Medical management of three workers following a radiation exposure incident

Ra, House; Se, Sax; Er, Rumack; Dl, Holness

doi:10.1002/ajim.4700220210

Cited by 3 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The data of the current study indicate that whole-body radiation exposure might be such an environmental risk factor, and therefore has implications for emergency responders, such as those attending to the Fukushima nuclear accident in 2011 or persons exposed during a nuclear conflict. In fact, human radiation exposure related to accidents or subsequent cleanup efforts at nuclear power plants are consistent with a post-traumatic stress response and increased PTSD risk following whole-body irradiation (House et al, 1992; Havenaar et al, 1997; Rahu et al, 2006; Shigemura et al, 2012). In addition to nuclear accidents, potential radiation exposure is also pertinent to military missions and dirty bomb scenarios (Chin, 2007; Giesecke et al, 2012; Obenaus et al, 2012).…”

Section: Discussionmentioning

confidence: 88%

Impairment in Extinction of Contextual and Cued Fear Following Post-Training Whole-Body Irradiation

Marzulla

Raber

2014

Front. Behav. Neurosci.

View full text Add to dashboard Cite

Because of the use of radiation in cancer therapy, the risk of nuclear contamination from power plants, military conflicts, and terrorism, there is a compelling scientific and public health interest in the effects of environmental radiation exposure on brain function, in particular hippocampal function and learning and memory. Previous studies have emphasized changes in learning and memory following radiation exposure. These approaches have ignored the question of how radiation exposure might impact recently acquired memories, which might be acquired under traumatic circumstances (cancer treatment, nuclear disaster, etc.). To address the question of how radiation exposure might affect the processing and recall of recently acquired memories, we employed a fear conditioning paradigm wherein animals were trained, and subsequently irradiated (whole-body X-ray irradiation) 24 h later. Animals were given 2 weeks to recover, and were tested for retention and extinction of hippocampus-dependent contextual fear conditioning or hippocampus-independent cued fear conditioning. Exposure to irradiation following training was associated with reduced daily increases in body weights over the 22-days of the study and resulted in greater freezing levels and aberrant extinction 2 weeks later. This was also observed when the intensity of the training protocol was increased. Cued freezing levels and measures of anxiety 2 weeks after training were also higher in irradiated than sham-irradiated mice. In contrast to contextual freezing levels, cued freezing levels were even higher in irradiated mice receiving 5 shocks during training than sham-irradiated mice receiving 10 shocks during training. In addition, the effects of radiation on extinction of contextual fear were more profound than those on the extinction of cued fear. Thus, whole-body irradiation elevates contextual and cued fear memory recall.

show abstract

Section: Discussionmentioning

confidence: 88%

Impairment in Extinction of Contextual and Cued Fear Following Post-Training Whole-Body Irradiation

Marzulla

Raber

2014

Front. Behav. Neurosci.

View full text Add to dashboard Cite

show abstract

“…These data indicate that whole body X ray irradiation causes persistent alterations in the fear response and activity levels in a novel environment, while the effects on body weight seem more transient. These data are pertinent to human radiation exposure related to nuclear accidents or subsequent cleanup efforts at nuclear power plants [14–17], military missions, and dirty bomb scenarios [3, 18, 19]. …”

Section: Discussionmentioning

confidence: 99%

Enhanced cued fear memory following post-training whole body irradiation of 3-month-old mice

Weber

Akinyeke

Raber

2017

Behavioural Brain Research

View full text Add to dashboard Cite

Typically, in studies designed to assess effects of irradiation on cognitive performance the animals are trained and tested for cognitive function following irradiation. Little is known about post-training effects of irradiation on cognitive performance. In the current study, 3-month-old male mice were irradiated with X-rays 24 hours following training in a fear conditioning paradigm and cognitively testing starting two weeks later. Average motion during the extinction trials, measures of anxiety in the elevated zero maze, and body weight changes over the course of the study were assessed as well. Exposure to whole body irradiation 24 hours following training in a fear conditioning resulted in greater freezing levels 2 weeks after training. In addition, motion during both contextual and cued extinction trials was lower in irradiated than sham-irradiated mice. In mice trained for cued fear conditioning, activity levels in the elevated zero maze 12 days after sham-irradiation or irradiation were also lower in irradiated than sham-irradiated mice. Finally, the trajectory of body weight changes was affected by irradiation, with lower body weights in irradiated than sham-irradiated mice, with the most profound effect 7 days after training. These effects were associated with reduced c-Myc protein levels in the amygdala of the irradiated mice. These data indicate that whole body X ray irradiation of mice at 3 months of age causes persistent alterations in the fear response and activity levels in a novel environment, while the effects on body weight seem more transient.

show abstract

“…The number of empirical knowledge or methodologies have been known and established. It is well known that various clinical symptoms tightly associated with ionizing irradiation exposure is called ARS (Acute Radiation Sickness/Sign/Syndrome) (House et al, 1992;Anno et al, 2003;Waselenko et al, 2004;Blakely et al, 2005) (for example skin rash or reddish, skin barn, leukopenia, purpura, alopecia, diarrhea or nausea/vomiting, dizziness, seizures, loss of consciousness and others appears after irradiation exposure as dose dependent manner). Dose dependency of these symptoms is tightly associated with the radiation sensitivity of the responsible organs/tissues, i.e.…”

Section: Biodosimetry For Irradiation Exposure Eventmentioning

confidence: 99%

Cytogenetic biodosimetry for accidental emergency irradiation exposure preparedness, in particular merit of the use of drug-induced premature chromosome condensation (PCC) with calyculin A

Gotoh¹

2013

Atlas of Genetics and Cytogenetics in Oncology and Haematology

View full text Add to dashboard Cite

show abstract

Medical management of three workers following a radiation exposure incident

Cited by 3 publications

References 8 publications

Impairment in Extinction of Contextual and Cued Fear Following Post-Training Whole-Body Irradiation

Impairment in Extinction of Contextual and Cued Fear Following Post-Training Whole-Body Irradiation

Enhanced cued fear memory following post-training whole body irradiation of 3-month-old mice

Cytogenetic biodosimetry for accidental emergency irradiation exposure preparedness, in particular merit of the use of drug-induced premature chromosome condensation (PCC) with calyculin A

Contact Info

Product

Resources

About