“…Perish the thought experiment! A new syndrome is also described in this issue: ManuScript Rejection sYndrome or MiSeRY, a grief reaction almost everyone who has written a medical paper has experienced at some point, including your editor‐in‐chief (often) . Doctors are trained to be expert diagnostic detectives, and although more than 100 years have passed since his first story was published, Sherlock Holmes remains an inspiring figure, as discussed in this issue . You will also read about a medical miracle in Bethlehem associated with the birth of Jesus .…”