Medical importance of Sindbis virus in south-west Germany

Jöst, Hanna; Bürck-Kammerer, Simone; Hütter, Gero; Lattwein, Erik; Lederer, Sabine; Litzba, Nadine; Bock-Hensley, O.; Emmerich, Petra; Günther, Stephan; Becker, Norbert; Niedrig, Matthias; Schmidt‐Chanasit, Jonas

doi:10.1016/j.jcv.2011.08.002

Cited by 20 publications

(15 citation statements)

References 4 publications

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“…Culex species from central Europe are known as established vectors, able to transmit numerous viruses including West Nile, Sindbis and Usutu virus [14,15]. The results presented here indicate that the three most common Culex taxa in central Europe ( Cx.…”

Section: Discussionmentioning

confidence: 73%

Experimental transmission of Zika virus by mosquitoes from central Europe

et al. 2017

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Mosquitoes collected in Germany in 2016, including Culex pipiens pipiens biotype pipiens, Culex torrentium and Aedes albopictus, as well as Culex pipiens pipiens biotype molestus (in colony since 2011) were experimentally infected with Zika virus (ZIKV) at 18 °C or 27 °C. None of the Culex taxa showed vector competence for ZIKV. In contrast, Aedes albopictus were susceptible for ZIKV but only at 27 °C, with transmission rates similar to an Aedes aegypti laboratory colony tested in parallel.

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Section: Discussionmentioning

confidence: 73%

Experimental transmission of Zika virus by mosquitoes from central Europe

et al. 2017

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“…torrentium , the highly efficient enzootic vector of Sindbis virus (Lundström et al , , ), in northern Europe is interesting in the context of decades of outbreaks of infection in humans in Sweden (Ockelbo disease), Finland (Pogosta) and Russia (Karelian fever), and an absence of reported human cases in central and southern Europe (Lundström, ). It is possible that efficient enzootic transmission of Sindbis virus in bird populations, the prerequisite for further spread by the link vector Aedes cinereus to humans (Lundström, ; Jöst et al , ), requires a certain abundance of the enzootic vector Cx. torrentium .…”

Section: Discussionmentioning

confidence: 99%

The arbovirus vector Culex torrentium is more prevalent than Culex pipiens in northern and central Europe

Hesson

Rettich

Merdić

et al. 2013

Medical Vet Entomology

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Two species of arbovirus vector, Culex torrentium and Culex pipiens (Diptera: Culicidae), occur in several European countries, but difficulties in their accurate identification and discrimination have hampered both detailed and large-scale distribution and abundance studies. Using a molecular identification method, we identified to species 2559 larvae of Cx. pipiens/torrentium collected from 138 sites in 13 European countries ranging from Scandinavia to the Mediterranean coast. In addition, samples of 1712 males of Cx. pipiens/torrentium collected at several sites in the Czech Republic were identified to species based on the morphology of their hypopygia. We found that the two species occur together in large areas of Europe, and that Cx. torrentium dominates in northern Europe and Cx. pipiens dominates south of the Alps. The transition in dominance occurs in central Europe, where both species are roughly equally common. There was a strong correlation between the length of the growing season at different sites and occurrences of the two species. As the growing season increases, the proportion and detection of Cx. torrentium decrease, whereas those of Cx. pipiens increase. The present findings have important consequences for the interpretation of the results of studies on major enzootic and link-vectors of mosquito-borne bird-associated viruses (i.e. Sindbis, West Nile and Usutu viruses), especially in central Europe and Scandinavia.

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“…Human disease has mainly been reported from northern Europe and South Africa, but intriguingly, human SINV cases are not reported in Central Europe despite the fact that SINV can be detected in birds and mosquitoes ( Jost et al 2010, Jost et al 2011, Eiden et al 2014. The reason for this is unknown, but increased awareness and surveillance for SINV infection would be of importance.…”

Section: Discussionmentioning

confidence: 99%

Detection and Isolation of Sindbis Virus from Mosquitoes Captured During an Outbreak in Sweden, 2013

Bergqvist

Forsman

Larsson

et al. 2015

Vector-Borne and Zoonotic Diseases

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Mosquito-borne alphaviruses have the potential to cause large outbreaks throughout the world. Here we investigated the causative agent of an unexpected Sindbis virus (SINV) outbreak during August-September, 2013, in a previously nonendemic region of Sweden. Mosquitoes were collected using carbon dioxide-baited CDC traps at locations close to human cases. The mosquitoes were initially screened as large pools by SINVspecific quantitative RT-PCR, and the SINV-positive mosquitoes were species determined by single-nucleotide polymorphism (SNP) analysis, followed by sequencing the barcoding region of the cytochrome oxidase I gene. The proportion of the collected mosquitoes was determined by a metabarcoding strategy. By using novel strategies for PCR screening and genetic typing, a new SINV strain, Lövånger, was isolated from a pool of 1600 mosquitoes composed of Culex, Culiseta, and Aedes mosquitoes as determined by metabarcoding. The SINVpositive mosquito Culiseta morsitans was identified by SNP analysis and sequencing. After whole-genome sequencing and phylogenetic analysis, the SINV Lövånger isolate was shown to be most closely similar to recent Finnish SINV isolates. In conclusion, within a few weeks, we were able to detect and isolate a novel SINV strain and identify the mosquito vector during a sudden SINV outbreak.

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Medical importance of Sindbis virus in south-west Germany

Cited by 20 publications

References 4 publications

Experimental transmission of Zika virus by mosquitoes from central Europe

Experimental transmission of Zika virus by mosquitoes from central Europe

The arbovirus vector Culex torrentium is more prevalent than Culex pipiens in northern and central Europe

Detection and Isolation of Sindbis Virus from Mosquitoes Captured During an Outbreak in Sweden, 2013

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