Medicated Straws Based on Electrospun Solid Dispersions

Farkas, Balázs; Balogh, Attila; Farkas, Attila; Domokos, András; Borbás, Enikő; Marosi, György

doi:10.3311/ppch.11931

Cited by 9 publications

(6 citation statements)

References 31 publications

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“…Electrospinning (ES) has gained great attention due to the ability to form large surface area fibrous ASDs from polymeric solutions and melts under the drawing force of the electrostatic field (Balogh et al, 2018, Balogh et al, 2014, Zupančič et al, 2018b. Direct current electrospinning (DCES) is the simplest and most common method for preparing electrospun ASDs with controlled drug release (e.g., sustained (Angkawinitwong et al, 2017, Liu et al, 2018, targeted (Nagy et al, 2013) or ultrafast release (Farkas et al, 2018). Despite these advantages the productivity of DCES is quite low (∼1-2 g/h) for industrial applications (Lukáš et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Corona alternating current electrospinning: A combined approach for increasing the productivity of electrospinning

Farkas

Balogh

Cselko

et al. 2019

International Journal of Pharmaceutics

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Corona alternating current electrospinning (C-ACES), a scaled-up productivity electrospinning method was developed by combining the intense forces of the alternating electrostatic field and a sharp-edged spinneret design with increased free surface. C-ACES reached two orders of magnitude higher productivity (up to 1200 mL/h) than the classical single needle direct current electrospinning (DCES) without any alteration of fiber properties.

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Section: Introductionmentioning

confidence: 99%

Corona alternating current electrospinning: A combined approach for increasing the productivity of electrospinning

Farkas

Balogh

Cselko

et al. 2019

International Journal of Pharmaceutics

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“…Completely homogeneous distribution of drugs in polymer matrix was achieved this way according to Raman chemical mapping [52]. Ultrafast drug release of cardiovascular drug (carvedilol) was achieved from the prepared fibrous formulations (inserted into straws) suggesting that such a drug delivery system is suitable for storing the formulation in a stable solid dosage form and turning it rapidly into liquid form before administration [53]. The next steps towards realization of realtime release (i.e.…”

Section: Technologies Of Innovative Pharmaceuticalsmentioning

confidence: 99%

Pharmaceutical and Macromolecular Technologies in the Spirit of Industry 4.0

Marosi

Hirsch

Bocz

et al. 2018

Period. Polytech. Chem. Eng.

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Well designed (multilayer, adaptive, reactive) interphases, being a key element of multicomponent structures, could be tailored to different requirements through controlled technologies. This is the link connecting various green, safe, healthy materials and innovative pharmaceuticals. Upgraded recycling could be performed by interfacial consolidation of self-reinforced composites, the flame retardancy of which is feasible with surprisingly low amount of flame retardant. Examples are shown how the reinforced and foamed forms of thermosetting and thermoplastic biopolymers can play a significant role (after flame retardant modification) in the development of airplanes and electric cars. Biopolymer nanofibres, such as polycaprolactone and polyhydroxybutyrate, could be formed with increased productivity for various medical uses. Raman-based control of the units of integrated continuous technologies has been elaborated including controlled formation of crystals with polymer interlayer for direct tableting.

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“…Solubility and permeability are the two key parameters for the correlation of in vitro dissolution and in vivo bioavailability results of pure active pharmaceutical ingredients (APIs). In case of poorly water-soluble APIs, the solubility might be altered when using solubilizing agents or formulating amorphous solid dispersions [1][2][3]. Recent studies demonstrate that not only solubility, but also effective permeability (P eff ) of the API may change due to the addition of formulation additives [4], and also there is a certain mathematical relation between the two parameters [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Surfactants and pH Modifying Agents on the Dissolution and Permeation of Pimobendan

Tőzsér

Kovács²,

Kádár³

et al. 2023

Period. Polytech. Chem. Eng.

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Solubility and permeability are key parameters for establishing in vitro-in vivo correlation for poorly water-soluble active pharmaceutical ingredients (APIs). Recent studies demonstrate that not only solubility, but also effective permeability of the API may change due to the addition of solubilizing agents, and there is a certain mathematical relation between these physicochemical parameters. The aim of this study was to show the importance of early screening of solubility and permeability in presence of additives in order to achieve the expected bioavailability of the API. In this work, the effect of surfactants and microenvironmental pH modifiers were in focus, and pimobendan was chosen as model drug.In the case of pH modifiers, the equilibrium solubility of the API increased, while the permeability decreased significantly. No negative effect was observed for two surfactants at low additive levels, but these two additives also exhibited a slightly negative effect on permeability when used at higher concentrations. In the simultaneous dissolution-permeation studies the surfactants-containing formulation was found to have slightly higher flux than the pH-modifier-containing one. It can be due to the phenomenon that the dissolution of the active substance can be enhanced by these surfactants without any significant permeability reducing effect.The results obtained from the present study clearly demonstrate the importance of studying drug-additive interactions in every step of formulation development and based on these, the selection of the appropriate quality and quantity of additives. In addition, the results also underline the significance of performing simultaneous dissolution-permeation studies to predict bioavailability.

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Medicated Straws Based on Electrospun Solid Dispersions

Cited by 9 publications

References 31 publications

Corona alternating current electrospinning: A combined approach for increasing the productivity of electrospinning

Corona alternating current electrospinning: A combined approach for increasing the productivity of electrospinning

Pharmaceutical and Macromolecular Technologies in the Spirit of Industry 4.0

The Effect of Surfactants and pH Modifying Agents on the Dissolution and Permeation of Pimobendan

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