Medical Applications of Collagen and Collagen-Based Materials

Shekhter, Anatoly B.; Fayzullin, Alexey; Vukolova, Marina N.; Rudenko, T. G.; Osipycheva, Varvara D; Litvitsky, P.F.

doi:10.2174/0929867325666171205170339

Cited by 79 publications

(56 citation statements)

References 64 publications

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“…Several types of 3D scaffolds for bone tissue engineering have been reported in the literature [ 18 , 19 ], including hydroxyapatite bioceramics [ 20 ], collagen, atelocollagen, chitosan and alginate (also known as natural macromolecules and their derivatives) [ 21 , 22 , 23 ], polyethylene glycol (synthetic polymer) [ 24 ], hydrogels [ 25 , 26 ], and other materials, such as carbon nanotubes [ 26 , 27 ]. These materials have also been used in combination to achieve superior properties [ 19 , 28 , 29 , 30 , 31 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

In Vivo Regeneration of Large Bone Defects by Cross-Linked Porous Hydrogel: A Pilot Study in Mice Combining Micro Tomography, Histological Analyses, Raman Spectroscopy and Synchrotron Infrared Imaging

et al. 2020

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The transplantation of engineered three-dimensional (3D) bone graft substitutes is a viable approach to the regeneration of severe bone defects. For large bone defects, an appropriate 3D scaffold may be necessary to support and stimulate bone regeneration, even when a sufficient number of cells and cell cytokines are available. In this study, we evaluated the in vivo performance of a nanogel tectonic 3D scaffold specifically developed for bone tissue engineering, referred to as nanogel cross-linked porous-freeze-dry (NanoCliP-FD) gel. Samples were characterized by a combination of micro-computed tomography scanning, Raman spectroscopy, histological analyses, and synchrotron radiation–based Fourier transform infrared spectroscopy. NanoCliP-FD gel is a modified version of a previously developed nanogel cross-linked porous (NanoCliP) gel and was designed to achieve highly improved functionality in bone mineralization. Spectroscopic imaging of the bone tissue grown in vivo upon application of NanoCliP-FD gel enables an evaluation of bone quality and can be employed to judge the feasibility of NanoCliP-FD gel scaffolding as a therapeutic modality for bone diseases associated with large bone defects.

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Section: Discussionmentioning

confidence: 99%

In Vivo Regeneration of Large Bone Defects by Cross-Linked Porous Hydrogel: A Pilot Study in Mice Combining Micro Tomography, Histological Analyses, Raman Spectroscopy and Synchrotron Infrared Imaging

et al. 2020

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“…They may temporarily occupy the body volume and cause limited local host tissue response (limited fibrogenic). Examples of type A fillers include sodium hyaluronate acid (HA), collagen, and acellular matrices (ACMs) …”

Section: Polymeric Injectable Fillersmentioning

confidence: 99%

Polymeric injectable fillers for cosmetology: Current status, future trends, and regulatory perspectives

Zhao

Zhang

et al. 2019

J of Applied Polymer Sci

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Injectable fillers have become a vital part of cosmetology. A wide variety of injectable fillers are developed for either correction of facial wrinkles and folds or facial contouring. As the most popular filler products, polymeric injectable fillers represent a class of the most common implantable medical devices. This review is intended to not only present current filler products, but also share perspectives of future trends, development processes, and regulatory considerations for the next generation of fillers. First, currently approved polymeric injectable fillers are described in detail. Second, future trends of polymeric injectable fillers are discussed. Fillers based on the emerging technologies in tissue engineering and regenerative medicine with stimuli‐responsive or tunable properties, as well as device/drug combination products, are promising candidates. Third, fillers for cosmetology are different from traditionally recognized medical devices. As a result, the target population of such fillers is different from that of other implantable devices, leading to different user needs that impact their development processes. Last, product applications, regulatory requirements, device evaluation, characteristics, and difficulties for regulating filler products for minimally invasive cosmetology are reviewed. Both regulatory science and scientific supervision are needed for polymeric injectable fillers which are facing great opportunities as well as challenges. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48515.

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“…Scientists, by utilizing different materials, tried to advance new scaffolds for cartilage tissue engineering, which could mimic the cartilage's natural ECM three‐dimensional contracture. There are two types of materials that can be used in scaffold fabrication: natural and synthetic polymers . Natural polymers have excellent biocompatibility but low mechanical strength.…”

Section: Introductionmentioning

confidence: 99%

Chondro‐inductive nanofibrous scaffold based gelatin/polyvinyl alcohol/chondroitin sulfate for cartilage tissue engineering

Irani

Honarpardaz

Choubini

et al. 2020

Polymers for Advanced Techs

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Tissue engineering is a technique that can be used for repairing damaged cartilage.The aim of this study was chondro-differentiation of mesenchymal stem cells (MSCs) on polyvinyl alcohol/gelatin/chondroitin sulfate (PVA/GT/CS) blend nanofibers. Nanofibers were fabricated by electrospinning method with different concentrations of CS (10%, 15%, and 20%). MSCs were seeded on nanofibers for biocompatibility and cell viability test by MTT assay. Alcian blue staining assay was done to show that MSCs were differentiated to chondrocyte by staining the glycosaminoglycans (GAGs) that was produced by cells. Reverse transcription polymerase chain reaction (RT-PCR) and immunocytochemistry (ICC) assay were done to confirm type II collagen expression. Scaffolds with different concentrations of CS were tested for biocompatibility, and the nanofiber with 15% of GAG showed better results (P = 0.02) compared with other nanofibers; therefore, it was chosen as the main sample for chondrogenesis tests. On the basis of scanning electron microscopy (SEM), hMSCs had a proper attachment to the nanofiber with 15% CS. Alcian blue staining showed the different rates of blue coloration, which means cells produced different types of GAGs from the GAG we used in the nanofiber. RT-PCR and ICC showed that COL2A1 was expressed in mRNA and protein levels. This study indicates that the PVA/GT/CS nanofiber containing 15% CS can be a good candidate for cartilage tissue engineering. K E Y W O R D S cartilage, chondroitin sulfate, electrospun, mesenchymal stem cells, tissue engineering

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Medical Applications of Collagen and Collagen-Based Materials

Cited by 79 publications

References 64 publications

In Vivo Regeneration of Large Bone Defects by Cross-Linked Porous Hydrogel: A Pilot Study in Mice Combining Micro Tomography, Histological Analyses, Raman Spectroscopy and Synchrotron Infrared Imaging

In Vivo Regeneration of Large Bone Defects by Cross-Linked Porous Hydrogel: A Pilot Study in Mice Combining Micro Tomography, Histological Analyses, Raman Spectroscopy and Synchrotron Infrared Imaging

Polymeric injectable fillers for cosmetology: Current status, future trends, and regulatory perspectives

Chondro‐inductive nanofibrous scaffold based gelatin/polyvinyl alcohol/chondroitin sulfate for cartilage tissue engineering

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