Medication Overuse Headache: an Updated Review and Clinical Recommendations on Management

Hird, Megan A.; Sandoe, Claire H

doi:10.1007/s11910-023-01278-y

Cited by 2 publications

(1 citation statement)

References 57 publications

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“…Prolonged or frequent use of these agents, particularly the combination containing caffeine, may promote MOH. 1 , 20 Beyond the risk of MOH, there are other concerns regarding the long-term safety and tolerability of these analgesics. For example, while short-term treatment with NSAIDs such as ibuprofen and naproxen is generally well tolerated, prolonged use of such agents has been associated with gastrointestinal bleeding, cardiovascular events, and renal failure.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Use of Rimegepant 75 mg for the Acute Treatment of Migraine is Associated with a Reduction in the Utilization of Select Analgesics and Antiemetics

Fullerton,

Pixton

2024

JPR

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Purpose To examine use of concomitant analgesics and antiemetics during treatment with rimegepant in adults with migraine. Patients and Methods This was a post hoc analysis of a long-term, open-label, safety study in adults with a history of 2–14 moderate or severe migraine attacks per month. Participants self-administered rimegepant 75 mg (1) up to once daily as needed (PRN) for 52 weeks or (2) every other day plus PRN (EOD+PRN) for 12 weeks. The PRN cohort was further divided based on baseline attack frequency, with PRN (2–8) and PRN (9–14) cohorts having a history of 2–8 or 9–14 attacks per month, respectively. Use of select analgesics and antiemetics was analyzed during a 30-day pre-treatment observation period (OP) and during rimegepant treatment. Results Overall, 1800 rimegepant-treated participants (PRN n = 1514, EOD+PRN n = 286) were included in the analysis. Select analgesics or antiemetics were used by 80.1% of participants during the OP. Among 1441 participants using analgesics or antiemetics during the OP, the proportion who did not use any analgesics or antiemetics following initiation of rimegepant treatment increased during weeks 1–4 (36.9%), 5–8 (52.6%), and 9–12 (56.5%). The mean number of days per month using analgesics or antiemetics was also significantly reduced over time in all cohorts beginning at weeks 1–4 ( P < 0.001 vs OP). This pattern of reduced analgesic or antiemetic use was consistent for all rimegepant cohorts, but was most pronounced in the EOD+PRN cohort in which 74.8% of participants reported ≥50% reduction in analgesic/antiemetic days at weeks 9–12. Reduction in use was maintained over time, with 61.3% of participants not using any analgesics or antiemetics during weeks 49–52 of PRN treatment. Conclusion Long-term treatment with oral rimegepant was associated with reduced analgesic and antiemetic use. Clinicaltrials.gov: NCT03266588.

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Section: Discussionmentioning

confidence: 99%