Medical evaluation of subjects with known body levels of 2,3,7,8,— tetrachlorodibenzo‐p‐dioxin

Kb, Webb; Evans, RG; Ap, Knutsen; Roodman, S. T.; Roberts, D. W.; Wf, Schramm; Gibson, BB; Andrews, Jr Js; Ll, Needham; Patterson, Donald

doi:10.1080/15287398909531339

Cited by 50 publications

(40 citation statements)

References 18 publications

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“…Changes in cell surface markers on T cells represent an apparently sensitive biomarker response to the effects of dioxin-like compounds in rodents and primates. Dioxin-like compounds can affect the primary immune response by changing the CD4/CD8 ratio or the ratio of other lymphocyte subpopulations (11,15,19,(38)(39)(40)(41). In the present study we found no associations between T-helper or Tsuppressor cells and the serum PCB/CALUX TEQ levels.…”

Section: Discussioncontrasting

confidence: 49%

Immunologic biomarkers in relation to exposure markers of PCBs and dioxins in Flemish adolescents (Belgium).

Heuvel

Koppen

Staessen

et al. 2002

Environ Health Perspect

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In this study, we investigated 17- to 18-year-old boys and girls to determine whether changes in humoral or cellular immunity or respiratory complaints were related to blood serum levels of polychlorinated biphenyls (PCBs) and dioxin-like compounds after lifetime exposure in Flanders (Belgium). We obtained blood samples from and administered questionnaires to 200 adolescents recruited from a rural area and two urban suburbs. Physicians recorded medical history and respiratory diseases. We measured immunologic biomarkers such as differential blood cell counts, lymphocyte phenotypes, and serum immunoglobulins. As biomarkers of exposure, we determined the serum concentrations of PCBs (PCB 138, PCB 153, and PCB 180) and dioxin-like compounds [chemical-activated luciferase expression (CALUX) bioassay]. The percentages of eosinophils and natural killer cells in blood were negatively correlated with CALUX toxic equivalents (TEQs) in serum (p = 0.009 and p = 0.05, respectively). Increased serum CALUX TEQs resulted in an increase in serum IgA levels (p = 0.05). Furthermore, levels of specific IgEs (measured by radioallergosorbent tests) of cat dander, house dust mite, and grass pollen were also significantly and negatively associated with the CALUX TEQ, with odds ratios (ORs) equal to 0.63 [95% confidence interval (CI), 0.42-0.96], 0.68 (0.5-0.93), and 0.70 (0.52-0.95), respectively. In addition, reported allergies of the upper airways and past use of antiallergic drugs were negatively associated with CALUX TEQs, with ORs equal to 0.66 (0.47-0.93) and 0.58 (0.39-0.85), respectively. We found a negative association between IgGs and marker PCBs in serum (p = 0.009). This study shows that immunologic measurements and respiratory complaints in adolescents were associated with environmental exposure to polyhalogenated aromatic hydrocarbons (PHAHs). The negative correlation between PHAHs and allergic responses in adolescents suggested that exposure may entail alterations in the immune status.

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Section: Discussioncontrasting

confidence: 49%

Immunologic biomarkers in relation to exposure markers of PCBs and dioxins in Flemish adolescents (Belgium).

Heuvel

Koppen

Staessen

et al. 2002

Environ Health Perspect

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“…Other reports showed no alterations in immunoglobulin levels (Hoffman et al 1986;Jennings et al 1988;Jung et al 1998;Marth et al 1995;Michalek et al 1999;Nagayama et al 2001). A slight positive increase in IgG levels was found in two studies Webb et al 1989). However, these studies did not exclude subjects with concurrent medical conditions likely to increase circulating IgG levels (Ravel 1995).…”

Section: Discussionmentioning

confidence: 96%

“…One article reported total γ-globulin levels (Jansing and Korff 1994). Four studies described a decrease in immunoglobulin levels (Halperin et al 1998;Jansing and Korff 1994;Løvik et al 1996;Neubert et al 2000), and two studies reported increased IgG Webb et al 1989). Complement levels were determined in three studies, and only one of them included both C3 and C4 ).…”

Section: Resultsmentioning

confidence: 99%

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Immunologic effects of dioxin: new results from Seveso and comparison with other studies.

Baccarelli

Mocarelli

Patterson

et al. 2002

Environ Health Perspect

119

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Animal studies indicate that the immune system is one of the most sensitive targets of the toxic effects of 2,3,7,8-tetrachloro-p-dibenzodioxin (TCDD). TCDD inhibits immunoglobulin secretion and decreases resistance to bacterial, viral, and parasitic infections in exposed animals. Nearly 20 years after the Seveso, Italy, accident, we measured immunoglobulin and complement plasma levels in a random sample of the population in the most highly exposed zones (n = 62) and in the surrounding noncontaminated area (n = 58). Plasma IgG levels decreased with increasing TCDD plasma concentration (r = -0.35, p = 0.0002). Median IgG concentration decreased from 1,526 mg/dL in the group with the lowest (< 3.5 ppt) TCDD levels to 1,163 mg/dL in the group with the highest (20.1-89.9 ppt) TCDD levels (p = 0.002). The association was significant (p = 0.0004) after adjusting for age, sex, smoking, and consumption of domestic livestock and poultry in multiple regression analysis and persisted after exclusion of subjects with inflammatory diseases and those using antibiotics or nonsteroidal anti-inflammatory drugs. IgM, IgA, C3, and C4 plasma concentrations did not exhibit any consistent association with TCDD levels. We performed a systematic review of all the articles published between 1966 and 2001 on human subjects exposed to TCDD reporting information on circulating levels of immunoglobulins and/or complement components. The literature indicates that the evidence for effects of TCDD on humoral immunity is sparse. Methodologic issues, results, and possible sources of variation between studies are discussed. The possible long-term immunologic effects of TCDD exhibited by the participants of the present study, coupled with the increased incidence of lymphatic tumors in the area of the accident, warrant further investigation.

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“…Studies on community residents of Quail Run Mobile Home Park (Missouri residents, USA), environmentally exposed to contaminated industrial sludge, showed a significantly decreased percentage of lymphocytes expressing CD3þ, CD4þ, and CD2þ, but the mean numbers of each of the T-cell subsets was comparable between the groups (Hoffman et al 1986;Knutsen et al 1987). Subsequent studies (Evans et al 1988;Webb et al 1989) showed significant increases associated with higher concentrations of TCDD for IgG, %CD3þ, %CD8þ, number of T-cells, percentages of CD2þ, and CD4þ/Leu-8 position. Svensson et al (1994) indicated that high consumption of fatty fish from the Baltic Sea, contaminated with persistent organochlorine compounds, is associated with lower number of natural killer cells.…”

Section: 14mentioning

confidence: 99%

A review of the role of lymphoma markers and occupational and environmental exposures

Hosnijeh

Heederik

Vermeulen

2012

Veterinary Quarterly

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Medical evaluation of subjects with known body levels of 2,3,7,8,— tetrachlorodibenzo‐p‐dioxin

Abstract: Forty-one persons with a history of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure and measured adipose tissue TCDD levels were evaluated for potential health effects. No pattern of clinical abnormalities emerged related to TCDD levels.

Cited by 50 publications

References 18 publications

Immunologic biomarkers in relation to exposure markers of PCBs and dioxins in Flemish adolescents (Belgium).

Immunologic biomarkers in relation to exposure markers of PCBs and dioxins in Flemish adolescents (Belgium).

Immunologic effects of dioxin: new results from Seveso and comparison with other studies.

A review of the role of lymphoma markers and occupational and environmental exposures

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