Medication-related factors associated with proton pump inhibitor prescription beyond official guidelines in older adults

Puchon, Erik; Goboova, Maria; Vano, Ivan; Fazekáš, Tomáš; Javorova-Rihova, Zuzana; Kuželová, M

doi:10.1007/s41999-020-00380-5

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2023

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“…9 In another study conducted in Slovakia, GERD (25%) was the most preferred indication for prescribing PPIs at hospitalization, which was found to be consistent with the results of our study. 17 According to a study conducted on outpatients in Indonesia, 79% of the indications of PPI therapy used were found to comply with the guidelines. A potential PPIs interaction risk with other drugs was found in 324 prescriptions (81%) out of 475 (Drug interactions were traced using Micromedex Solutions (IBM Micromedex Solutions.…”

Section: Figure 1bmentioning

confidence: 99%

Evaluation of Potential Drug Interactions with Proton Pump Inhibitors: A Retrospective Study

BAYUK¹,

DEDE²,

TEZCAN³

2023

J Lit Pharm Sci

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Proton pump inhibitors (PPIs) are weak base drugs with lipophilic structures and can pass through the parietal cell membrane. Since PPIs target the extracytoplasmic luminal area of the proton pump, it must reach the acidic space inside the parietal cell.For this reason, PPIs are administered in the form of a prodrug which is activated in an acidic environment. PPIs are protonated in the acidic environment and bind covalently to the H+/K+-ATPase enzyme, irreversibly inhibiting the acid secretion of the pro-

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confidence: 99%