Medical History, Lifestyle, Family History, and Occupational Risk Factors for Adult Acute Lymphocytic Leukemia: The InterLymph Non-Hodgkin Lymphoma Subtypes Project

Skibola, Christine F.; Slager, Susan L.; Berndt, Sonja I.; Lightfoot, Tracy; Sampson, Joshua N.; Morton, Lindsay M.; Weisenburger, Dennis D.

doi:10.1093/jncimonographs/lgu009

Cited by 16 publications

(13 citation statements)

References 27 publications

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“…Findings from this project, as described in subsequent articles in this issue (78)(79)(80)(81)(82)(83)(84)(85)(86)(87)(88)(89), accomplish two of the primary goals of the consortium: investigation of the etiology of specific NHL subtypes and comparison of risk factors, including those of rare prevalence, among NHL • Data were collected and analyzed separately by beverage type (e.g., beer, wine, and liquor) and then summed to evaluate total alcohol consumption (15 studies), or collected only for any alcohol consumption (two studies).…”

Section: Discussionmentioning

confidence: 91%

“…The InterLymph NHL Subtypes Project demonstrates the benefits of long-term and large-scale international collaboration for advancing etiologic research. Results from the project identify important associations with specific NHL subtypes for some risk factors and shared among multiple NHL subtypes for others (78)(79)(80)(81)(82)(83)(84)(85)(86)(87)(88)(89). Findings also suggest possible mechanisms of lymphomagenesis and provide clues for prevention with modifiable risk factors.…”

Section: Occupationmentioning

confidence: 92%

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Rationale and Design of the International Lymphoma Epidemiology Consortium (InterLymph) Non-Hodgkin Lymphoma Subtypes Project

et al. 2014

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BackgroundNon-Hodgkin lymphoma (NHL), the most common hematologic malignancy, consists of numerous subtypes. The etiology of NHL is incompletely understood, and increasing evidence suggests that risk factors may vary by NHL subtype. However, small numbers of cases have made investigation of subtype-specific risks challenging. The International Lymphoma Epidemiology Consortium therefore undertook the NHL Subtypes Project, an international collaborative effort to investigate the etiologies of NHL subtypes. This article describes in detail the project rationale and design.

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Section: Discussionmentioning

confidence: 91%

Section: Occupationmentioning

confidence: 92%

Rationale and Design of the International Lymphoma Epidemiology Consortium (InterLymph) Non-Hodgkin Lymphoma Subtypes Project

et al. 2014

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“…Down syndrome is a strong risk factor for acute lymphocytic leukemia, and other genetic disorders are associated with this cancer as well. In addition to genetic susceptibility, high birth weight and childhood immune response may contribute to the risk of acute lymphocytic leukemia . Genetic susceptibility may also play a role in adult acute lymphocytic leukemia, but other nongenetic factors have been suggested for adult acute lymphocytic leukemia as well, such as obesity and occupational exposures like working in the leather or textile industries …”

Section: Selected Findingsmentioning

confidence: 99%

2016 US lymphoid malignancy statistics by World Health Organization subtypes

Teras

DeSantis

Cerhan

et al. 2016

CA A Cancer J Clinicians

868

610

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Collectively, lymphoid neoplasms are the fourth most common cancer and the sixth leading cause of cancer death in the United States. The authors provide contemporary lymphoid neoplasm statistics by subtype based on the 2008 World Health Organization classifications, including the most current US incidence and survival data. Presented for the first time are estimates of the total numbers of US lymphoid neoplasm cases by subtype as well as a detailed evaluation of incidence and survival statistics. In 2016, 136,960 new lymphoid neoplasms are expected. Overall lymphoma incidence rates have declined in recent years, but trends vary by subtype. Precursor lymphoid neoplasm incidence rates increased from 2001 to 2012, particularly for B-cell neoplasms. Among the mature lymphoid neoplasms, the fastest increase was for plasma cell neoplasms. Rates also increased for mantle cell lymphoma (males), marginal zone lymphoma, hairy cell leukemia, and mycosis fungoides. Like incidence, survival for both mature T-cell lymphomas and mature B-cell lymphomas varied by subtype and by race. Patients with peripheral T-cell lymphomas had among the worst 5-year relative survival (36%-56%, depending on race/sex), while those with mycosis fungoides had among the best survival (79%-92%). For B-cell lymphomas, 5-year survival ranged from 83% to 91% for patients with marginal zone lymphoma and from 78% to 92% for those with hairy cell leukemia; but the rates were as low as 47% to 63% for patients with Burkitt lymphoma and 44% to 48% for those with plasma cell neoplasms. In general, black men had the lowest survival across lymphoid malignancy subtypes. These contemporary incidence and survival statistics are useful for developing management strategies for these cancers and can offer clues regarding their etiology. CA Cancer J Clin 2016. © 2016 American Cancer Society.

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“…Ripert et al [73] reported that a history of solid tumors in first or second degree relatives was associated with a significant increased risk of childhood B-ALL and a history of hematopoietic neoplasms in such relatives was associated with a significant risk of AML. Shibola et al [74] reported an increased risk for adult B-ALL in families with a history of hematologic malignancy. Zierhut et al [75] found no such associations.…”

Section: B-cell Acute Lymphocyticmentioning

confidence: 99%

Familial Leukemias

Wiernik

2015

Curr. Treat. Options in Oncol.

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Familial leukemia has been described for more than 50 years but only recently have modern genetic techniques allowed for the investigation of the genome. Genome-wide association studies have identified a number of genetic sites that appear to relate to susceptibility to leukemia in certain families and occasionally to susceptibility to a specific leukemia in general. Many questions remain, including susceptibility to what? An oncogenic virus? An environmental chemical? Mutation of another gene induced by a heritable mutation-promoting gene?.Clinically important facts have been learned. Chronic lymphocytic leukemia (CLL) is by far the most common familial leukemia. Patients with CLL have approximately a 10% chance of a first-degree relative developing CLL, and even a greater chance of one developing monoclonal B-cell lymphocytosis which may be an asymptomatic forme fruste of the neoplasm. Furthermore, there may be an increased incidence of breast cancer in familial CLL pedigrees which raises the question of a common etiology for neoplasms in general, or at least a previously unrecognized relationship among them.

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Medical History, Lifestyle, Family History, and Occupational Risk Factors for Adult Acute Lymphocytic Leukemia: The InterLymph Non-Hodgkin Lymphoma Subtypes Project

Cited by 16 publications

References 27 publications

Rationale and Design of the International Lymphoma Epidemiology Consortium (InterLymph) Non-Hodgkin Lymphoma Subtypes Project

Rationale and Design of the International Lymphoma Epidemiology Consortium (InterLymph) Non-Hodgkin Lymphoma Subtypes Project

2016 US lymphoid malignancy statistics by World Health Organization subtypes

Familial Leukemias

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