Medicated-related burden and adherence in patients with co-morbid type 2 diabetes mellitus and hypertension

Baah-Nyarkoh, Emmanuella; Alhassan, Yakubu; Dwomoh, Andrews K.; Kretchy, Irene A.

doi:10.1016/j.heliyon.2023.e15448

Cited by 9 publications

(7 citation statements)

References 34 publications

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“…The following therapy-related factors affected medication adherence: the number of medications, 17 , 24 , 29 , 30 , 36 , 37 medication-related burden, 16 , 27 medication therapy management, 38 frequency of medication change, 31 side effects, 29 , 35 drug combination 35 , therapy duration, 29 insulin therapy 36 and statins use. 24 …”

Section: Resultsmentioning

confidence: 99%

“…Health insurance, 30 , 36 lack of financial resources 13 , 46 , employment status 39 , 40 , societal norms, 17 social support, 29 , 32 , 47 monthly expenditure on medications, 16 Medication Costs 29 ,mode of payment for medical bills 35 , low income 39 ,economic resources to travel for consultation, 32 have support from their families or close acquaintances, 32 family support through reminders 44 were the socio-economic factors associated with medication adherence among individuals with comorbid hypertension and diabetes.…”

Section: Resultsmentioning

confidence: 99%

“… 100 17 Factors influencing long-term medication non-adherence among diabetes and hypertensive patients in Ghana: A qualitative investigation Ghana In-dept interviews N/A Interview(survey) Policy makers to act swiftly with appropriate interventions to encourage adherence among patients. 70 16 Medicated-related burden and adherence in patients with co-morbid type 2 diabetes mellitus and hypertension Ghana cross-sectional study Self-report MARS 5 36.80% N/A The interventions should also encourage fixed-dose drug combination to reduce medication-related burden while promoting better adherence and clinical outcomes. 87.5 25 Impact of pharmaceutical education on medication adherence and its clinical efficiency in patients with type 2 diabetes and systemic arterial hypertension Mexico Randomized control trial Self-report Morisky Medication Adherence Scale Intervention group (43.5%) and the control group (2.3%) Education and counselling by pharmacist This highlights the need for patient-centered medical care to include pharmacist-delivered educational and counselling strategies.…”

Section: Methodsmentioning

confidence: 99%

“…Nonadherence disrupts blood pressure and glucose regulation, reducing the therapeutic efficacy of medications and increasing the chance of side effects. 15 , 16 This exposes patient to increased symptom burden and diminished quality of life. 17 , 18 …”

Section: Introductionmentioning

confidence: 99%

“…Medication adherence is a pillar of effective illness treatment in the complex context of hypertension and diabetes co-morbidity. 16 , 21 The interaction between these diseases needs a rigorous and thorough treatment strategy, with the patient bearing responsibility for drug adherence. A scoping review concentrating on medication adherence in hypertension and diabetes co-morbidity serves as a key compass for navigating the intricacies of these intertwined illnesses.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Factors influencing medication adherence in co-morbid hypertension and diabetes patients: A scoping review

Kwakye,

Kretchy,

Peprah

et al. 2024

Exploratory Research in Clinical and Social Pharmacy

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Factors influencing medication adherence in co-morbid hypertension and diabetes patients: A scoping review

Kwakye,

Kretchy,

Peprah

et al. 2024

Exploratory Research in Clinical and Social Pharmacy

Self Cite

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Evaluation of viral suppression and medication-related burden among HIV-infected adults in a secondary care facility

Hedima,

Ohieku,

David

et al. 2024

Exploratory Research in Clinical and Social Pharmacy

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Treatment burden and regimen fatigue among patients with HIV and diabetes attending clinics of Tikur Anbessa specialized hospital

Muhammed,

Hassen,

Taye

et al. 2024

Sci Rep

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Nascent studies showed that patients with chronic medical illnesses such as diabetes mellitus (DM) and HIV/AIDS are highly vulnerable to face both treatment burden and regimen fatigue. However, an attempt made so far in this sphere in sub-Saharan African health care context is dearth. Thus, this study aimed to determine the level of treatment burden and regimen fatigue of diabetic and HIV patients attending adult diabetic and ART clinics of TASH and explore patients’ and health care workers’ propositions to reduce treatment burden and regimen fatigue. An explanatory sequential mixed methods study was conducted at the adult HIV and DM clinics of TASH, Addis Ababa, Ethiopia from February 01-March 30, 2022. Simple random and purposive sampling techniques were employed to select participants for quantitative and qualitative studies, respectively. Descriptive analysis was done to summarize the quantitative data. Logistic and linear regression analyses were performed to identify predictors of treatment burden and regimen fatigue, respectively. P value < 0.05 was considered statistically significant. Qualitative data was analyzed by using a thematic analysis. A total of 300 patients (200 diabetes and 100 HIV) were included in the quantitative study. For the qualitative study, 14 patients and 10 health care workers (six nurses and four medical doctors) were included. Participants' mean global Treatment Burden Questionnaire (TBQ) and Treatment Regimen Fatigue Scale (TRFS) score were 28.86 ± 22.13 and − 42.82 ± 17.45, respectively. Roughly, 12% of patients experienced a high treatment burden. The presence of two or more comorbidities (adjusted odds ratio [AOR] = 7.95, 95% confidence interval [CI] 1.59–39.08), daily ingestion of more than five types of prescribed medications (AOR = 6.81, 95%CI 1.59–29.14), and good knowledge about DM and/or HIV (AOR = 0.33, 95%CI 0.12–0.92) were predictors of treatment burden. Poor availability of medications (β = 0.951, p < 0.001) was the only predictor of regimen fatigue. Patients and health care workers primarily proposed to foster self-care efficacy, advance administrative services of the clinic and hospital, and improve healthcare system provision. The findings of this study unveiled that a considerable proportion of patients experienced low levels of treatment burden and regimen fatigue. This study showed that boosting the patients’ self-care efficacy, upgrading administrative services of the clinic and hospital, and promoting the healthcare system provision had enormous significance in reducing treatment burden and regimen fatigue. Therefore, when designing patient-specific healthcare interventions for both HIV and diabetic patients’ various factors affecting both treatment burden and regimen fatigue should be considered to achieve the desired goals of therapy.

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Medicated-related burden and adherence in patients with co-morbid type 2 diabetes mellitus and hypertension

Cited by 9 publications

References 34 publications

Factors influencing medication adherence in co-morbid hypertension and diabetes patients: A scoping review

Factors influencing medication adherence in co-morbid hypertension and diabetes patients: A scoping review

Evaluation of viral suppression and medication-related burden among HIV-infected adults in a secondary care facility

Treatment burden and regimen fatigue among patients with HIV and diabetes attending clinics of Tikur Anbessa specialized hospital

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