sectional Study

Tekel¹,

Bekalu²,

Sema³

2021

AMEP

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Background The adequate knowledge, attitude, and practice (KAP) of pharmacovigilance and ADRs reporting is crucial for health care students. Objective This study aimed at assessing the KAP of final-year medical, pharmacy, and nursing (MPN) students towards pharmacovigilance and ADRs reporting at the University of Gondar, College of Medicine and Health Sciences, Northwest Ethiopia. Methods A cross-sectional study was conducted among 296 final-year MPN students at the University of Gondar College of Medicine and Health Sciences from November 1, 2020 to January 30, 2021. A close-ended, structured, self-administered questionnaire was used for data collection prospectively. SPSS ® (IBM Corporation) version 24 was used to analyze the data with descriptive and inferential statistics. The comparison of the KAP of groups was made by using a Kruskal–Wallis test and Mann–Whitney U -test. Statistical significance was declared at a p-value < 0.05. Results Among 296 participants, the majority of them had a poor level of knowledge (69.9%), practice (95.9%), and moderate attitude (62.5%) towards pharmacovigilance and ADRs reporting. The median (interquartile range) score of the students’ knowledge (maximum score = 15), attitude (maximum score = 50), and practice (maximum score = 5) towards PV and ADR reporting was 6 (5–8), 32 (28.25–35), and 1 (0–1), respectively. The KAP of the students has shown differences with age, sex, hearing of the term PV, and discipline. A lack of training on ADRs (49%) reporting and not knowing where and how to report ADRs (47.3%) were among the main reasons of MPN students for not reporting ADRs. Conclusion A majority of final-year MPN students had poor knowledge, practice, and a moderate attitude towards PV and ADRs reporting. The school of medicine, pharmacy, and nursing should adequately cover the issue of PV and ADRs reporting in the undergraduate curriculum.

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Medication‐related problems and adverse drug reactions in Ethiopia: A systematic review

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Cited by 18 publications

References 46 publications

The use of medicinal plants by pregnant women in Africa: A systematic review

The use of medicinal plants by pregnant women in Africa: A systematic review

Assessment of Adverse Drug Events, Their Risk Factors, and Management Among Patients Treated for Multidrug-Resistant TB: A Prospective Cohort Study From Pakistan

Knowledge, Attitude, and Practice of Medical, Pharmacy, and Nursing Students Towards Pharmacovigilance and Adverse Drug Reaction Reporting at University of Gondar College of Medicine and Health Sciences, Northwest Ethiopia: A Cross-Sectional Study

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