Medical gas plasma augments bladder cancer cell toxicity in preclinical models and patient-derived tumor tissues

Gelbrich, Nadine; Miebach, Lea; Berner, Julia; Freund, Eric; Saadati, Fariba; Schmidt, Anke; Stope, Matthias B.; Zimmermann, Uwe; Burchardt, Martin; Bekeschus, Sander

doi:10.1016/j.jare.2022.07.012

Cited by 10 publications

(9 citation statements)

References 85 publications

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“…Thirdly, CAP acts post-surgery, eliminating pathogens, boosting clotting, and aiding tissue recovery [ 58 ]. Notably, it kills residual cancer cells, curbing metastasis risk [ 55 , [58] , [59] , [60] , [61] ]. Mettelman et al highlighted CAP's benefits for HNSCC patients, including reduced pain, improved healing, and social well-being [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

Cold atmospheric plasma sensitizes head and neck cancer to chemotherapy and immune checkpoint blockade therapy

Wang,

Mang,

et al. 2024

Redox Biology

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Section: Discussionmentioning

confidence: 99%

Cold atmospheric plasma sensitizes head and neck cancer to chemotherapy and immune checkpoint blockade therapy

Wang,

Mang,

et al. 2024

Redox Biology

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“…Low-power plasma can stop the proliferation and progression of cancer cells, and higher power can even lead to their death. The general anticancer mechanism of NTP is based on the activities of reactive oxygen and nitrogen species [ 70 , 71 ]. Many reactive species among those appearing in NTP are toxic to cancer cells according to the same mechanisms indicated in Table 1 .…”

Section: Anti-cancer Therapiesmentioning

confidence: 99%

Non-Thermal Plasma Application in Medicine—Focus on Reactive Species Involvement

Moszczyńska

Roszek

Wiśniewski

2023

IJMS

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Non-thermal plasma (NTP) application in medicine is a dynamically developing interdisciplinary field. Despite the fact that basics of the plasma phenomenon have been known since the 19th century, growing scientific attention has been paid in recent years to the use of plasma in medicine. Three most important plasma-based effects are pivotal for medical applications: (i) inactivation of a broad spectrum of microorganisms, (ii) stimulation of cell proliferation and angiogenesis with lower plasma treatment intensity, and (iii) inactivation of cells by initialization of cell death with higher plasma intensity. In this review, we explain the underlying chemical processes and reactive species involvement during NTP in human (or animal) tissues, as well as in bacteria inactivation, which leads to sterilization and indirectly supports wound healing. In addition, plasma-mediated modifications of medical surfaces, such as surgical instruments or implants, are described. This review focuses on the existing knowledge on NTP-based in vitro and in vivo studies and highlights potential opportunities for the development of novel therapeutic methods. A full understanding of the NTP mechanisms of action is urgently needed for the further development of modern plasma-based medicine.

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“…Although commercially available organoid models are limited, they have been used in several studies as 3D experimental models to examine the anticancer efficacy of CAP. For instance, CAP demonstrated selective toxicity against bladder cancer cells in patient-derived preclinical organoid models ( Gelbrich et al ., 2023 ) and reduced the spheroid area and halted epithelial-mesenchymal transition (EMT) in patient-derived TNBC and bladder cancer organoids ( Wang et al ., 2021 ). Additionally, cytotoxicity, spheroid shrinkage and cell migration were monitored using 3D glioblastoma spheroid tumours after CAP treatment, where the impact of short-lived species was emphasized ( Privat-Maldonado et al ., 2018 ).…”

Section: Current Status Of Cap As An Oncotherapymentioning

confidence: 99%

Current Status and Future Trends of Cold Atmospheric Plasma as an Oncotherapy

Dai,

Wu,

et al. 2023

Biomol Ther (Seoul)

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Cold atmospheric plasma (CAP), a redox modulation tool, is capable of inhibiting a wide spectrum of cancers and has thus been proposed as an emerging onco-therapy. However, with incremental successes consecutively reported on the anticancer efficacy of CAP, no consensus has been made on the types of tumours sensitive to CAP due to the different intrinsic characteristics of the cells and the heterogeneous design of CAP devices and their parameter configurations. These factors have substantially hindered the clinical use of CAP as an oncotherapy. It is thus imperative to clarify the tumour types responsive to CAP, the experimental models available for CAP-associated investigations, CAP administration strategies and the mechanisms by which CAP exerts its anticancer effects with the aim of identifying important yet less studied areas to accelerate the process of translating CAP into clinical use and fostering the field of plasma oncology.

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Medical gas plasma augments bladder cancer cell toxicity in preclinical models and patient-derived tumor tissues

Cited by 10 publications

References 85 publications

Cold atmospheric plasma sensitizes head and neck cancer to chemotherapy and immune checkpoint blockade therapy

Cold atmospheric plasma sensitizes head and neck cancer to chemotherapy and immune checkpoint blockade therapy

Non-Thermal Plasma Application in Medicine—Focus on Reactive Species Involvement

Current Status and Future Trends of Cold Atmospheric Plasma as an Oncotherapy

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