Mediation of Cognitive Function Improvements by Strength Gains After Resistance Training in Older Adults with Mild Cognitive Impairment: Outcomes of the Study of Mental and Resistance Training

Mavros, Yorgi; Gates, Nicola; Wilson, Guy C; Jain, Nidhi; Meiklejohn, Jacinda; Brodaty, Henry; Wang, Wen; Singh, Nalin; Baune, B.; Suo, Chao; Baker, Michael K.; Foroughi, Nasim; Wang, Yichuan; Sachdev, Perminder S.; Valenzuela, Michael; Singh, Maria A. Fiatarone

doi:10.1111/jgs.14542

Cited by 113 publications

(98 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In these two studies, patients of the experimental group increased their cognition relatively more than the control group after intervention, both for the ADAS-Cog and the MMSE. Other studies showed no significant differences between the conditions with regard to cognition [34,35,45,46,49,51,55,57,58]. Studies that used other assessment tools to measure cognitive impairment showed also positive effects.…”

Section: Skills Training Trialsmentioning

confidence: 94%

“…In particular, Herrera et al [43] found an effect on working memory and recall, where patients improved better than controls after the intervention. Law et al [47] found a positive effect on verbal learning and on the TMT-A, whereby patients in the intervention group showed better functioning than the control, and Mavros et al [49] found that participants of the intervention group scored relatively better on the BVRT and memory domain than control. Ngandu et al [52] found that patients scored better at executive functioning, processing speed, and memory after the intervention compared to the control conditions.…”

Section: Skills Training Trialsmentioning

confidence: 99%

See 1 more Smart Citation

Cognitive Therapy for Dementia Patients: A Systematic Review

Carrión

Folkvord

Anastasiadou

et al. 2018

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

Background: Cognitive therapy is a well-established intervention for treating elderly suffering from dementia. In particular, reality orientation and skills training seem to be effective interventions for reversing cognitive impairment among elderly, although findings are inconclusive. Therefore, a systematic update of the existing evidence of cognitive therapy for people suffering from dementia is needed. Aim: To review existing scientific evidence regarding the efficacy of cognitive therapies for elderly suffering from dementia. Methods: Studies were retrieved from several bibliographic databases (January 2009 to December 2017) with prespecified selection criteria, data extraction, and methodological quality assessment. Results: In total, 10 reality orientation, 25 skills training, and 12 mixed trials were identified as meeting the inclusion criteria and were systematically reviewed. Results from reality orientation trials showed minor effects for cognitive assessments, while skills training trials and mixed trials showed contradicting effects on cognition. Effects on other outcomes (e.g., daily functioning, depression, language) were limited or not found. Conclusions: Skills training trials and mixed trials seem to affect cognitive impairment in a positive way, although the results are inconclusive. Comparison between studies was difficult due to differences in form of intervention. Because findings are inconclusive, more structuralized and comparable randomized controlled trials are needed.

show abstract

Section: Skills Training Trialsmentioning

confidence: 94%

Section: Skills Training Trialsmentioning

confidence: 99%

Cognitive Therapy for Dementia Patients: A Systematic Review

Carrión

Folkvord

Anastasiadou

et al. 2018

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

show abstract

“…The preponderance of research on the effects of exercise on cognition in aging has used aerobic exercise. However, strength training may provide separate or additional benefit to the brain . Even less research has been conducted on the effects of nonexercise movement that reduces sedentary time, which may be an important part of an exercise prescription for maintaining cognition.…”

Section: Discussionmentioning

confidence: 99%

Cognitive Effects of Adding Caloric Restriction to Aerobic Exercise Training in Older Adults with Obesity

