Medical-Grade Honey Enhances the Healing of Caesarean Section Wounds and Is Similarly Effective to Antibiotics Combined with Povidone-Iodine in the Prevention of Infections—A Prospective Cohort Study

Bocoum, Amadou; Riel, Senna J J M van; Traoré, S; Oum, Elisabeth Florine Ngo; Traoré, Youssouf; Thera, Augustin Tioukani; Seydou, Fané; Dembélé, B T; Cremers, Niels A. J.

doi:10.3390/antibiotics12010092

Cited by 7 publications

(14 citation statements)

References 60 publications

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“…Statistical analysis was performed in SPSS Statistics v. 26, IBM. As no previous known data involving the effect of MGH on suture material were available to perform a power calculation, the sample size of 10 strands was determined based on similar studies investigating medias effect on suture material, 13,19 and on the guidelines from the USP pharmacopenia 23 stating that at least ten strands should be used to test the tensile properties of a synthetic absorbable suture material. 23 Prior to analysis, homogeneity of variances in the data was checked using a Levene test.…”

Section: Discussionmentioning

confidence: 99%

“…In human studies, MGH decreases the healing time and improves the aesthetic result of surgical incisions when used topically in the post‐operative phase 12,13 . In two recent equine studies, MGH was applied subcutaneously after traumatic wound reconstruction and in abdominal wounds in horses undergoing colic surgery 5,6 .…”

Section: Introductionmentioning

confidence: 99%

“…10,11 In human studies, MGH decreases the healing time and improves the aesthetic result of surgical incisions when used topically in the post-operative phase. 12,13 In two recent equine studies, MGH was applied subcutaneously after traumatic wound reconstruction and in abdominal wounds in horses undergoing colic surgery. 5,6 These studies showed a significant protective effect of a single subcutaneous application of MGH against wound and surgical site infections in horses.…”

Section: Introductionmentioning

confidence: 99%

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The effect of medical grade honey on tensile strength, strain, and Young's modulus of synthetic absorbable suture material used in equine surgery

Madsen,

Martens,

Haspeslagh

et al. 2023

Equine Veterinary Journal

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BackgroundMedical grade honey (MGH) has been introduced as a protective measure against surgical site infections in equine surgery, but the effect on suture material has not been investigated.ObjectiveTo evaluate the effect of MGH on the tensile properties of three synthetic absorbable suture materials.Study DesignIn vitro experiments.MethodsTen strands of Polydioxanone USP 2 (PD2), Polyglactin 910 USP 2 (PG2) and Polyglecaprone USP 2‐0 (PC2‐0) were incubated 1, 7, 14, 21 and 28 days in MGH, phosphate‐buffered saline (PBS), equine plasma (EP) and MGH mixed with equine plasma (HP). Mechanical testing was performed recording maximum load at failure (N), strain at failure and Young's modulus (N/mm2). The results were reported from a Welch or regular ANOVA.ResultsPD2 in MGH had a significantly higher tensile strength compared to PD2 in EP (p < 0.05, mean difference (md) = 16.95 N, CI95% (9.19–24.70 N)) and PBS (p < 0.05, md = 14.48 N CI95% (6.73–22.23 N)) on day 7 and the remaining time points. PG2 incubated in MGH had a significantly higher tensile strength compared to EP (p < 0.05, md = 69.28 N CI95% (64.16–74.40 N)) and PBS (p < 0.05, md = 56.90 N CI95% (51.78–62.02 N)) until day 28. PC2‐0 incubated in MGH had a significantly higher tensile strength compared to EP (p < 0.05 md = 12.40 N CI95% (4.59 N–20.20 N)) and PBS (p < 0.05 md = 11.23 CI95% (3.42–19.03 N)) on day 7 and the remaining time points.Main LimitationsThe sutures were unloaded during incubation and a single cycle to failure test was only performed, which does not reflect the in vivo environment where shear forces are present.ConclusionsMGH did not negatively affect the tensile strength of the suture material and can safely be applied in contact with suture materials commonly used in equine surgery.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The effect of medical grade honey on tensile strength, strain, and Young's modulus of synthetic absorbable suture material used in equine surgery

Madsen,

Martens,

Haspeslagh

et al. 2023

Equine Veterinary Journal

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“…Several publications have highlighted the effective use of supplemented MGH-based dressings for surgical wounds (41,42,(65)(66)(67)(68)(69). Although most publications include infected, dehisced surgical wounds, MGH can also be used to reduce the infection rate and improve healing as shown by various clinical studies (69)(70)(71). Based on the SSI classification, one could use an MGHbased foam dressing alone or combined with an MGHbased wound gel or ointment (Figure 1).…”

