Medical Plants and Nutraceuticals for Amyloid-β Fibrillation Inhibition

Witter, Steffi; Witter, Raiker; Vilu, Raivo; Samoson, Ago

doi:10.3233/adr-180066

Cited by 11 publications

(10 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SFS extracts were prepared with maceration with mortar and pestle (3 g plant material with 30 ml solvent) and were directly used after [10] [23].…”

Section: Extraction Methodsmentioning

confidence: 99%

“…The LED-based illumination system (LED Company, Estonia) provided a light wavelength distribution of 380 -780 nm. Defined light conditions were achieved for 24 hours: daylight from 8:00 -19:59 and darkness from 20:00 -7:59 [10] [23].…”

Section: S Witter Et Almentioning

confidence: 99%

“…GK LC-MS and GC-MS data are listed in Table 3 [10] [23] [57] [58] (limited to the main abundance peak areas with a Q Score of 100%; with a threshold around 30%) show more compounds than expected: about 5.000 out of approximately 10.000 components and fragments were identified based on a Q Score of 80% -100%. Hereby, approximate thousand compounds were specified.…”

Section: Centella Asiatica (Gotu Kola Gk)mentioning

confidence: 99%

“…Such herbal medicines and medical plant extracts are complex bioactive compound mixtures for which an improved insight with specifications and proof-of-effectiveness of the ingredients is recommended [6] In this study we performed an ingredients' screening of promising Ayurvedic plants-Withania somnifera, Centella asiatica, and Bacopa monnieri-to make first steps gaining insight into the prevention or treatment of diverse mental disorders like Alzheimer, Parkinson, Schizophrenia, and Depressions [10]. Extracts were selected from eight traditional Indian medicines-used since more than 2000 years-for a possible Alzheimer treatment and are known for several positive phytotherapeutic effects on the human brain and body without negative post-, adverse or after effects to the treated individuals (positive memory influence, stress reduction, mental health regeneration and reduction of anxiety), and have been recommended in several medical studies [11]- [22] which we previously investigated by in vitro Amyloid Beta fibrillation inhibition measurements by luminescence spectroscopy [10] [23]. Here, we applied Gas Chromatography-Mass Spectrometry (GC-MS), Liquid Chromatography-Mass Spectrometry (LC-MS) and Spectral Fluorescence Signature (SFS) on related nutraceuticals and plant extracts.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Compound’s Pre-Screening of Withania somnifera, Bacopa monnieri and Centella asiatica Extracts

Witter¹,

Arju²,

Junusova³

et al. 2020

JBM

Self Cite

View full text Add to dashboard Cite

Spectral fluorescence signature, Gas Chromatography-Mass Spectrometry and Liquid Chromatography-Mass Spectrometry for identification of chemical and bioactive compounds were applied to study the plant extracts of Withania somnifera, Centella asiatica and Bacopa monnieri which are related to the possible treatment of mental diseases as Alzheimer, Parkinson and Depression. These plants are known for different positive phytotherapeutic effects on the human brain without negative post-, adverse or after effects to the treated individuals, and have been recommended in several medical studies. Therefore, we selected these plants for further analysis, based on the inhibition results of in vitro Amyloid Beta fibrillation tests made by previous measurements. With this study a first screening of the complex plant extract mixtures was performed, to get an initial overview about known and unknown ingredients. In all three plants, similar main compounds were identified, however in different quality and quantity. These may provide substantial information on which compound combinations might be mainly responsible for the positive effects and should be further investigated being responsible for reducing the fibrillation process of Amyloid Beta.

show abstract

“…SFS extracts were prepared with maceration with mortar and pestle (3 g plant material with 30 ml solvent) and were directly used after [10] [23].…”

Section: Extraction Methodsmentioning

confidence: 99%

Section: S Witter Et Almentioning

confidence: 99%

Section: Centella Asiatica (Gotu Kola Gk)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Compound’s Pre-Screening of Withania somnifera, Bacopa monnieri and Centella asiatica Extracts

Witter¹,

Arju²,

Junusova³

et al. 2020

JBM

Self Cite

View full text Add to dashboard Cite

show abstract

“…For example, many designed drugs (pegylated copolymer and synthesized liposomes), as well as natural compounds (plant extracts, such as polyphenols, and marine-derived carotenoids, such as astaxanthin and fucoxanthin) were identified using ThT assays [40][41][42][43]68]. The role of cellular actors, such as chaperone, in fibrillization inhibition was also examined using a ThT assay [69]. Another emerging idea about how to prevent AD is rather to avoid the formation of toxic oligomers.…”

Section: Pharmacological Development Targeting Aβ Peptidesmentioning

confidence: 99%

Deconstructing Alzheimer’s Disease: How to Bridge the Gap between Experimental Models and the Human Pathology?

