Medication Detection by a Combinatorial Fluorescent Molecular Sensor

Rout, Bhimsen; Unger, Linor; Armony, Gad; Iron, Mark A.; Margulies, David H.

doi:10.1002/ange.201206374

Cited by 26 publications

(16 citation statements)

References 96 publications

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“…In a new adaptation of the multicomponent sensing technique, Rout et al [64] developed receptor 10 ( Fig. 10), a probe containing multiple Wulff-type boronic acids appended to a proline amino acid with four different fluorophores attached.…”

Section: Multicomponent Sensing Of Saccharide-containing Medicationsmentioning

confidence: 99%

Molecular recognition with boronic acids—applications in chemical biology

2013

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Small molecules have long been used for the selective recognition of a wide range of analytes. The ability of these chemical receptors to recognise and bind to specific targets mimics certain biological processes (such as proteinsubstrate interactions) and has therefore attracted recent interest. Due to the abundance of biological molecules possessing polyhydroxy motifs, boronic acids-which form fivemembered boronate esters with diols-have become increasingly popular in the synthesis of small chemical receptors. Their targets include biological materials and natural products including phosphatidylinositol bisphosphate, saccharides and polysaccharides, nucleic acids, metal ions and the neurotransmitter dopamine. This review will focus on the many ways in which small chemical receptors based on boronic acids have been used as biochemical tools for various purposes, including sensing and detection of analytes, interference in signalling pathways, enzyme inhibition and cell delivery systems. The most recent developments in each area will be highlighted.

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Section: Multicomponent Sensing Of Saccharide-containing Medicationsmentioning

confidence: 99%

Molecular recognition with boronic acids—applications in chemical biology

2013

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“…F luorescent labelling is a powerful tool for high-sensitivity detection of biomolecular interactions [1][2][3][4][5] . In particular, fluorescence is one of the most frequently used means of evaluating ligand-analyte complex formation in homogeneous and heterogeneous assays, as transduction of the target-binding event facilitated by fluorophores enables real-time monitoring 6 .…”

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An angular fluidic channel for prism-free surface-plasmon-assisted fluorescence capturing

et al. 2013

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Surface plasmon excitation provides stronger enhancement of the fluorescence intensity and better sensitivity than other sensing approaches but requires optimal positioning of a prism to ensure optimum output of the incident light. Here we describe a simple, highly sensitive optical sensing system combining surface plasmon excitation and fluorescence to address this limitation. V-shaped fluidic channels are employed to mimic the functions of a prism, sensing plate, and flow channel in a single setup. Superior performance is demonstrated for different biomolecular recognition reactions on a self-assembled monolayer, and the sensitivity reaches 100 fM for biotin-streptavidin interactions. Using an antibody as a probe, we demonstrate the detection of intact influenza viruses at 0.2 HA units ml À 1 levels. The convenient sensing system developed here has the advantages of being prism-free and requiring less sample (1-2 ml), making this platform suitable for use in situations requiring low sample volumes.

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confidence: 99%

“…This sensor is the second member of the combinatorial fluorescent molecular sensor family, developed by our group42, which mimics the function of the olfactory system by integrating several nonspecific signalling receptors on a single molecular platform43. Unlike its predecessor414243, however, or any other fluorescent probe that responds to several analytes2444 or an analyte group43, m-SMS was designed to operate as a universal sensor that can discriminate among a vast number of distinct chemical species. We show that this property not only distinguishes m-SMS from other types of fluorescent molecular sensors, but also from other chemical security systems45678910111213141516171819202122272829303132333435363738394041 by enabling it to function as a molecular cipher device that can convert distinct chemical structures into unique encryption keys.…”

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confidence: 99%

Message in a molecule

et al. 2016

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Since ancient times, steganography, the art of concealing information, has largely relied on secret inks as a tool for hiding messages. However, as the methods for detecting these inks improved, the use of simple and accessible chemicals as a means to secure communication was practically abolished. Here, we describe a method that enables one to conceal multiple different messages within the emission spectra of a unimolecular fluorescent sensor. Similar to secret inks, this molecular-scale messaging sensor (m-SMS) can be hidden on regular paper and the messages can be encoded or decoded within seconds using common chemicals, including commercial ingredients that can be obtained in grocery stores or pharmacies. Unlike with invisible inks, however, uncovering these messages by an unauthorized user is almost impossible because they are protected by three different defence mechanisms: steganography, cryptography and by entering a password, which are used to hide, encrypt or prevent access to the information, respectively.

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Medication Detection by a Combinatorial Fluorescent Molecular Sensor

Cited by 26 publications

References 96 publications

Molecular recognition with boronic acids—applications in chemical biology

Molecular recognition with boronic acids—applications in chemical biology

An angular fluidic channel for prism-free surface-plasmon-assisted fluorescence capturing

Message in a molecule

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