Section: Surgical Site Managementmentioning

confidence: 99%

Medical-Grade Honey Is a Versatile Wound Care Product for the Elderly

Chrysostomou,

Pokorná,

Cremers

et al. 2024

J Aging Res & Lifestyle

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INTRODUCTION: Ageing of the global population has led to an increase in the demand for the treatment of wounds, especially considering the challenges of managing wounds in the elderly. Therefore, more effective treatment strategies need to be explored. In this article, we aimed to compare medicalgrade honey (MGH) products with other wound care products and to provide guidelines on using MGH in wounds commonly found in the elderly. METHODS: Based on literature research and expert opinion, an overview of commonly used wound care products and their wound healing characteristics is provided. In addition, literature-based classification of wounds in the elderly and the recommendations for treatments are provided. RESULTS: Frequently used wound care products include povidone-iodine, enzymatic products, absorbing dressings, larvae, silver dressings, and MGH dressings. Supported by systematic reviews and meta-analyses, MGH dressings were identified as the most potent and all-round wound care product compared to the others. Next, we provided basic guidelines for managing the most common wounds in the elderly, both acute and chronic, and specified how and which MGH products can be used in these wounds. CONCLUSION: MGH is a widely applicable, safe, easy-to-use, and cost-effective product to manage wounds in the elderly. In case of doubt, refer to a trained wound care specialist who can support the treatment of difficult-to-heal wounds.

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“…MGH may treat and prevent infections by modulating immune cell activities and cytokine production, either directly or indirectly, through its antimicrobial activity that affects bacterial colonization and thus prevents a subsequent immune response to these pathogens [28,123]. MGH does also prevent infections, and its prophylactic activity has been demonstrated previously in different settings (e.g., lacerations, colic surgery, caesarean section, and heel pressure ulcers) [124][125][126][127].…”

Section: Mgh Exerts Anti-inflammatory Anti-oxidant and Immunomodulato...mentioning

confidence: 99%

Medical-Grade Honey as a Potential New Therapy for Bacterial Vaginosis

Lardenoije,

van Riel,

Peters

et al. 2024

Antibiotics

Self Cite

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The prevalence of bacterial vaginosis (BV) among women of reproductive age is 29%. BV arises from a vaginal imbalance marked by reduced levels of lactic acid-producing lactobacilli and an overgrowth of pathogenic anaerobes. The multifactorial nature of BV’s pathogenesis complicates its treatment. Current antibiotic therapy exhibits a recurrence rate of about 60% within a year. Recurrence can be caused by antibiotic treatment failure (e.g., due to antimicrobial resistance), the persistence of residual infections (e.g., due to biofilm formation), and re-infection. Because of the high recurrence rates, alternative therapies are required. Medical-grade honey (MGH), known for its antimicrobial and wound healing properties in wound care, emerges as a potential novel therapy for BV. MGH exerts broad-spectrum antimicrobial activity, employing multiple mechanisms to eliminate the risk of resistance. For example, the low pH of MGH and the production of hydrogen peroxide benefit the microbiota and helps restore the natural vaginal balance. This is supported by in vitro studies demonstrating that MGH has an antibacterial effect on several pathogenic bacteria involved in the pathophysiology of BV, while lactobacilli and the vaginal microenvironment can be positively affected. In contrast to antibiotics, MGH exerts anti-biofilm activity, affects the microbiome as pre- and probiotic, and modulates the vaginal microenvironment through its anti-inflammatory, anti-oxidative, physicochemical, and immunomodulatory properties. More clinical research is required to confirm the positive effect of MGH on BV and to investigate the long-term cure rate.

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Medical-Grade Honey Enhances the Healing of Caesarean Section Wounds and Is Similarly Effective to Antibiotics Combined with Povidone-Iodine in the Prevention of Infections—A Prospective Cohort Study

Cited by 7 publications

References 60 publications

The effect of medical grade honey on tensile strength, strain, and Young's modulus of synthetic absorbable suture material used in equine surgery

The effect of medical grade honey on tensile strength, strain, and Young's modulus of synthetic absorbable suture material used in equine surgery

Medical-Grade Honey Is a Versatile Wound Care Product for the Elderly

Medical-Grade Honey as a Potential New Therapy for Bacterial Vaginosis

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