Medical use of hyaluronic acid – A 2023 perspective

Wollina, Uwe

doi:10.25259/csdm_104_2023

Cited by 1 publication

(1 citation statement)

References 18 publications

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“…Hyaluronic acid (HA) plays an important role in a wide range of medical physiological and pathological conditions: Notably, it finds application in dermatology, ophthalmology, cosmetic medicine, and rheumatology [ 1 , 2 , 3 ]. Its significance extends to wound healing, granulation, and cell migration [ 4 ]. However, the efficacy of HA in rheumatology remains a subject of controversy at times [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic Acid in Rheumatology

Sprott,

Fleck

2023

Pharmaceutics

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Hyaluronic acid (HA), also known as hyaluronan, is an anionic glycosaminoglycan widely distributed throughout various tissues of the human body. It stands out from other glycosaminoglycans as it lacks sulfation and can attain considerable size: the average human synovial HA molecule weighs about 7 million Dalton (Da), equivalent to roughly 20,000 disaccharide monomers; although some sources report a lower range of 3–4 million Da. In recent years, HA has garnered significant attention in the field of rheumatology due to its involvement in joint lubrication, cartilage maintenance, and modulation of inflammatory and/or immune responses. This review aims to provide a comprehensive overview of HA’s involvement in rheumatology, covering its physiology, pharmacology, therapeutic applications, and potential future directions for enhancing patient outcomes. Nevertheless, the use of HA therapy in rheumatology remains controversial with conflicting evidence regarding its efficacy and safety. In conclusion, HA represents a promising therapeutic option to improve joint function and alleviate inflammation and pain.

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