Medical Treatment for Androgenetic Alopecia

Panchaprateep, Ratchathorn

doi:10.1055/a-2196-4713

Cited by 2 publications

(2 citation statements)

References 109 publications

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“…Although these drugs improve patients with androgenetic alopecia (AGA), researchers continue to search for more effective alternatives and limited side effects. For these reasons, due to the significant ability of PRP to promote tissue regeneration, new treatment protocols have been developed using this bioproduct, demonstrating efficacy in the treatment of alopecia, especially in AGA [ 57 ].…”

Section: Aesthetic Conditionsmentioning

confidence: 99%

The Biological Role of Platelet Derivatives in Regenerative Aesthetics

Santos,

Lana,

Santos

et al. 2024

IJMS

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Bioproducts derived from platelets have been extensively used across various medical fields, with a recent notable surge in their application in dermatology and aesthetic procedures. These products, such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), play crucial roles in inducing blood vessel proliferation through growth factors derived from peripheral blood. PRP and PRF, in particular, facilitate fibrin polymerization, creating a robust structure that serves as a reservoir for numerous growth factors. These factors contribute to tissue regeneration by promoting cell proliferation, differentiation, and migration and collagen/elastin production. Aesthetic medicine harnesses these effects for diverse purposes, including hair restoration, scar treatment, striae management, and wound healing. Furthermore, these biological products can act as adjuvants with other treatment modalities, such as laser therapy, radiofrequency, and microneedling. This review synthesizes the existing evidence, offering insights into the applications and benefits of biological products in aesthetic medicine.

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Section: Aesthetic Conditionsmentioning

confidence: 99%

The Biological Role of Platelet Derivatives in Regenerative Aesthetics

Santos,

Lana,

Santos

et al. 2024

IJMS

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“…[1][2][3] Clinically, male AGA mainly shows "horseshoe-shaped" hair loss, whereas female AGA appears to have "Christmas tree-shaped" hair loss; they both greatly affect patients' quality of life, especially due to emotional distress, including low self-esteem, anxiety, depression, embarrassment, shame, decreased sense of value, excessive self-concern, etc. [4][5][6][7] Currently, a multitude of treatment modalities exist for AGA, including oral finasteride and topical minoxidil; however, with advancements in AGA knowledge and related technologies, new methods, such as low-level laser therapy (LLLT) 8 and concentrated growth factor (CGF) injections, 9 have emerged. In fact, the latter two treatment options were well accepted by patients who were reluctant to the traditional oral and topical treatment, for example, pregnant women or patients allergic to certain types of medicine.…”

Section: Introductionmentioning

confidence: 99%

Higher percentage of CD34+ stem cells and elevated efficacy in androgenetic alopecia treatment observed in CGF prepared from 640 nm laser‐pretreated blood: A preliminary study

Gao,

Xiao,

et al. 2024

J of Cosmetic Dermatology

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BackgroundConcentrated growth factor (CGF) injection has proven effective in treating androgenetic alopecia (AGA). The primary mechanism of CGF in treating AGA is thought to be the CD34+ stem cells and platelets‐associated growth factors being injected into the scalp. CGF efficacy in treating AGA may rely on the activation level of these stem cells and platelets. The 640 nm laser is a United States Food and Drug Administration approved AGA treatment that activates follicle stem cells. Therefore, we hypothesize that pretreating CGF with a 640 nm laser may further activate CD34+ stem cells and platelets, thereby improving the efficacy of CGF in treating AGA.ObjectiveThis study aims to investigate whether 640 nm laser pretreated CGF (640CGF) has a greater effect in treating AGA than 640 nm laser non‐pretreated CGF (N640CGF) and evaluate whether 640 nm laser pretreatment changed CD34+ cell percentage.MethodsThis study enrolled 10 patients (8 male, 2 female) with AGA aged 18–60 years who received CGF injections. The 640CGF group was pretreated with a 640 nm laser at an energy density of 4 J/cm2, with a 30 cm irradiation distance for 30 min. Half of the scalp was treated with 640CGF, whereas the other half was treated with N640CGF. The injection was prepared by a doctor who did not know which blood tube had been pretreated. The treatment efficacy was evaluated using a trichoscope 1 month after injection.ResultsAll 10 (100%) patients participated in the follow‐up visit, and a higher quantity of new hairs was observed on the side injected with 640CGF than N640CGF (p = 0.019). Additionally, fewer malnourished hairs were observed on the 640CGF pretreated side (p = 0.015). No serious adverse events were reported.ConclusionsA higher percentage of CD34+ stem cells and improved efficacy in AGA treatment could be observed with CGF prepared from 640 nm laser‐pretreated blood.

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Medical Treatment for Androgenetic Alopecia

Cited by 2 publications

References 109 publications

The Biological Role of Platelet Derivatives in Regenerative Aesthetics

The Biological Role of Platelet Derivatives in Regenerative Aesthetics

Higher percentage of CD34+ stem cells and elevated efficacy in androgenetic alopecia treatment observed in CGF prepared from 640 nm laser‐pretreated blood: A preliminary study

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