“… 21 CDSS for mechanical ventilation take several forms, from standalone systems to an adjunct to the electronic health record, or a webpage that requires data input, with some ventilators also having built-in CDSS. They can support a variety of decisions, including titrating ventilator settings, 17 supporting the implementation of lung-protective ventilation, 18 assisting with weaning from mechanical ventilation, 19 and those that support decisions in several areas. 20 CDSS may optimise ventilator settings without clinician input (closed-loop), 22 , 23 or may be used at the point of care, allowing clinicians to combine their knowledge with the suggestions provided by the CDSS (open-loop).…”