Medication regimen complexity and its association with adherence and blood pressure control among hypertensive patients at selected hospitals of South Gondar Zone: A hospital based cross sectional study

Abstract

Introduction Despite the availability of effective antihypertensive medications, blood pressure (BP) control is suboptimal. High medication regimen complexity index (MRCI) is known to reduce adherence and may be the reason for poor BP control. However, there is no data in the present study areas. Hence, the aim of this study was to assess MRCI and its association with adherence and BP control among hypertensive patients at selected hospitals of South Gondar Zone. Methods A hospital based cross sectional study was conducted from December 1, 2020 to February 30, 2021 at selected hospitals of South Gondar Zone. Medication regimen complexity and adherence was evaluated using 65-item validated tool called MRCI and eight items Morisky Medication Adherence, respectively. Multivariable logistic regression analysis was done to determine the association between predictive and outcome variables. Results About 3.3% of participants were classified as having high HTN specific MRCI whereas 34.75% of participants were classified as having high patient level MRCI. Among participants, 37.8% were adherent to their medications, and 52.2% of respondents were categorized as having controlled BP. Multivariate logistic regression showed being married, and having lower education level was more likely and less likely to be adherent, respectively. Being illiterate, and having low HTN MRCI were more likely to have controlled BP in adjusted analyses. On the contrary, being non-adherent, not having health insurance, and having lower monthly income were less likely to have controlled BP. Conclusion A considerable proportion of patients had high MRCI. Having low HTN MRCI was more likely to have controlled BP. Simplification of a complex medication regimen for patients with HTN should be sought by physicians and pharmacists to improve BP control.

Retraction: Medication regimen complexity and its association with adherence and blood pressure control among hypertensive patients at selected hospitals of South Gondar Zone: A hospital based cross sectional study

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The PLOS ONE Editors After this article [1] was published, it came to light that the authors did not have permission to use the MMAS 1 -8 scale [2].In addition, PLOS identified concerns about the article's [1] study design and reporting. The MMAS 1 -8 scale was adapted and translated for this study, but the methods used for the adaptation and translation were not clearly reported.

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“…The PLOS ONE Editors After this article [1] was published, it came to light that the authors did not have permission to use the MMAS 1 -8 scale [2].…”

“…1 -8 scale (used in this study) was originally published in 2008[2], but the copyright for the scale was registered by Donald E. Morisky on September 21, 2018 (U.S. Copyright Registration No.…”