“…Furthermore, the high importance of medical images in diagnostic and therapy, new and improved imaging modalities as well as the high complexity and enormous increase of medical image data in clinical routine has reinforced the need for the development of efficient and optimized medical image computing methods. Hence, medical image computing has been established as a highly innovative field in medical informatics [1][2][3][4][5][6]. Although many medical image computing methods and systems are yet applied in practice, their grade of automation, accuracy, reproducibility and robustness has to be increased to meet the requirements in clinical routine.…”