Medical reference dosimetry using EPR measurements of alanine: Development of an improved method for clinical dose levels.

Helt-Hansen, Jakob; Rosendal, Flemming; Kofoed, Inger Matilde; Andersen, C.E.

doi:10.1080/02841860802279725

Cited by 24 publications

(19 citation statements)

References 16 publications

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“…The EPR spectra obtained from gamma irradiated and plasma treated FCA films with the use of Bruker EMS104 EPR spectrum analyzer are shown in Figure . Both waveforms shown in Figure present typical ESR spectra of alanine radicals, as described in Refs . Fluoropolymer as well as the untreated alanine does not have significant amounts of free radicals and thus the resultant EPR signal of fluoropolymer is weak.…”

Section: Resultsmentioning

confidence: 99%

“…Fluoropolymer as well as the untreated alanine does not have significant amounts of free radicals and thus the resultant EPR signal of fluoropolymer is weak. After each treatment, detectable amounts of the stable alkyl free radical in alanine are created, shown as a fingerprint in Figure . On the other hand, XPS analysis shows that such an alkyl radical is not created on the FCA surfaces after each treatment.…”

Section: Resultsmentioning

confidence: 99%

“…The intercept of the fitted line in Figure (left) is 1.7 × 10 5 which is close to the measured EPR response of the untreated film at 1.4 × 10 5 . It is approximately 10 times smaller than the EPR values obtained for the irradiated FCA films, and thus the EPR signal of the untreated FCA film is weak, showing good agreements of the measured EPR signals of untreated alanine in literature …”

Section: Resultsmentioning

confidence: 99%

“…As for the low doses from 4 to 100 Gy, an improved method of processing alanine‐EPR data proposed in Ref . was used.…”

Section: Resultsmentioning

confidence: 99%

“…In other words, EPR can detect radicals and electronic defects in a material. Alanine‐EPR dosimetry for various kinds of ionizing radiation is well‐documented and standardized . Alanine is found to be a convenient material for establishing a quantitative link between an absorbed dose of radiation and DNA modification − or microbiological decontamination − caused by ionizing radiation, since the amination of an alanine molecule produces a stable alkyl free radical, CH 3 CHCOO − .…”

Section: Introductionmentioning

confidence: 99%

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Fluoropolymer coated alanine films treated by atmospheric pressure plasmas − In comparison with gamma irradiation

Kusano

Bardenshtein

Morgen

2017

Plasma Processes & Polymers

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Fluoropolymer coated alanine films are treated by a dielectric barrier discharge and a gliding arc at atmospheric pressure as well as with gamma irradiation. The film surfaces and the underlying bulk materials are characterized before and after each treatment. The fluorine content decreases and the oxygen content increases at the fluoropolymer surfaces, while deposition of specific plasma energies in the alanine films is detected by electron paramagnetic resonance spectroscopy, indicating that not only the fluoropolymer surfaces but also the bulk alanine materials are modified. Differences of surface and bulk modification effects between the two plasma treatments are discussed in detail.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…As for the low doses from 4 to 100 Gy, an improved method of processing alanine‐EPR data proposed in Ref . was used.…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Fluoropolymer coated alanine films treated by atmospheric pressure plasmas − In comparison with gamma irradiation

Kusano

Bardenshtein

Morgen

2017

Plasma Processes & Polymers

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Clinical applications of alanine/electron spin resonance dosimetry

Baffa¹,

Kinoshita

2014

Radiat Environ Biophys

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This paper discusses the clinical applications of electron spin resonance (ESR) dosimetry focusing on the ESR/alanine system. A review of few past studies in this area is presented offering a critical overview of the challenges and opportunities for extending this system into clinical applications. Alanine/ESR dosimetry fulfills many of the required properties for several clinical applications such as water-equivalent composition, independence of the sensitivity for the energy range used in therapy and high precision. Improvements in sensitivity and the development of minidosimeters coupled with the use of a spectrometer of higher microwave frequency expanded the possibilities for clinical applications to the new modalities of radiotherapy (intensity-modulated radiation therapy and radiosurgery) and to the detection of low doses such as those present in some radiological image procedures.

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Characterization of phenolic pellets for ESR dosimetry in photon beam radiotherapy

Gallo

Iacoviello²,

Panzeca

et al. 2017

Radiat Environ Biophys

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» Download abstractWe report a study of the dosimetric features of phenolic compounds for applications in radiation therapy dosimetry of clinical photon beams by using ESR spectroscopy. After the optimization of the ESR readout parameters, basic dosimetric properties (such as intra-batch reproducibility, dose-response, sensitivity, linearity, dose rate dependence, tissueequivalence and signal stability) of laboratory-made phenolic dosimeters in form of pellets were investigated. Furthermore, these dosimeters were tested for measuring the depth dose profile of a 6 MV clinical photon beam. The results reported show that these dosimeters are promising materials for ESR dosimetric applications in radiation therapy.

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Medical reference dosimetry using EPR measurements of alanine: Development of an improved method for clinical dose levels.

Abstract: (2009) Medical reference dosimetry using EPR measurements of alanine: Development of an improved method for clinical dose levels., Acta Oncologica, 48:2, 216-222,

Cited by 24 publications

References 16 publications

Fluoropolymer coated alanine films treated by atmospheric pressure plasmas − In comparison with gamma irradiation

Fluoropolymer coated alanine films treated by atmospheric pressure plasmas − In comparison with gamma irradiation

Clinical applications of alanine/electron spin resonance dosimetry

Characterization of phenolic pellets for ESR dosimetry in photon beam radiotherapy

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