Vignon

Salvador-Prince

Lehmann

et al. 2021

IJMS

View full text Add to dashboard Cite

Discovered more than a century ago, Alzheimer’s disease (AD) is not only still present in our societies but has also become the most common dementia, with 50 million people worldwide affected by the disease. This number is expected to double in the next generation, and no cure is currently available to slow down or stop the disease progression. Recently, some advances were made due to the approval of the aducanumab treatment by the American Food and Drug Administration. The etiology of this human-specific disease remains poorly understood, and the mechanisms of its development have not been completely clarified. Several hypotheses concerning the molecular mechanisms of AD have been proposed, but the existing studies focus primarily on the two main markers of the disease: the amyloid β peptides, whose aggregation in the brain generates amyloid plaques, and the abnormally phosphorylated tau proteins, which are responsible for neurofibrillary tangles. These protein aggregates induce neuroinflammation and neurodegeneration, which, in turn, lead to cognitive and behavioral deficits. The challenge is, therefore, to create models that best reproduce this pathology. This review aims at gathering the different existing AD models developed in vitro, in cellulo, and in vivo. Many models have already been set up, but it is necessary to identify the most relevant ones for our investigations. The purpose of the review is to help researchers to identify the most pertinent disease models, from the most often used to the most recently generated and from simple to complex, explaining their specificities and giving concrete examples.

show abstract

Ethnobotanical significance of medicinal plants: Beta‐amyloid and tau aggregation inhibitors against Alzheimer's disease

Ganapathy

Haripriya

Acharya

et al. 2023

J Biochem & Molecular Tox

View full text Add to dashboard Cite

Among the various neurodegenerative disorders, Alzheimer's disease (AD) is identified as one of primary causes of dementia in the elderly, which progresses slowly leading to cognitive decline and ability to function independently. Although various pathological mechanisms have been proposed, the exact mechanism is not yet elucidated. Numerous processes such as old age, mitochondrial dysfunction, and genetics lead to the aggregation of beta-amyloid (Aβ) as amyloid plaques and tau proteins as neurofibrillary tangles in the neurons leading to their death and destruction, finally leading to AD. The current treatment measures can only temporarily improve the symptoms, slowing cognitive decline without any effect on AD pathology for better therapeutic effect. Furthermore, the high failure rates of a number of drugs during clinical trials due to their side effects has led the researchers to focus on alternative sources for drug development. As natural ingredients were considered the primary line of treatment in the olden days, and as several medicinal plant products are also proven as effective AD targets, it will be wise to investigate those with significant ethnobotanical value as potential neuroprotectives, nootropics or memory boosters. Throughout the study, propanoids, glycosides, iridoids, carotenoids and flavonoids that show potential anti-inflammatory, antioxidant, and anti-cholinesterase were also found to be inhibitors of Aβ and tau aggregation, where Saikosaponin C, Fisetin, and Morin can act as dual inhibitors. The review provides an insight in the need for proper and complete scientific evaluation of these ethnobotanically useful medicinal plants to be identified as potential leads in AD therapy.

show abstract

Medical Plants and Nutraceuticals for Amyloid-β Fibrillation Inhibition

Cited by 11 publications

References 64 publications

Compound’s Pre-Screening of <i>Withania somnifera</i>, <i>Bacopa monnieri</i> and <i>Centella asiatica</i> Extracts

Compound’s Pre-Screening of <i>Withania somnifera</i>, <i>Bacopa monnieri</i> and <i>Centella asiatica</i> Extracts

Deconstructing Alzheimer’s Disease: How to Bridge the Gap between Experimental Models and the Human Pathology?

Ethnobotanical significance of medicinal plants: Beta‐amyloid and tau aggregation inhibitors against Alzheimer's disease

Contact Info

Product

Resources

About

Medical Plants and Nutraceuticals for Amyloid-β Fibrillation Inhibition

Cited by 11 publications

References 64 publications

Compound’s Pre-Screening of &lt;i&gt;Withania somnifera&lt;/i&gt;, &lt;i&gt;Bacopa monnieri&lt;/i&gt; and &lt;i&gt;Centella asiatica&lt;/i&gt; Extracts

Compound’s Pre-Screening of &lt;i&gt;Withania somnifera&lt;/i&gt;, &lt;i&gt;Bacopa monnieri&lt;/i&gt; and &lt;i&gt;Centella asiatica&lt;/i&gt; Extracts

Deconstructing Alzheimer’s Disease: How to Bridge the Gap between Experimental Models and the Human Pathology?

Ethnobotanical significance of medicinal plants: Beta‐amyloid and tau aggregation inhibitors against Alzheimer's disease

Contact Info

Product

Resources

About

Compound’s Pre-Screening of <i>Withania somnifera</i>, <i>Bacopa monnieri</i> and <i>Centella asiatica</i> Extracts

Compound’s Pre-Screening of <i>Withania somnifera</i>, <i>Bacopa monnieri</i> and <i>Centella asiatica</i> Extracts