Medication adherence framework: A population‐based pharmacokinetic approach and its application in antimalarial treatment assessments
Junjie Ding,
Richard M. Hoglund,
Joel Tarning
Abstract:We reported here on the development of a pharmacometric framework to assess patient adherence, by using two population‐based approaches – the percentile and the Bayesian method. Three different dosing strategies were investigated in patients prescribed a total of three doses; (1) non‐observed therapy, (2) directly observed administration of the first dose, and (3) directly observed administration of the first two doses. The percentile approach used population‐based simulations to derive optimal concentration p… Show more
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