Medical Application of Hydrogen in Hematological Diseases

Qian, Liren; Wu, Zhengcheng; Cen, Jian; Pașca, Sergiu; Tomuleasa, Ciprian

doi:10.1155/2019/3917393

Cited by 14 publications

(12 citation statements)

References 46 publications

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“…We believe that if the administration time is extended, the overall response rate will still rise. Thirdly, the hydrogen molecule is very small, has a strong penetration ability, can quickly penetrate the biofilm, and reach a higher concentration in the cell to play a therapeutic role ( 24 ). Finally, H 2 is cheap and easy to obtain.…”

Section: Discussionmentioning

confidence: 99%

Hydrogen in Patients With Corticosteroid-Refractory/Dependent Chronic Graft-Versus-Host-Disease: A Single-Arm, Multicenter, Open-Label, Phase 2 Trial

et al. 2020

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Chronic graft-versus-host-disease (cGVHD) is the leading cause of late non-relapse mortality after allogeneic hematopoietic stem cell transplantation(HSCT). There is no standard therapy for patients refractory or dependent to corticosteroid treatment. We hypothesized that hydrogen may exert therapeutic effects on cGVHD patients with few side effects. A prospective open-label phase 2 study of hydrogen was conducted. Patients received hydrogen-rich water 4ml/kg orally three times a day. Responses were graded in the skin, mouth, Gastrointestinal(GI), liver, eyes, lungs and joints and fascia every 3 months. A total of 24 patients (median age 27) were enrolled. Of the 24 patients, 18 (75%; 95% CI, 55.1% to 88%) had an objective response. No significant toxicity was observed. The estimated 4-year overall survival rate was 74.7%(95% CI, 54.9%–94.5%). The survival time was significantly prolonged in the response group. The survival rate at 4 years in the response group is significantly higher than the nonresponse group (86.6% vs 0%; p= 0.000132). Hydrogen showed great efficacy on cGVHD patients and long-term administration of hydrogen was not associated with significant toxic effects. The trial was registered at www.ClinicalTrials.Gov, NCT02918188.

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Section: Discussionmentioning

confidence: 99%

Hydrogen in Patients With Corticosteroid-Refractory/Dependent Chronic Graft-Versus-Host-Disease: A Single-Arm, Multicenter, Open-Label, Phase 2 Trial

et al. 2020

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“…Thanks to this discovery, hydrogen gas has been used in 300 diseases and have come to the forefront of therapeutic medical gas research. Clinical research has shown that hydrogen is an essential physiological regulator factor with anti-inflammatory and antioxidant effects on cells and organs [ 15 , 16 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Topical Hydrogen Purification on Skin Parameters and Acne Vulgaris in Adult Women

2021

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Background: Acne vulgaris is a prevalent dermatological disease characterized by skin eruptions, which may decrease the sufferer’s quality of life. Hydrogen purification treatment is a new procedure used in cosmetology to improve the skin parameters of the face. This study examined the effectiveness of hydrogen purification treatment to improve women’s skin conditions with regard to acne vulgaris. Methods: In this study, 30 women participated who suffered from a high level of sebum and acne. The control group was comprised of 30 healthy women with a low level of sebum. The Hellgren–Vincent Scale and Derma Unit SSC 3 device were used to assess acne vulgaris severity and skin properties, respectively. Four hydrogen purification sessions were carried out at 7-day intervals, using the Hebe Hydrogenium+ generating alkaline water. Results: At baseline and 7 and 14 days after finishing the series of treatments, the levels of oiliness, moisture, and skin pH were tested. The main effects of treatment were significant in the following parameters: pH around the bottom lip, moisture between the eyebrows and around the nose, and oily skin in all three face sites. Conclusions: The level of sebum decreased and moisture levels increased during hydrogen purification. Topical hydrogen purification is an effective and safe treatment for acne vulgaris.

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“…Hydrogen (H 2 ) is the oldest and simplest molecule in our Universe. It can protect a variety of organ injuries as well due to its antioxidation, anti-inflammatory, and antiapoptotic effects [12,13]. Interestingly, H 2 has a remarkable therapeutic effect on various diseases, including organ ischemiareperfusion injury and sepsis [14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

“…Molecular hydrogen was previously taken as an inert gas into account, while a research reported that it has antioxidant, anti-inflammatory, and antiapoptotic properties, with organ protection for a variety of acute and chronic diseases [12,13]. In an animal model of intestinal I/R injury, H 2 can simultaneously reduce local intestinal damage and distant organs damage [12,18,19].…”

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confidence: 99%

Amelioration of Coagulation Disorders and Inflammation by Hydrogen-Rich Solution Reduces Intestinal Ischemia/Reperfusion Injury in Rats through NF-κB/NLRP3 Pathway

Yang

Guo

Fan

et al. 2020

Mediators of Inflammation

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Intestinal ischemia/reperfusion (I/R) injury often causes inflammatory responses and coagulation disorders, which is further promoting the deterioration of the disease. Hydrogen has anti-inflammatory, antioxidative, and antiapoptotic properties against various diseases. However, the effect of hydrogen on coagulation dysfunction after intestinal I/R and the underlying mechanism remains unclear. The purpose of this study was to explore whether hydrogen-rich solution (HRS) could attenuate coagulation disorders and inflammation to improve intestinal injury and poor survival following intestinal I/R. The rat model of intestinal I/R injury was established by clamping the superior mesenteric artery for 90 min and reperfusion for 2 h. HRS (10 or 20 mL/kg) or 20 mL/kg 0.9% normal saline was intravenously injected at 10 min before reperfusion, respectively. The samples were harvested at 2 h after reperfusion for further analyses. Moreover, the survival rate was observed for 24 h. The results showed that HRS improved the survival rate and alleviated serum diamine oxidase activities, intestinal injury, edema, and apoptosis. Interestingly, HRS markedly improved intestinal I/R-mediated coagulation disorders as evidenced by abnormal conventional indicators of coagulation and thromboelastography. Additionally, HRS attenuated inflammatory responses and the elevated tissue factor (TF) and inhibited nuclear factor kappa beta (NF-κB) and nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation in peripheral blood mononuclear cells. Moreover, inflammatory factors and myeloperoxidase were closely associated with TF level. This study thus emphasized upon the amelioration of coagulation disorders and inflammation by HRS as a mechanism to improve intestinal I/R-induced intestinal injury and poor survival, which might be partially related to inhibition of NF-κB/NLRP3 pathway.

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Medical Application of Hydrogen in Hematological Diseases

Cited by 14 publications

References 46 publications

Hydrogen in Patients With Corticosteroid-Refractory/Dependent Chronic Graft-Versus-Host-Disease: A Single-Arm, Multicenter, Open-Label, Phase 2 Trial

Hydrogen in Patients With Corticosteroid-Refractory/Dependent Chronic Graft-Versus-Host-Disease: A Single-Arm, Multicenter, Open-Label, Phase 2 Trial

Effects of Topical Hydrogen Purification on Skin Parameters and Acne Vulgaris in Adult Women

Amelioration of Coagulation Disorders and Inflammation by Hydrogen-Rich Solution Reduces Intestinal Ischemia/Reperfusion Injury in Rats through NF-κB/NLRP3 Pathway

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