Medical Investigation of Retinal Vascular Occlusion

Ellis, Catherine; Hamer, Diana; Hunt, Ryan; Lever, A.F.; Lever, Rosemary; Peart, W. S.; Walker, Sinead

doi:10.1136/bmj.2.5417.1093

Cited by 39 publications

(15 citation statements)

References 14 publications

(20 reference statements)

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“…Secondly, and perhaps more importantly, is the young age of our patient at the time CRVO developed. Retinal vein occlusion is almost exclusively a disease of middle and later life; two series reporting a total of 160 patients with CRVO failed to find a single occurrence before the third decade (11,12). Thirdly, we were unable to identify any other factors such as hypertension or erythrocytosis, which may be important in causing CRVO (1 1).…”

Section: Discussionmentioning

confidence: 90%

Central retinal vein occlusion complicating systemic lupus erythematosus

Silverman

Lubeck

Briney

1978

Arthritis & Rheumatism

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Retinal lesions occur in 25 to 30% of patients with systemic lupus erythematosus (SLE). Visual loss, however, is rare. A patient who developed central retinal vein occlusion and blindness during the course of active SLE is described. The pertinent literature is reviewed with attention to possible pathophysiologic mechanisms.Several series have documented the occurrence of ocular disease in systemic lupus erythematosus (SLE) (1-3). Virtually any structure of the eye may be involved by an inflammatory process as evidenced by reports of conjunctivitis, episcleritis, uveitis, and retinitis (4). Moreover, these disorders can occur in the absence of hypertension, diabetes, uremia, or anti-malarial therFrom the

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Section: Discussionmentioning

confidence: 90%

Central retinal vein occlusion complicating systemic lupus erythematosus

Silverman

Lubeck

Briney

1978

Arthritis & Rheumatism

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“…Ellis et al [14] found carcinomas in some of their RVO cases but no definite relationship could be established. Similarly, Kohner and Cappin [42] found no evidence to suggest that malignancy contributes to the development of CRVO.…”

Section: Oncologic Diseasesmentioning

confidence: 86%

Hematologic abnormalities associated with various types of retinal vein occlusion

Hayreh

Zimmerman

Podhajsky

2002

Graefe's Arch Clin Exp Ophthalmol

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Our study showed that a variety of hematologic abnormalities may be seen in association with different types of RVO, and any generalization about these disorders applied to all RVO patients may be misleading. The evidence of our study and in the literature indicates that there is no good reason why all patients with RVO should be subjected to extensive, expensive, special hematologic and hypercoagulability investigations, unless, of course, there is some clear indication; the routine, inexpensive hematologic evaluation is usually sufficient for RVO patients. Treatment with anticoagulants or platelet anti-aggregating agents may adversely influence the visual outcome, without any evidence of protective or beneficial effect.

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“…However, dissimilarities with arterial disease exist. Ellis et al found that 51% of patients with vein occlusion smoked compared with 40% of controls but that all patients with central retinal artery occlusion smoked 54. Carotid artery disease is associated with retinal artery occlusion but not with CRVO 55.…”

Section: Pathogenesismentioning

confidence: 99%

Central retinal vein occlusion: what's the story?

Williamson

1997

British Journal of Ophthalmology

107

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Central retinal vein occlusion (CRVO) has been a profitable area of study for many investigators. Shameful then that we still do not understand its pathogenesis or know, definitively, how to treat the condition. Many questions still arise when CRVO is considered. Some of these are outlined in this perspective, hopefully as a guide to future investigation. TerminologyIf confusion over nomenclature is an indicator of confusion over the subject then CRVO is no diVerent. Leibreich in 1854 first described the clinical appearance of CRVO as 'retinal apoplexy' 1 followed closely by Leber in 1877 who preferred 'haemorrhagic retinitis'.2 We now use 'central retinal vein occlusion' assuming the presence of a blockage of the vein in the optic nerve head. Hayreh coined the phrases 'venous stasis retinopathy' for the milder types of CRVO and 'haemorrhagic retinopathy' for the more severe disease.

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Medical Investigation of Retinal Vascular Occlusion

Cited by 39 publications

References 14 publications

Central retinal vein occlusion complicating systemic lupus erythematosus

Central retinal vein occlusion complicating systemic lupus erythematosus

Hematologic abnormalities associated with various types of retinal vein occlusion

Central retinal vein occlusion: what's the story?

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