Medical procedures and the risk of iatrogenic hepatitis C infection: case-controlled study in north-eastern Poland

Chlabicz, Sławomir; Grzeszczuk, Anna; Prokopowicz, D

doi:10.1016/j.jhin.2004.06.014

Cited by 23 publications

(25 citation statements)

References 15 publications

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“…Previous studies in Pakistan, Poland, Italy and Turkey suggest that previous surgeries had a significant association with HCV infection (Mele et al. 2000; Chlabicz et al. 2004; Jaffery et al.…”

Section: Discussionmentioning

confidence: 94%

Case–control study of risk factors associated with hepatitis C virus infection among pregnant women in hospitals of Karachi‐Pakistan

Khan

Janjua

Akhtar

et al. 2008

Tropical Med Int Health

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Summaryobjective To identify risk factors for hepatitis C virus (HCV) infection among pregnant women seeking antenatal care in tertiary care hospitals of Karachi, Pakistan.methods We enrolled 119 cases and 238 controls. Cases were enzyme-linked immunosorbent assay (ELISA III) positive pregnant women for antibodies to HCV; controls were anti-HCV ELISA negative pregnant women.results The mean age of study subjects was 26 years (SD 5) ranging from 15 to 50 years. The mean number of pregnancies for cases was 4 (SD 3) and for controls was 3 (SD 2). Among cases an average number of injections in any month was 40%, history of hospitalization was 61% and household contact with jaundice or hepatitis was 35%. In the final multivariable logistic regression model, five or more gestations (aOR = 1.99; 95% CI = 1.08-3.33), ‡1 injection (aOR = 2.33; 95% CI = 1.38-3.91) per month, hospitalization (aOR = 1.78; 95% CI = 1.01-2.99) and household contact with jaundice ⁄ hepatitis (aOR = 3.32; 95% CI = 1.89-5.83) were independently associated with HCV.conclusion Iatrogenic exposure (health care injections, hospitalizations and gestations) is the major risk factor for transmission of HCV among pregnant women.keywords hepatitis C, risk factors, Pakistan

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Section: Discussionmentioning

confidence: 94%

Case–control study of risk factors associated with hepatitis C virus infection among pregnant women in hospitals of Karachi‐Pakistan

Khan

Janjua

Akhtar

et al. 2008

Tropical Med Int Health

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“…In our study, minor medical and dental procedures were strongly associated with recently acquired HCV infection (AOR, 5.8; 95% CI, 2.0‐18.5). Medical exposures were consistently associated with HCV infections in Poland . However, previous studies relied on prevalent rather than incident cases, which precluded the drawing of strong conclusions about current transmission patterns.…”

Section: Discussionmentioning

confidence: 99%

What weighs more—low compliance with self‐deferral or minor medical procedures? Explaining the high rate of hepatitis C virus window‐period donations in Poland

et al. 2017

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Background Since the introduction of nucleic acid testing (NAT) for routine blood donor screening, hepatitis C virus (HCV) RNA-only detection rates reported from Poland have been higher than in most other European countries. Methods To examine the factors likely contribute to these window-period donations, we conducted a case-control study among 47 recently HCV-infected blood donors, who gave blood between July 2002 and June 2014, with 141 controls matched by age, gender and donation dates. Firth-corrected conditional logistic regression models were fitted to estimate adjusted odds ratios (AORs) and 95% confidence intervals (CIs). Adjusted population attributable fractions (PAF) were calculated, based on the distribution of exposure among the cases. Results In a multivariate analysis, recent exposures in health care environments not routinely ascertained through pre-donation questionnaires, were strongly associated with recently-acquired HCV infection. These exposures included minor medical procedures and dental procedures in the preceding 6 months, AOR = 5.77 (CI = 2.01, 18.53). More important, however, based on PAF were behavioral deferrable risks that went unreported at the time of donation, such as high-risk sexual behaviors in the preceding 6 months (PAF=34%), or lifetime histories of drug use (PAF=28%). Conclusions This study raises questions about the effectiveness of deferral policy in excluding high-risk individuals. In addition, it provides further evidence supporting short, temporal deferrals for small medical procedures and dental treatments in Poland.

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“…Liver failure due to HCV infection is the most frequent reason for liver transplantation in Poland (Malkowski et al, 2005). Although the data on HCV epidemiology in Eastern Europe are scarce, the available literature and expert opinions indicate that nosocomial infections prevail and intravenous drug use (IVDU) remains an important mode of HCV acquisition (Chlabicz et al, 2004;Naoumov, 1999).…”

Section: Introductionmentioning

confidence: 99%

Changing HCV genotypes distribution in Poland—Relation to source and time of infection

Chlabicz¹,

Flisiak²,

Kowalczuk³

et al. 2008

Journal of Clinical Virology

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Medical procedures and the risk of iatrogenic hepatitis C infection: case-controlled study in north-eastern Poland

Cited by 23 publications

References 15 publications

Case–control study of risk factors associated with hepatitis C virus infection among pregnant women in hospitals of Karachi‐Pakistan

Case–control study of risk factors associated with hepatitis C virus infection among pregnant women in hospitals of Karachi‐Pakistan

What weighs more—low compliance with self‐deferral or minor medical procedures? Explaining the high rate of hepatitis C virus window‐period donations in Poland

Changing HCV genotypes distribution in Poland—Relation to source and time of infection

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