Medical‐Grade Fluid Silicone: A Monographic Review

Selmanowitz, Victor J.; Orentreich, Norman

doi:10.1111/j.1524-4725.1977.tb00366.x

Cited by 102 publications

(67 citation statements)

References 41 publications

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“…9 In recent years, implant materials have also been found to migrate to the lung and the brain. 10 It is therefore advantageous to use degradable materials. The ideal filling substance for soft-tissue augmentation should be biocompatible, nonantigenic, nonpyrogenic, noninflammatory, nontoxic, easy to use, stable after injection, nonmigratory, long lasting but reabsorbable, natural looking and not too expensive.…”

Section: Discussionmentioning

confidence: 99%

Effects of glans penis augmentation using hyaluronic acid gel for premature ejaculation

et al. 2004

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The main limitation of medical treatment for premature ejaculation is recurrence after withdrawal of medication. We evaluated the effect of glans penis augmentation using injectable hyaluronic acid (HA) gel for the treatment of premature ejaculation via blocking accessibility of tactile stimuli to nerve receptors. In 139 patients of premature ejaculation, dorsal neurectomy (Group I, n ¼ 25), dorsal neurectomy with glandular augmentation (Group II, n ¼ 49) and glandular augmentation (Group III, n ¼ 65) were carried out, respectively. Two branches of dorsal nerve preserving that of midline were cut at 2 cm proximal to coronal sulcus. For glandular augmentation, 2 cc of HA was injected into the glans penis, subcutaneously. At 6 months after each procedure, changes of glandular circumference were measured by tapeline in Groups II and III. In each groups, ejaculation time, patient's satisfaction and partner's satisfaction were also assessed. There was no significant difference in preoperative ejaculation time among three groups. Preoperative ejaculation times were 89.2740.29, 101.54759.42 and 96.5752.32 s in Groups I, II and III, respectively. Postoperative ejaculation times were significantly increased to 235.6758.6, 324.247107.58 and 281.9793.2 s in Groups I, II and III, respectively (Po0.01). The percentage of postoperative satisfaction in both patient and his partner was 68% (17/25) and 44% (7/16) in Group I, 80% (39/49) and 66% (25/38) in Group II and 75% (49/65) and 62% (32/52) in Group III, respectively. Maximal glandular girth was significantly increased from 9.1670.59 to 10.9570.4 cm in Group II and 8.9570.54 to 11.6770.71 cm in Group III, respectively. These results suggest that glandular augmentation with injectable HA gel is a safe and effective modality to reduce sensory of glans penis. Long-term follow-up for residual volume and efficacy should be requested to establish its precise therapeutic potentials in premature ejaculation.

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Section: Discussionmentioning

confidence: 99%

Effects of glans penis augmentation using hyaluronic acid gel for premature ejaculation

et al. 2004

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show abstract

“…7 In recent years, implant materials have also been found to migrate to the lung and the brain. 8 It is therefore advantageous to use degradable materials. The ideal filling substance for soft-tissue augmentation should be biocompatible, nonantigenic, nonpyrogenic, noninflammatory, nontoxic, easy to use, stable after injection, nonmigratory, long-lasting but reabsorbable, natural looking, and not too expensive.…”

Section: Discussionmentioning

confidence: 99%

Human glans penis augmentation using injectable hyaluronic acid gel

et al. 2003

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Although augmentation phalloplasty is not an established procedure, some patients still need enlargement of their penis. Current penile augmentation is girth enhancement of penile body by dermofat graft. We performed this study to identify the efficacy and the patient's satisfaction of human glans penis augmentation with injectable hyaluronic acid gel. In 100 patients of subjective small penis (Group I) and 87 patients of small glans after dermofat graft (Group II), 2 cm 3 of hyaluronic acid gel was injected into the glans penis, subcutaneously. At 1 y after injection, changes of glandular diameter were measured by tapeline. Patient's visual estimation of glandular size (Gr 0-4) and patient's satisfaction (Grade (Gr) 0-4) were evaluated, respectively. Any adverse reactions were also evaluated. The mean age of patients was 42.2 (30-70) y in Group I and 42.13 (28-61) y in Group II. The maximal glandular circumference was significantly increased compared to basal circumference of 9.13 7 0.64 cm in Group I (Po0.01) and 9.49 7 1.05 cm in Group II (Po0.01) at 1 y after injection. Net increase of maximal glandular circumference after glans augmentation was 14.93 7 0.80 mm in Group I and 14.78 7 0.89 mm in Group II. In patient's visual estimation, more than 50% of injected volume was maintained in 95% of Group 1 and 100% of Group II. The percentage of postoperative satisfaction (Gr 4, 5) was 77% in Group 1 and 69% in Group II. There was no abnormal reaction in area feeling, texture, and color. In most cases, initial discoloration by glandular swelling recovered to normal within 2 weeks. There were no signs of inflammation and no serious adverse reactions in all cases. These results suggest that injectable hyaluronic acid gel is a safe and effective material for augmentation of glans penis.

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“…Nodules are caused by excessive amounts of product injected or when injected too superficially. Localizations with very thin skin, such as periorbital area, are much more affected by the development of underlying nodules [10,68]. Skin texture alterations are reported due to an exaggerated proliferative fibrohistolytic response [10].…”

Section: Adverse Events Related To Permanent Fillersmentioning

confidence: 99%

“…Temporary mild bruising, edema, dyschromia, swelling, pain, erythema, and bleeding may occur during or right after injection. In some cases, postinflammatory hyperpigmentation occurs [68]. Overcorrection is a technique-dependent complication that results in small nodular elevation shortly after injection.…”

Section: Adverse Events Related To Permanent Fillersmentioning

confidence: 99%

Critical Appraisal of the Safety of Dermal Fillers: A Primer for Clinicians

Luebberding

Alexiades-Armenakas

2013

Curr Derm Rep

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Injectable cosmetic wrinkle fillers are soft-tissue fillers approved as medical devices by the U.S. Food and Drug Administration (FDA). These devices are injected into the skin for correcting soft-tissue contour defects, such as moderate and severe wrinkles and folds, and for restoring the signs of facial fat loss in people with human immunodeficiency virus. Although the aesthetic treatment with injectable dermal fillers is considered to be safe, adverse events are involved with this minimally-invasive treatment. The FDA received 930 post-marked reports of adverse event from 2003 through 2008, of which 823 were deemed severe and 638 required medical treatment and follow-up.

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Medical‐Grade Fluid Silicone: A Monographic Review

Cited by 102 publications

References 41 publications

Effects of glans penis augmentation using hyaluronic acid gel for premature ejaculation

Effects of glans penis augmentation using hyaluronic acid gel for premature ejaculation

Human glans penis augmentation using injectable hyaluronic acid gel

Critical Appraisal of the Safety of Dermal Fillers: A Primer for Clinicians

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