Medical Applications of Magnetic Nanoparticles

Binns, C.

doi:10.1016/b978-0-08-098353-0.00006-3

Cited by 21 publications

(8 citation statements)

References 76 publications

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“…Control of nanoparticle size, shape, and crystallinity of superparamagnetic materials (i.e., Fe 3 O 4 , γ-Fe 2 O 3 , and MFe 2 O 4 where M = Ni, Mn, or Co [13]) can be manipulated to enhance their magnetic properties and their RF magnetic heating performance making them more suitable for magnetic hyperthermia applications -a promising cancer treatment therapy with encouraging findings for breast carcinoma and brain tumors [14]. However, reasonable concerns surround the toxicity and bioaccumulation of iron oxide nanoparticles within the human body [14,15].…”

Section: Introductionmentioning

confidence: 99%

Nano-structural effects on Hematite (α-Fe2O3) nanoparticle radiofrequency heating

et al. 2021

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Nano-sized hematite (α-Fe2O3) is not well suited for magnetic heating via an alternating magnetic field (AMF) because it is not superparamagnetic—at its best, it is weakly ferromagnetic. However, manipulating the magnetic properties of nano-sized hematite (i.e., magnetic saturation (Ms), magnetic remanence (Mr), and coercivity (Hc)) can make them useful for nanomedicine (i.e., magnetic hyperthermia) and nanoelectronics (i.e., data storage). Herein we study the effects of size, shape, and crystallinity on hematite nanoparticles to experimentally determine the most crucial variable leading to enhancing the radio frequency (RF) heating properties. We present the synthesis, characterization, and magnetic behavior to determine the structure–property relationship between hematite nano-magnetism and RF heating. Increasing particle shape anisotropy had the largest effect on the specific adsorption rate (SAR) producing SAR values more than 6 × greater than the nanospheres (i.e., 45.6 ± 3 W/g of α-Fe2O3 nanorods vs. 6.89 W/g of α-Fe2O3 nanospheres), indicating α-Fe2O3 nanorods can be useful for magnetic hyperthermia.

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Section: Introductionmentioning

confidence: 99%

Nano-structural effects on Hematite (α-Fe2O3) nanoparticle radiofrequency heating

et al. 2021

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“…Here, ε b is the dielectric constant for the medium (dimensionless), ε 0 is permittivity of the vacuum (dimensionless), and ξ , the zeta potential (mV), is the electrokinetic potential at the outer surface of the electric double layer (Binns, 2014). As seen in the difference between Eqs.…”

Section: A Electrophoresismentioning

confidence: 99%

Shape-based separation of micro-/nanoparticles in liquid phases

et al. 2018

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The production of particles with shape-specific properties is reliant upon the separation of micro-/nanoparticles of particular shapes from particle mixtures of similar volumes. However, compared to a large number of size-based particle separation methods, shape-based separation methods have not been adequately explored. We review various up-to-date approaches to shape-based separation of rigid micro-/ nanoparticles in liquid phases including size exclusion chromatography, field flow fractionation, deterministic lateral displacement, inertial focusing, electrophoresis, magnetophoresis, self-assembly precipitation, and centrifugation. We discuss separation mechanisms by classifying them as either changes in surface interactions or extensions of size-based separation. The latter includes geometric restrictions and shape-dependent transport properties.

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“…At room temperature, these superparamagnetic nanoparticles respond to the presence of an external magnetic field and when the field is removed, they return to a non-magnetic state [2]. For this reason, these present good feasibility for biomedical applications and have been used in targeted cancer therapy [3], hyperthermia [4] and drug delivery [5]. Although these materials provide the highest signal enhancements, they can be highly toxic to the body and are extremely sensitive to oxidation.…”

Section: Introductionmentioning

confidence: 99%

Investigating the Structural and Magnetic Properties of Chitosan Coated CoFe2O4 Nanoparticles for Drug Delivery

Mdlalose¹

2020

ABEB

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Magnetic nanoparticles (MNPs) are currently explored for use in biomedical applications, such as in MRI, hyperthermia and drug delivery. In this study, CoFe 2 O 4 and its calcium-substituted derivative viz. CS-Ca 0.5 Co 0.5 Fe 2 O 4 MNPs were synthesised via the glycol-thermal method. Furthermore, these MNPs were coated with chitosan (CS) to improve their biodegradability and biocompatibility. The anti-cancer drug, 5-fluorouracil (5-FU) was then loaded onto these MNPs to yield CS-Ca 0.5 Co 0.5 Fe 2 O 4 -5FU and CS-Ca 0.5 Co 0.5 Fe 2 O 4 -5FU. XRD results confirmed a single-phased cubic spinel structure for all MNPs. The naked MNPs displayed an average crystalline size of ~9.32 nm, which increased up to 18.20 nm upon coating. The VSM measurements recorded saturation magnetization values (Ms) of up to 73.951 emu/g. Upon polymer-coating, the shielding effect of chitosan resulted in reduced Ms of up to 17.220 emu/g in CS-Ca 0.5 Co 0.5 Fe 2 O 4 MNPs. Release profiles were determined at pH 4.5 and 7.4 over a period of 72 hours. A faster release of the drug was noted at the acidic pH with an accumulative release of 91.00% in CS-CoFe2O4-5FU. Coupled with a strong recommendation for in vitro studies, these MNPs present as attractive candidates to complement current anti-cancer treatments.

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Medical Applications of Magnetic Nanoparticles

Cited by 21 publications

References 76 publications

Nano-structural effects on Hematite (α-Fe2O3) nanoparticle radiofrequency heating

Nano-structural effects on Hematite (α-Fe2O3) nanoparticle radiofrequency heating

Shape-based separation of micro-/nanoparticles in liquid phases

Investigating the Structural and Magnetic Properties of Chitosan Coated CoFe2O4 Nanoparticles for Drug Delivery

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