Medical therapy for nephrolithiasis: State of the art

Sorokin, Igor; Pearle, Margaret S.

doi:10.1016/j.ajur.2018.08.005

Cited by 24 publications

(18 citation statements)

References 141 publications

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“…There are a variety of treatment options for KSD including open surgery, percutaneous nephrolithotomy, super-mini percutaneous nephrolithotomy, ureteroscopy, extracorporeal shock wave lithotripsy and conservative intervention/measures [23-28]. Despite satisfactory outcomes after intervention, the recurrence of KSD is dismally high [29-31].…”

Section: Introductionmentioning

confidence: 99%

A Retrospective Study of Kidney Stone Recurrence in Adults

et al. 2019

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Background Nephrolithiasis or kidney stone disease (KSD) is a common disorder worldwide. Despite the availability of a variety of effective management strategies, KSD recurrence remains a problem. In the present study, we investigated the KSD recurrence after the treatment of the first stone episode. Methods Medical records of all patients who had KDS treated in our department from January 2012 to January 2016 were retrospectively reviewed. A total of 146 patients who had KDS recurrence were identified. The demographic information, biochemical data, treatment methods, report of hydronephrosis severity and stone chemical compositions were collected and analyzed. Results We reported that: 1) Sixty four (43.8%) out of 146 patients with stone recurrence were overweight or obese; 2) Of all 146 patients with stone recurrence, 86 (58.9%) had hyperlipidemia, 77 (52.4%) had hyperuricemia and 64 (43.8%) had hyperglycemia; 3) Mini-invasive methods were mostly used for the treatment of the first stone episode; 4) The most chief complaint differed during the first episode and recurrence; 5) The number of patients who had grades 3 and 4 hydronephrosis was significantly lower during recurrence compared with that in the first stone episode; 6) Seventy nine (54.1%) patients with recurrence had stone of calcium oxalate. Conclusions Majority of patients with KSD recurrence have overweight/obesity, hyperlipidemia, hyperuricemia and hyperglycemia, indicating a role of metabolic disorders in stone recurrence. Mini-invasive methods are the mainstay for the management of the first stone episode. The degree of hydronephrosis is significantly reduced during stone recurrence, possibly due to increased awareness of the disease and thereafter the change of lifestyle in patients. Over half of recurrent stones are of calcium oxalate.

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Section: Introductionmentioning

confidence: 99%

A Retrospective Study of Kidney Stone Recurrence in Adults

et al. 2019

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“…In the past decade, several dietary factors that influence the incidence of hyperoxaluria or kidney stone were reported. [ 51–54 ] Among them, increased intake of calcium, potassium, magnesium, and fluid together with decreased intake of oxalate, animal protein, and vitamin C may be beneficial. [ 53 ] Vitamin B6 also attracted attention due to its role as an agxt1 cofactor, although the effects of B6 on kidney stone formation have not been consistent.…”

Section: Discussionmentioning

confidence: 99%

Effect of Vitamin B2‐Deficient Diet on Hydroxyproline‐ or Obesity‐Induced Hyperoxaluria in Mice

Uebanso

Suyama

Shimohata

et al. 2021

Molecular Nutrition Food Res

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Scope Hyperoxaluria is a major cause of kidney stone disease. Around half of the oxalate in mammals is supplied from the diet and the other half is endogenously synthesized from glyoxylate. Reduction of hepatic glycolate oxidase (GO) activity is one approach to reduce endogenous production of oxalate. However, there are currently few effective dietary approaches to reduce hepatic GO activity. Methods and Results In the present study, it is investigated whether restriction of dietary vitamin B2 (VB2) can reduce hepatic GO activity and oxalate excretion in mice with hyperoxaluria induce by hydroxyproline (Hyp) or obesity. It is found that VB2 restriction significantly reduces hepatic GO activity in both the Hyp‐ and obesity‐induced model of hyperoxaluria in mice. However, VB2 restriction reduces urinary oxalate excretion only in the Hyp‐treated mice and not the obese mice. This difference could be due to the contribution of endogenous oxalate production that manifests as increased hepatic GO activity in Hyp‐treated mice but not obese mice. Conclusion Together these results suggest that VB2 restriction could be a new dietary approach to improve hyperoxaluria when endogenous production of oxalate is increased.

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“…The goal of treatment in patients with kidney stones is to overcome pain, remove blockages, remove existing stones, and prevent recurrence of stone formation. [27][28][29] Staghorn stones cause squamous metaplasia and uroepithelium dysplasia. Kidney stone coexistence has been reported in 18-100% of cases of kidney SCC.…”

Section: Kidney Stonesmentioning

confidence: 99%

The role of intraoperative kidney mucosal biopsy on screening of squamous cell carcinoma of the kidney in nephrolithiasis patients with stones larger than 20 mm

Nugroho

Safriadi

Noegroho

2020

Journal of Clinical Urology

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Introduction: Renal pelvic squamous cell carcinoma is a very rare tumor, with a prevalence <1% of all urinary tract tumors, about 0.5–8% of all kidney tumors, and the average age is 50–70 years. Although the incidence of renal squamous cell carcinoma is less common than renal cell carcinoma and renal transitional cell carcinoma, due to its more aggressive nature renal squamous cell carcinoma is often found intraoperatively and is already in an advanced stage or metastasis. The relevant medical history of squamous cell carcinoma is pyelonephritis, chronic nephrolithiasis, and a history of kidney stone surgery. Data which was obtained from previous research at Hasan Sadikin Hospital, from January 2014–December 2017, found the incidence of renal squamous cell carcinoma from nephrectomy procedures was 6%. Methods: This study was a cross-sectional study with a correlative analytic study, samples were taken consecutively from biopsy of kidney mucosa intraoperatively in hospitalized patients with kidney stones with size larger than 20 mm at the Department of Urology, Hasan Sadikin Hospital Bandung, which performed open kidney surgery or percutaneous nephrolithotomy from January–May 2019. Results: The number of samples in this study were from 30 patients, consisting of 16 males and 14 females. Five patients underwent open kidney surgery and 25 patients underwent percutaneous nephrolithotomy surgery, with an average of age of 49.5±11.8 years and 63.3% of patients were aged from 40–60 years. In this study, one patient (3.3%) showed squamous cell carcinoma of the kidney, a 57-year-old male patient with a left staghorn kidney stone who underwent left percutaneous nephrolithotomy surgery. Conclusion: There is a benefit for intraoperative kidney mucosal biopsy as a screening for squamous cell carcinoma of the kidney in nephrolithiasis patients with stones larger than 20 mm. Level of evidence: 3

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Medical therapy for nephrolithiasis: State of the art

Cited by 24 publications

References 141 publications

A Retrospective Study of Kidney Stone Recurrence in Adults

A Retrospective Study of Kidney Stone Recurrence in Adults

Effect of Vitamin B2‐Deficient Diet on Hydroxyproline‐ or Obesity‐Induced Hyperoxaluria in Mice

The role of intraoperative kidney mucosal biopsy on screening of squamous cell carcinoma of the kidney in nephrolithiasis patients with stones larger than 20 mm

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