Medication adherence and quality of life among Nigerian outpatients with schizophrenia

Adelufosi, Adegoke Oloruntoba; Adebowale, Timothy Olaolu; Abayomi, Olukayode; Mosanya, Julianah Temilola

doi:10.1016/j.genhosppsych.2011.09.001

Cited by 53 publications

(60 citation statements)

References 23 publications

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“…Regarding the drug regimen, study participants who were on poly therapy were about two times more likely to be nonadherent than those on mono therapy which is in line with study done in Nigeria in which participants who took significantly fewer number of medications were independently and negatively associated with antipsychotic drug non adherence [8].…”

Section: Discussionsupporting

confidence: 84%

“…The overall prevalence of antipsychotic drug non adherence in the current study area was found to be slightly higher than study done in Nigeria and India which were 40.3% [8] and 35.5% [17] respectively. Meta-analysis of published literature indicated that the prevalence of antipsychotic drug non adherence in schizophrenia ranged from 40% to 50% [18].…”

Section: Discussioncontrasting

confidence: 77%

“…Similar studies were done in different part of Africa to determine magnitude of antipsychotic drug non adherence on schizophrenia patients. Study done in Nigeria on 313 schizophrenia patients to examine medication adherence among outpatients in relation to their subjective quality of life and other socio demographic, clinical and service related factors indicated that 40.3% of the respondents were medication non adherent [8]. Related study done on 217 schizophrenia patients to assess factors associated with relapse in Johannesburg; South Africa indicates that more than one third of patients (35.8%) were non adherent to their treatment [9].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prevalence of Antipsychotic Drug Non Adherence and Associated Factors Among Patients with Schizophrenia Attending at Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia: Institutional Based Cross Sectional Study

Girma¹,

Abdisa²,

Fikadu³

2017

Health Sci J

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Background: Drug non adherence is a problem in all areas of medicine, and psychiatry is no exception. Mental health institutions are widely over burdened by mental ill patient who sought frequent treatment as a result of drug non adherence. Although patients suffering from psychiatric disorders are the most likely not to adhere to treatment than any other physical illness; there was no study done to determine the prevalence and associated factors of antipsychotic drug non adherence among schizophrenia patients in Ethiopia. So this study was aimed to assess the prevalence and associated factors of antipsychotic drug non-adherence among patients with schizophrenia attending at Amanuel mental specialized hospital.

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Section: Discussionsupporting

confidence: 84%

Section: Discussioncontrasting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence of Antipsychotic Drug Non Adherence and Associated Factors Among Patients with Schizophrenia Attending at Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia: Institutional Based Cross Sectional Study

Girma¹,

Abdisa²,

Fikadu³

2017

Health Sci J

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“…26 Adelufosi and colleagues identified medication nonadherence as the illness-related factor that significantly correlated with lower scores in all the domains of the WHOQOL-Bref. 29 While, Olusina and Ohaeri in their study published in 2003 reported no statistically significant associations between sociodemographic and illness related factors and QOL. 30 Studies conducted outside Nigeria have reported varied associations between QOL and different sociodemographic factors in psychiatric patients.…”

Section: Discussionmentioning

confidence: 92%

“…Of the 6 studies that were eligible for this review, 4 investigated QOL among patients who were receiving treatment on an out-patient basis [26][27][28][29] , while 2 were conducted among patients who were recently discharged from in-patient care. 25,30 Although, none of the studies we reviewed actually performed a repeat or prospective QOL evaluation, previous studies have shown varied results concerning QOL evaluation in the context of the period that the patients were recruited.…”

Section: Discussionmentioning

confidence: 99%

A review of quality of life studies in Nigerian patients with psychiatric disorders

Aloba¹,

Fatoye²,

Mapayi³

et al. 2013

Afr. J. Psych

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The concept of Quality of Life is becoming an increasingly important measure of the impact of psychiatric disorders and is now recognized as useful in the healthcare evaluation of patients with psychiatric disorders. The aim of this review was to document and analyze the research data on quality of life in Nigerian patients with psychiatric disorders. The electronic databases, Medline and Pubmed were searched for published articles on quality of life in Nigerian patients with psychiatric disorders. A total of 6 studies met the inclusion criteria. All the studies employed the generic World Health Organization Quality of Life Scale -Brief version, which is the only quality of life instrument whose psychometric properties have been evaluated among Nigerian patients with psychiatric disorders. Some of the studies revealed that quality of life was significantly associated with socio demographic factors such marital and employment status and social support. Poor quality of life was reported to be associated with illnessrelated factors such as co morbid medical problems, presence of anxiety and depressive symptoms and non adherence to medications. All the studies with the exception of two were conducted in centers located in South-western Nigeria. Quality of life in Nigerian patients suffering from psychiatric disorders is under-researched. There is need for more studies to prospectively investigate quality of life and associated factors among Nigerian patients with psychiatric disorders.

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Non-adherence to medication in patients with psychotic disorders: epidemiology, contributing factors and management strategies

2013

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Although non-adherence is common across all branches of medicine, psychotic disorders pose additional challenges that increase its risk. Despite the importance of non-adherence, clinicians generally spend too little time on assessing and addressing adherence attitudes and behaviors. Importantly, how adherence is measured significantly impacts the findings, and the most frequently employed methods of asking patients or judging adherence indirectly based on efficacy or tolerability information have poor validity. Novel technologies are being developed that directly assess adherence and that can also be used to both provide real-time feedback to clinicians and serve as an intervention with patients. Several treatments are available that can positively impact adherence. Among psychosocial interventions, those combining multiple approaches and involving multiple domains seem to be most effective. Although long-acting injectable antipsychotics are theoretically a very powerful tool to assure adherence and signal non-adherence, recent results from randomized controlled trials failed to show superiority compared to oral antipsychotics. These data are in contrast to nationwide cohort studies and mirror-image studies, which arguably include more representative patients receiving long-acting antipsychotics in clinical practice. This disconnect suggests that traditional randomized controlled trials are not necessarily the best way to study interventions that are thought to work via reducing non-adherence. Clearly, non-adherence is likely to remain a major public health problem despite treatment advances. However, increasing knowledge about factors affecting adherence and leveraging novel technologies can enhance its early assessment and adequate management, particularly in patients with psychotic disorders.

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Medication adherence and quality of life among Nigerian outpatients with schizophrenia

Cited by 53 publications

References 23 publications

Prevalence of Antipsychotic Drug Non Adherence and Associated Factors Among Patients with Schizophrenia Attending at Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia: Institutional Based Cross Sectional Study

Prevalence of Antipsychotic Drug Non Adherence and Associated Factors Among Patients with Schizophrenia Attending at Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia: Institutional Based Cross Sectional Study

A review of quality of life studies in Nigerian patients with psychiatric disorders

Non-adherence to medication in patients with psychotic disorders: epidemiology, contributing factors and management strategies

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