Medication-Related Osteonecrosis of the Jaw: 14 Years’ Retrospective Study on Pathogenetic Trigger Events

Abstract

Although events such as tooth extraction and oral surgery were considered for a while the sole triggering factor for Medication-Related Osteonecrosis of the Jaw (MRONJ), it is still unclear if trigger events may be precipitating factors that accelerate the onset of the disease that would have possibly occurred anyway. Therefore, this research aimed to retrospectively analyze MRONJ cases diagnosed in our tertiary referral hospital during the last 14 years, focusing on the onset of the disease, potential trigger events, and countermeasures to update the knowledge on their From the

Delayed Presentation of Mandibular Osteonecrosis Following Herpes Zoster Infection - A Case Report

“…[ 1 ] It directly harms bone cells and soft tissue from high-potency bisphosphonates or other cytotoxic drugs such as methotrexate, etanercept, adalimumab and rituximab. [ 1 2 ] Other conditions which precipitate this condition include myeloma, malignancies of other organs such as the breast and prostate, ischaemia of bone, disease-causing low bone turnover, persistent bony infection and osteoporosis. [ 1 2 ] A significant correlation has been found between trigger events and medication-related osteonecrosis of the jaw (MRONJ) in osteoporotic patients in recent studies, concluding the role of the trigger factor.…”

“…[ 1 2 ] Other conditions which precipitate this condition include myeloma, malignancies of other organs such as the breast and prostate, ischaemia of bone, disease-causing low bone turnover, persistent bony infection and osteoporosis. [ 1 2 ] A significant correlation has been found between trigger events and medication-related osteonecrosis of the jaw (MRONJ) in osteoporotic patients in recent studies, concluding the role of the trigger factor. [ 2 ] Documented presentations of osteonecrosis after herpes zoster (HZ) infection (HZI) are rare.…”

“…[ 1 2 ] A significant correlation has been found between trigger events and medication-related osteonecrosis of the jaw (MRONJ) in osteoporotic patients in recent studies, concluding the role of the trigger factor. [ 2 ] Documented presentations of osteonecrosis after herpes zoster (HZ) infection (HZI) are rare. [ 3 4 ] Unilateral involvement of jaw bone with spontaneous exfoliation of teeth is typical of the condition.…”