Medical versus surgical interventions for open angle glaucoma

Burr, Jennifer; Azuara‐Blanco, Augusto; Avenell, Alison

doi:10.1002/14651858.cd004399

Cited by 8 publications

(12 citation statements)

References 60 publications

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“…IOP is lowered as a consequence of aqueous humor (AH) leaving the eye through this channel, thereby forming a subconjunctival filtration depot or bleb. AH exits the bleb by multiple pathways including transconjunctival filtration and absorption through the episcleral veins (Burr et al, 2005;Hitchings, 1998).…”

mentioning

confidence: 99%

Modulation of wound healing in glaucoma surgery

Velde¹,

Bergen²,

Vandewalle³

et al. 2015

Progress in Brain Research

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mentioning

confidence: 99%

Modulation of wound healing in glaucoma surgery

Velde¹,

Bergen²,

Vandewalle³

et al. 2015

Progress in Brain Research

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“…The limitations of our study we have to point out are as follows: (1) there are numerous anatomic differences between rabbit and human eyes. Notably, eyeball motion is more frequent in humans, eyelid pressure is higher, and the iris is less prone to incarcerate the channel in rabbits than in man, so the potential for the mixture to ooze into the anterior chamber is higher in patients [19].…”

Section: Discussionmentioning

confidence: 99%

“…Glaucoma filtration surgery (GFS) is considered the most effective therapy to reduce intraocular pressure (IOP) and maintain vision [1,2]. However, excessive postoperative scarring at the bleb site remains the most frequent cause of the failure.…”

Section: Introductionmentioning

confidence: 99%

Effects of bevacizumab loaded PEG-PCL-PEG hydrogel intracameral application on intraocular pressure after glaucoma filtration surgery

Han

Wang

et al. 2015

J Mater Sci: Mater Med

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PEG-PCL-PEG (PECE) hydrogel for intracameral injection as a sustained delivery system can get a stable release of the medication and achieve an effective local concentration. The injectable PECE hydrogel is thermosensitive nano-material which is flowing sol at low temperature and can shift to nonflowing gel at body temperature. This study evaluated the intracameral injection of bevacizumab combined with a PECE hydrogel drug release system on postoperative scarring and bleb survival after experimental glaucoma filtration surgery. The best result was achieved in the bevacizumab loaded PECE hydrogels group, which presented the lowest IOP values after surgery. And the blebs were significantly more persistent in this group. Histology, Massion trichrome staining and immunohistochemistry further demonstrated that glaucoma filtration surgery in combination with bevacizumab loaded PECE hydrogel resulted in good bleb survival due to scar formation inhibition. In conclusions, this study demonstrated that bevacizumab-loaded PECE hydrogel for intracameral injection as a sustained delivery system provide a great opportunity to increase the therapeutic efficacy of glaucoma filtration surgery.

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“…Noch immer gilt die Trabekulektomie (TE) als der Goldstandard der chirurgischen Glaukomtherapie [3]. Bei der TE handelt es sich um einen filtrierenden Eingriff, der durch eine Art Ventil aus der Vorderkammer über ein sogenanntes Filterkissen einen besseren Abfluss des Kammerwassers unter die Bindehaut ermöglicht [4]. Um das Risiko einer Vernarbung des Filterkissens zu reduzieren, werden in der Regel intraoperativ Mitomycin C und postoperativ topische Steroide sowie 5-Fluorouracil-Injektionen eingesetzt.…”

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