Medication-Induced Hypomania in — Asperger's Disorder

Damore, Joseph F.; Stine, John J.; Brody, Lynne

doi:10.1097/00004583-199803000-00006

Cited by 41 publications

(10 citation statements)

References 1 publication

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“…On the one hand, double-blind, placebo-controlled studies in children and adolescents with primary anxiety disorders demonstrate safe, effective treatment with numerous serotonergic agents, including, but not limited to, fluoxetine, fluvoxamine, or sertraline (The Research Unit on Pediatric Psychopharmacology Anxiety Study Group 2001; Birmaher et al 2003;Fairbanks et al 1997;Riddle et al 2001;Rynn et al 2001). On the other hand, numerous case reports document the risk of mania induced by such serotonergic agents in children without BPD (Damore et al 1998;Ghaziuddin 1994;Go et al 1998). Moreover, the Food and Drug Administation (FDA) in the United States and the Medicines and Healthcare Products Regulatory Agency (MHRA) in the United Kingdom have both investigated the safety of antidepressants in children, focusing especially on selective serotonin reuptake inhibitors (SSRIs).…”

Section: Discussionmentioning

confidence: 99%

Comorbid Anxiety in Phenotypes of Pediatric Bipolar Disorder

Dickstein

Rich

Binstock

et al. 2005

Journal of Child and Adolescent Psychopharmacology

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Section: Discussionmentioning

confidence: 99%

Comorbid Anxiety in Phenotypes of Pediatric Bipolar Disorder

Dickstein

Rich

Binstock

et al. 2005

Journal of Child and Adolescent Psychopharmacology

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“…Valproate has also been reported to improve behavioral and core ASD symptoms in a case series (Level 4) of ASD children with and without epilepsy (26) and to substantially improve ASD symptoms in case reports and series (Level 4) of children with subclinical epileptic-like discharges on EEG (27–32). In a case series (Level 4) of children with ASD or ASD-like symptoms and epilepsy, Gilbert reported that 41% treated with valproate demonstrated positive psychotropic effects (16).…”

Section: Traditional Treatmentsmentioning

confidence: 99%

A review of traditional and novel treatments for seizures in autism spectrum disorder: findings from a systematic review and expert panel

Frye

Rossignol²,

Casanova

et al. 2013

Front. Public Health

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Despite the fact that seizures are commonly associated with autism spectrum disorder (ASD), the effectiveness of treatments for seizures has not been well studied in individuals with ASD. This manuscript reviews both traditional and novel treatments for seizures associated with ASD. Studies were selected by systematically searching major electronic databases and by a panel of experts that treat ASD individuals. Only a few anti-epileptic drugs (AEDs) have undergone carefully controlled trials in ASD, but these trials examined outcomes other than seizures. Several lines of evidence point to valproate, lamotrigine, and levetiracetam as the most effective and tolerable AEDs for individuals with ASD. Limited evidence supports the use of traditional non-AED treatments, such as the ketogenic and modified Atkins diet, multiple subpial transections, immunomodulation, and neurofeedback treatments. Although specific treatments may be more appropriate for specific genetic and metabolic syndromes associated with ASD and seizures, there are few studies which have documented the effectiveness of treatments for seizures for specific syndromes. Limited evidence supports l-carnitine, multivitamins, and N-acetyl-l-cysteine in mitochondrial disease and dysfunction, folinic acid in cerebral folate abnormalities and early treatment with vigabatrin in tuberous sclerosis complex. Finally, there is limited evidence for a number of novel treatments, particularly magnesium with pyridoxine, omega-3 fatty acids, the gluten-free casein-free diet, and low-frequency repetitive transcranial magnetic simulation. Zinc and l-carnosine are potential novel treatments supported by basic research but not clinical studies. This review demonstrates the wide variety of treatments used to treat seizures in individuals with ASD as well as the striking lack of clinical trials performed to support the use of these treatments. Additional studies concerning these treatments for controlling seizures in individuals with ASD are warranted.

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“…While none of these has shown conclusively the etiology of OCD and ASD, they provide evidence that biomedical systems are similar and that effective treatments for OCD should be examined in children who are dually diagnosed. Two reports of psychopharmacological treatment for OCD symptoms in children with Autism Spectrum Disorders have produced positive results (Damore et al 1998;Storch 1999). Only one report of CBT in a child with Autism has been published (Reaven and Hepburn 2003).…”

Section: Introductionmentioning

confidence: 99%

Brief Report: Exposure and Response Prevention for Obsessive Compulsive Disorder in a 12-year-old with Autism

Lehmkuhl

Storch

Geffken

2007

J Autism Dev Disord

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Obsessive Compulsive Disorder (OCD) involves exaggerated or excessive worry about threatening and non-threatening stimuli coupled with impairing rituals believed to reduce anxiety. Autism Spectrum Disorders (ASD) are characterized by impairment in social and communicative activities as well as restricted and repetitive behaviors. Approximately 2% of children with ASD are also diagnosed with OCD. Although there is extensive research demonstrating the effectiveness of behavioral interventions for pediatric OCD, little is known about how effective these treatments are for children who have a dual diagnosis of OCD and ASD. This report describes a 12-year-old male with Autism who was treated successfully with cognitive behavioral therapy with exposure and response prevention. This case study provides initial support that cognitive-behavioral therapy is effective in symptom reduction for children with comorbid autism and OCD.

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Medication-Induced Hypomania in — Asperger's Disorder

Cited by 41 publications

References 1 publication

Comorbid Anxiety in Phenotypes of Pediatric Bipolar Disorder

Comorbid Anxiety in Phenotypes of Pediatric Bipolar Disorder

A review of traditional and novel treatments for seizures in autism spectrum disorder: findings from a systematic review and expert panel

Brief Report: Exposure and Response Prevention for Obsessive Compulsive Disorder in a 12-year-old with Autism

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