Medication Nonadherence: Implications for patient health outcomes in pharmacy practice

Al-Temimi, Ahmed Alaa; Krishnan, S.; Sandhu, Anisha Kaur; Bangash, Nida Sajid Ali

doi:10.22146/ijp.2236

Cited by 3 publications

(3 citation statements)

References 52 publications

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“…Those could influence neuropathy through improvement in controlling blood sugar and insulin sensitivity (Zilliox & Russell, 2019). Indeed, the medication factor is an important and critical point that affects disease progression (Al-Temimi et al, 2021). Adherence to medication consumption might involve a confounding factor (da Silva et al, 2019).…”

Section: Volume 35 Issue 1 (2024)mentioning

confidence: 99%

The Influence of MTHFR C677T Variants on Neuropathy Risk Among T2dm Patients Receiving Monotherapy Metformin

Yanuar,

Istyastono,

Virginia

2024

Indonesian J Pharm

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Neuropathy is the most common microvascular complication among type 2 diabetes mellitus (T2DM). Metformin consumption increases neuropathy risk. The Methylenetetrahydrofolate reductase (MTHFR) enzyme has confirmed its role in neuropathy. Metformin and MTHFR could decrease folate and induce hyperhomoscysteine. One of the common variants of the MTHFR gene is C677T and its located in the exon area. This study aimed to observe the association between variant C677T in the MTHFR gene and the risk of neuropathy among newly diagnosed T2DM patients with naive metformin. This cross-sectional study recruited 103 patients. The neuropathy risk was examined according to medical judgment through Neuropathy Symptom Score (NSS) and Neuropathy Disability Score (NDS) criteria. Genotyping C677T was performed using PCR-RFLP. This study found only one patient has a homozygote mutant, but more than 50% of patients were detected with allele mutants. There were no statistical differences in patient characteristics between CC and CT genotypes (p>0.05). Association between C677T and neuropathy risk was not significant statistically, either in the genotype model (p=0.97), allele model (p=0.82), and dominant model (p=0.91). There was still no significant association after adjusting for several confounding factors. We conclude that C677T in our population did not influence neuropathy risk. More specific criteria and laboratory parameters indicated neuropathy should be examined in the future study. Keywords: MTHFR, neuropathy, metformin, and T2DM

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Section: Volume 35 Issue 1 (2024)mentioning

confidence: 99%

The Influence of MTHFR C677T Variants on Neuropathy Risk Among T2dm Patients Receiving Monotherapy Metformin

Yanuar,

Istyastono,

Virginia

2024

Indonesian J Pharm

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“…Medication safety in the advancement stage is progressively impacted by the restrictions imposed by sponsors on the research policy, the lab program and the open sharing of data as the exploration schedule is negotiated with clinical associates [33]. There is developing public worries that nearby coordinated effort among academia and pharmaceutical manufacturers may antagonistically influence clinical practice and clinical studies [25,34,35].…”

Section: Promotional Activitiesmentioning

confidence: 99%

Scope of Pharmacovigilance: Comprehensive Review

Abbood¹,

Khalaf²,

Abudlqader³

et al. 2022

CSIJ

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Pharmacovigilance aims to preserve general health by identifying, evaluating, and minimizing health issues to ensure that the benefits of accessible treatments outweigh the potential risks. However, the retraction (withdrawal) of specific medications from global markets has increasingly focused on pharmacovigilance approaches, raised concerns about improvements to the current pharmacovigilance system, and highlighted the need to ensure uniformity among international guidelines governing the detailing of side effects ("Adverse Drug Reactions" - A.D.R.s). Concerns with the nature and safety of drugs as noted by medication guidelines. A sound medication policy is required to ensure the safety, viability, and nature of pharmaceuticals as well as the accuracy and applicability of the medication information made available to the general public. Medication guidelines cover a wide range of functions, including authorizing, reviewing manufacturing facilities and distribution channels, item evaluation and enrollment, observing adverse drug reactions (ADR), controlling medication advancement and publicizing, and controlling clinical medication preliminary studies.

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“…Aside from being a significant contributor to ache, it is additionally connected with diminishing physical movement and may prompt restriction of one's freedom and influence wellbeing related nature of life and furthermore prompts loss of productivity [5][6]. Ladies matured 50 years or more than knee OA can be considered among the interminable noncommunicable illnesses, and inquiries through the lifestyle and propensities (for example, from sociological points of view) can be extremely useful in distinguishing more hazard factors that are manageable for anticipation and control of this perilous issue [7][8][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Development of Knee Osteoarthritis in Older Age Women Patients

2023

JPTCP

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Background: Knee osteoarthritis is a joint disorder that shows up essentially in elderly persons and is characterized by disintegration in the articular ligament, osteophyte, synovitis inflammation, and subchondral bone firmness. Knee osteoarthritis has numerous reasons, like age, presently solidly settled as a general medical issue. It is the most impairing illness in multiple nations. Knee osteoarthritis is viewed as the more typical type of ailment in a grown-up. Old ladies are seen as increasingly influenced by this ailment. From the accessible confirmations, it is currently sensible to consider this illness as one of the most significant among the interminable non-transferable maladies and examination for the hazard factors related to this issue is substantial. Aims: To describe the risk factors for developing symptomatic knee osteoarthritis in female Iraqi patients. Patients and Methods: This investigation incorporates 50 female patients with clinical and radiological highlights of knee osteoarthritis in different age groups. Result: The evaluated pervasiveness of knee osteoarthritis among women matured 40-49 years or more is 14 % of who had knee osteoarthritis with injury or trauma and 86% of women who had knee Osteoarthritis without injury or trauma. We additionally found that 94% of the ladies who experienced difficulty in doing daily schedule actions had a high increment in the levels of ESR, PLT, and CRP in serum. Conclusion: The elevation of knee osteoarthritis prevalence in female patients is because of the fact that most female patients develop knee osteoarthritis with aging. So that the quality of life of female patients in society will decline due to multiple factors affecting those women, with some high serum levels indicators.

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Medication Nonadherence: Implications for patient health outcomes in pharmacy practice

Cited by 3 publications

References 52 publications

The Influence of MTHFR C677T Variants on Neuropathy Risk Among T2dm Patients Receiving Monotherapy Metformin

The Influence of MTHFR C677T Variants on Neuropathy Risk Among T2dm Patients Receiving Monotherapy Metformin

Scope of Pharmacovigilance: Comprehensive Review

Development of Knee Osteoarthritis in Older Age Women Patients

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