Mediators of inflammation in children with type I diabetes mellitus: cytokines in type I diabetic children

Erbağcı, Ahmet; Tarakçıoğlu, Mehmet; Coşkun, Yavuz; Sivaslı, Ercan; Namiduru, Emine Siber

doi:10.1016/s0009-9120(01)00275-2

Cited by 115 publications

(122 citation statements)

References 29 publications

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“…Thus elevated plasma IL-6 and TNF-α levels have been reported in newly diagnosed patients with [6] or without DKA [9], in comparison with those with longer standing diabetes, suggesting a possible activation of systemic inflammatory process during early phases of T1DM [9]. Moreover, in the same group of patients, IL-8 levels did not significantly change throughout the various stages of severe DKA [9], which was also observed in our study. However in patients with a long-standing diabetes without DKA, among all cytokines, only the IL-8 levels were found to be significantly increased [9].…”

Section: Discussionsupporting

confidence: 84%

“…Cytokine levels have been reported to differ during the metabolic crisis of DKA at T1DM diagnosis and in patients with a longer (>1year) diabetes duration [9]. Thus elevated plasma IL-6 and TNF-α levels have been reported in newly diagnosed patients with [6] or without DKA [9], in comparison with those with longer standing diabetes, suggesting a possible activation of systemic inflammatory process during early phases of T1DM [9].…”

Section: Discussionmentioning

confidence: 99%

“…Chemokines play a central role in inflammatory processes by regulating leukocyte migration into sites of tissue damage [9]. IL-6 is secreted by macrophages, lymphocytes and other cells [10].…”

Section: Methodsmentioning

confidence: 99%

“…Thus patients with diabetes have elevated blood levels of IL-6, which, together with TNF-α are known to increase inflammation and the development of vascular disease and atherosclerosis, possibly by increasing oxidative stress [12,14,15,16]. In children with T1DM, IL-6 levels were found to be statistically significantly increased in the group with long T1DM duration, as well as in those newly diagnosed, when compared with healthy controls [6,9], with the highest levels in the newly diagnosed patients [9].…”

Section: Methodsmentioning

confidence: 99%

“…Although there are some previous studies on the role of cytokines in the development of long-term diabetes complications [6,9,12,14,15,16], there is only one study on the fluctuation of cytokines during the metabolic crisis of DKA in children with T1DM [6], including limited number of patients. The aim of the present study was to monitor serum levels of pro-inflammatory cytokines IL-1β, IL-2, IL-6, IL-8 and TNF-α and the anti-inflammatory cytokine IL-10 at different time-points during the management of DKA, as markers of the risk of development of its acute complications.…”

mentioning

confidence: 99%

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Cytokine response to diabetic ketoacidosis (DKA) in children with type 1 diabetes (T1DM)

et al. 2011

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Cytokine response to diabetic ketoacidosis (DKA) in children with type 1 diabetes (T1DM)

et al. 2011

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Exercise and Type 1 Diabetes (T1DM)

Galassetti

Riddell

2013

Comprehensive Physiology

113

118

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Physical exercise is firmly incorporated in the management of type 1 diabetes (T1DM), due to multiple recognized beneficial health effects (cardiovascular disease prevention being preeminent). When glycemic values are not excessively low or high at the time of exercise, few absolute contraindications exist; practical guidelines regarding amount, type, and duration of age-appropriate exercise are regularly updated by entities such as the American Diabetes Association and the International Society for Pediatric and Adolescent Diabetes. Practical implementation of exercise regimens, however, may at times be problematic. In the poorly controlled patient, specific structural changes may occur within skeletal muscle fiber, which is considered by some to be a disease-specific myopathy. Further, even in well-controlled patients, several homeostatic mechanisms regulating carbohydrate metabolism often become impaired, causing hypo- or hyperglycemia during and/or after exercise. Some altered responses may be related to inappropriate exogenous insulin administration, but are often also partly caused by the "metabolic memory" of prior glycemic events. In this context, prior hyperglycemia correlates with increased inflammatory and oxidative stress responses, possibly modulating key exercise-associated cardio-protective pathways. Similarly, prior hypoglycemia correlates with impaired glucose counterregulation, resulting in greater likelihood of further hypoglycemia to develop. Additional exercise responses that may be altered in T1DM include growth factor release, which may be especially important in children and adolescents. These multiple alterations in the exercise response should not discourage physical activity in patients with T1DM, but rather should stimulate the quest for the identification of the exercise formats that maximize beneficial health effects.

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Loss of interleukin‐10 exacerbates early Type‐1 diabetes‐induced bone loss

Rios‐Arce

Dagenais

Feenstra

et al. 2019

Journal Cellular Physiology

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Type-1 diabetes (T1D) increases systemic inflammation, bone loss, and risk for bone fractures. Levels of the anti-inflammatory cytokine interleukin-10 (IL-10) are decreased in T1D, however their role in T1D-induced osteoporosis is unknown. To address this, diabetes was induced in male IL-10 knockout (KO) and wild-type (WT) mice. Analyses of femur and vertebral trabecular bone volume fraction identified bone loss in T1D-WT mice at 4 and 12 weeks, which in T1D-IL-10-KO mice was further reduced at 4 weeks but not 12 weeks. IL-10 deficiency also increased the negative effects of T1D on cortical bone. Osteoblast marker osterix was decreased, while osteoclast markers were unchanged, suggesting that IL-10 promotes anabolic processes. MC3T3-E1 osteoblasts cultured under high glucose conditions displayed a decrease in osterix which was prevented by addition of IL-10. Taken together, our results suggest that IL-10 is important for promoting osteoblast maturation and reducing bone loss during early stages of T1D.

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Mediators of inflammation in children with type I diabetes mellitus: cytokines in type I diabetic children

Cited by 115 publications

References 29 publications

Cytokine response to diabetic ketoacidosis (DKA) in children with type 1 diabetes (T1DM)

Cytokine response to diabetic ketoacidosis (DKA) in children with type 1 diabetes (T1DM)

Exercise and Type 1 Diabetes (T1DM)

Loss of interleukin‐10 exacerbates early Type‐1 diabetes‐induced bone loss

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