Medical imaging in asthma

Blair, Deborah N.; Coppage, Lynn; Shaw, Coralie

doi:10.1097/00005382-198603000-00005

Cited by 18 publications

(5 citation statements)

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“…No clinically relevant correlation was found between the clinical and radiographic variables, in accordance with results of previous studies 24,25 . In humans with asthma, a correlation between radiographic abnormalities and clinical signs also could not be proven 30 . This result stresses the importance of reconciling radiographic abnormalities with medical history, physical examination and laboratory data at all times.…”

Section: Discussionsupporting

confidence: 85%

“…24,25 In humans with asthma, a correlation between radiographic abnormalities and clinical signs also could not be proven. 30 This result stresses the importance of reconciling radiographic abnormalities with medical history, physical examination and laboratory data at all times. Why the changes in clinical and radiographic variables failed to show a relevant correlation despite improvement in both scores over the study period remains unknown.…”

Section: )mentioning

confidence: 94%

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Correlation of clinical and radiographic variables in cats with lower airway disease

Gareis,

Hörner‐Schmid,

Zablotski

et al. 2023

Veterinary Internal Medicne

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BackgroundFeline lower airway disease (FLAD) is frequently associated with radiographic abnormalities.ObjectivesTo evaluate whether radiographic changes in cats with naturally occurring FLAD improve with treatment and if radiographic changes correlate with clinical signs.AnimalsTwenty‐four client‐owned cats newly diagnosed with FLAD, based on medical history, typical clinical signs, radiographic findings, and examination of bronchoalveolar lavage fluid, were included in the prospective study.MethodsAt 2 examination time points (days 0 and 60), an owner questionnaire, clinical examination, and thoracic radiography were carried out. Information from the questionnaire and clinical examination were evaluated on the basis of a 12‐point clinical score. Radiographs were assessed using a 10‐point radiographic score. Individual treatment was given to all cats over the study period, based on severity of the disease and compliance of the cat. Clinical and radiographic scores were compared statistically for both examination time points and evaluated for correlation.ResultsAll cats showed radiographic abnormalities at initial presentation. In addition to significant improvement in clinical variables, the total radiographic score improved significantly (P = .01) during the study period, with significant improvement in the severity of bronchial (P = .01) and interstitial lung pattern (P = .04). Improvement of the clinical and radiographic score was not correlated.Conclusion and Clinical ImportanceIn addition to clinical signs, repeated radiographic examination can be used as a diagnostic tool to evaluate treatment response in cats with FLAD.

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Section: Discussionsupporting

confidence: 85%

Section: )mentioning

confidence: 94%

Correlation of clinical and radiographic variables in cats with lower airway disease

Gareis,

Hörner‐Schmid,

Zablotski

et al. 2023

Veterinary Internal Medicne

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“…7–10 In humans with asthma, clinical signs and radiographs are poor indicators of airway inflammation resolution. 12–15 Despite the role inflammation plays in progression of airway remodeling, no studies in cats have determined if absence of clinical signs correlates with absence of airway inflammation. Furthermore, up to 23% of cats with lower airway disease have normal thoracic radiographs making the utility of this diagnostic test for documenting resolution of airway inflammation questionable.…”

mentioning

confidence: 99%

Subclinical airway inflammation despite high-dose oral corticosteroid therapy in cats with lower airway disease

Cocayne

Reinero

DeClue

2011

Journal of Feline Medicine and Surgery

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Management of feline chronic lower airway disease focuses on controlling clinical signs and decreasing airway inflammation. This retrospective study evaluated the correlation between the resolution of clinical signs in cats with lower airway disease receiving oral glucocorticoids with the resolution of inflammation based on bronchoalveolar lavage fluid (BALF) cytology. Ten cats diagnosed with lower airway disease based on characteristic clinical signs and inflammatory BALF cytology received oral glucocorticoids for at least 3 weeks. They were required to have resolution of clinical signs and BALF collected while asymptomatic and still receiving glucocorticoids. Cats received prednisolone or prednisone (average dose of 1.8±0.2mg/kg daily) for 35.7±5.5 days. Three cats had resolution of clinical signs and lacked inflammatory BALF cytology; seven had persistent inflammatory BALF cytology despite resolution of clinical signs. Given that subclinical inflammation during high-dose glucocorticoid treatment was common, current recommendations to taper therapy based on resolution of clinical signs should be re-evaluated.

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“…Correlation between the severity of radiographic findings and the severity or reversibility of an asthma attack is generally poor, [68][69][70] and radiographs provide significant information that alters treatment in 5% or fewer patients with acute asthma. 68,70,72 The ACR considers chest radiography warranted in adult patients with asthma when a clinical suspicion for pneumonia or pneumothorax is present, or unless one or more of the following is noted: chest pain, edema, leukocytosis, or the patient has a history of either coronary artery disease or congestive heart failure. 68,70,72 The ACR considers chest radiography warranted in adult patients with asthma when a clinical suspicion for pneumonia or pneumothorax is present, or unless one or more of the following is noted: chest pain, edema, leukocytosis, or the patient has a history of either coronary artery disease or congestive heart failure.…”

Section: Acute Asthmamentioning

confidence: 99%