Medical Malpractice and Corticosteroid Use

Nash, John J.; Nash, Amanda G.; Leach, Matthew E.; Poetker, David M.

doi:10.1177/0194599810390470

Cited by 78 publications

(26 citation statements)

References 14 publications

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“…Glucocorticoid therapy is accompanied by many side effects (7), such as infection that accompanies attained immunodeficiency due to chronic steroid use (8). Therefore, there is a need for alternative and supplementary anti-AWR drugs with high efficacy and minimal side effects.…”

mentioning

confidence: 99%

The Antimalarial Drug Artesunate Inhibits Primary Human Cultured Airway Smooth Muscle Cell Proliferation

Tan¹,

Ong²,

Chang³

et al. 2014

Am J Respir Cell Mol Biol

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Airway smooth muscle (ASM) cell hyperplasia contributes to airway wall remodeling (AWR) in asthma. Glucocorticoids, which are used as first-line therapy for the treatment of inflammation in asthma, have limited impact on AWR, and protracted usage of high doses of glucocorticoids is associated with an increased risk of side effects. Moreover, patients with severe asthma often show reduced sensitivity to glucocorticoids. Artesunate, a semisynthetic artemisinin derivative used to treat malaria with minimal toxicity, attenuates allergic airway inflammation in mice, but its impact on AWR is not known. We examined the effects of artesunate on ASM proliferation in vitro and in vivo. Primary human ASM cells derived from nonasthmatic donors were treated with artesunate before mitogen stimulation. Artesunate reduced mitogen-stimulated increases in cell number and cyclin D1 protein abundance but had no significant effect on ERK1/2 phosphorylation. Artesunate, but not dexamethasone, inhibited phospho-Akt and phospho-p70 S6K protein abundance. Artesunate, but not dexamethasone, inhibited mitogen-stimulated increases in cell number, cyclin D1, and phospho-Akt protein abundance on ASM cells derived from asthmatic donors. In a murine model of allergic asthma, artesunate reduced the area of a-smooth muscle actin-positive cells and decreased cyclin D1 protein abundance. Our study provides a basis for the future development of artesunate as a novel anti-AWR agent that targets ASM hyperplasia via the PI3K/Akt/p70 S6K pathway and suggests that artesunate may be used as combination therapy with glucocorticoids.

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mentioning

confidence: 99%

The Antimalarial Drug Artesunate Inhibits Primary Human Cultured Airway Smooth Muscle Cell Proliferation

Tan¹,

Ong²,

Chang³

et al. 2014

Am J Respir Cell Mol Biol

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“…16,23,24,30,[48][49][50] Enhanced communication may improve patient satisfaction as well as minimize the risk of medicolegal action should an adverse event occur, and such communication should include providing patient education materials written at an appropriate level with nonmedical jargon to facilitate patient comprehension. 48,[51][52][53][54][55] The use of image guidance systems (IGSs) in ESS has proliferated over the past decade, although there are few studies showing that its use definitively decreases complications. A systematic review of the literature by Ramakrishnan and colleagues 56 noted that most evidence-based recommendations regarding the use of IGSs were based on limited literature, concluding that its use should be considered on a case-by-case basis.…”

Section: Complications In Crs Therapymentioning

confidence: 99%

Pitfalls in Sinus Surgery

Svider

Baredes

Eloy

2015

Otolaryngologic Clinics of North America

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“…Medical detail within each case varies and we are limited to the information provided in the case descriptions. Despite these limitations, Westlaw has been utilized in many medico-legal analyses [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] and we feel that this study provides a unique analysis of the available court records to identify common causes of malpractice in this procedure.…”

Section: Revised -Unmarkedmentioning

confidence: 99%