Hugenschmidt

Leng

Lyles

et al. 2019

Obesity

View full text Add to dashboard Cite

Objective This study examined the short and long-term effects of adding caloric restriction to five months of aerobic exercise training on executive function in sedentary older adults with obesity. Methods Sedentary years adults with obesity aged 65–79 completed a randomized trial investigating the cardiorespiratory benefits of adding moderate (~250kcal) or high (~600kcal) caloric restriction to a 20-week aerobic exercise program. Approximately half (n=88) completed a cognitive assessment battery at baseline, post-intervention, and 18–24 months after intervention completion. The primary outcome was an executive function composite score. Results In the overall sample, the executive function composite increased 0.114 from baseline to post-intervention (p=0.01). Randomization to caloric restriction did not significantly alter executive function over aerobic exercise alone, nor were there between-group differences on any individual executive function test at post-intervention or long-term follow-up. Adding caloric restriction to exercise was associated with a modest increase in MMSE score (p=0.04). In the overall sample, increases from baseline at long-term follow-up were noted in digit symbol and word list recall performance as well. Conclusions Adding caloric restriction to a 20-week aerobic exercise program does not worsen or improve executive function more than exercise alone assessed up to 24 months post-randomization.

show abstract

“…https://doi.org/10.1101/19005249 doi: medRxiv preprint Aerobic capacity (VO 2 peak) was determined via indirect calorimetry during a physicianadministered, graded treadmill walking test to volitional fatigue. Methods and data handling have been previously published 16 . Table 1.…”

Section: Assessment Of Peak Aerobic Capacitymentioning

confidence: 99%

Impairment of dual-task gait dynamics in older adults with mild cognitive impairment: Relationships to neuropsychological status, fitness and brain morphology

Hawkins

Samuel

Singh

et al. 2019

Preprint

Self Cite

View full text Add to dashboard Cite

Background: Individuals with Mild Cognitive Impairment (MCI) have more gait variability under dual-task conditions than cognitively healthy adults. However, characteristics associated with this susceptibility of gait to dual-task stress are unknown. Methods: Testing was performed at baseline in the Study of Mental And Resistance Training (SMART). Ninety-three adults with MCI (age 70±6.8 years; 66.6% female) performed a single- and dual-task walk (cognitive distractor=letter fluency), in random order. Linear and non-linear gait variability were measured using force-sensitive insoles. Cognitive performance during dual-tasking was assessed by the number of correct words vocalized. Cognitive function, brain Magnetic Resonance Imaging (MRI), muscle strength, aerobic capacity, body composition, physical and psychosocial function were also assessed as potential correlates of gait dynamics. Results: Gait dynamics worsened during dual-tasking, with decrements in both stride time variability (p<0.001) and detrended fluctuation analysis (DFA) (p=0.001). Lower aerobic capacity and thinner posterior cingulate cortex were associated with greater decrements in DFA (p<0.05). Smaller hippocampal volume, worse psychological well-being and poorer static balance were associated with greater decrements in stride time variability (p<0.05). By contrast, cognitive performance did not change under dual-task conditions compared to seated testing (p=0.13). Conclusions: Under dual-task conditions, participants with MCI preserved their cognitive performance at the expense of gait stability. Decrements in dual-tasking gait were associated with lower aerobic fitness, balance, psychological well-being, and brain volume in cognitively-relevant areas of the posterior cingulate and hippocampus, all potentially modifiable characteristics. Trials of targeted interventions are needed to determine the potential plasticity of gait variability in high-risk cohorts.

show abstract

Mediation of Cognitive Function Improvements by Strength Gains After Resistance Training in Older Adults with Mild Cognitive Impairment: Outcomes of the Study of Mental and Resistance Training

Cited by 113 publications

References 37 publications

Cognitive Therapy for Dementia Patients: A Systematic Review

Cognitive Therapy for Dementia Patients: A Systematic Review

Cognitive Effects of Adding Caloric Restriction to Aerobic Exercise Training in Older Adults with Obesity

Impairment of dual-task gait dynamics in older adults with mild cognitive impairment: Relationships to neuropsychological status, fitness and brain morphology

Contact Info

Product

Resources

About