“…Ca 2 + as a Second Messenger A [Ca 2 +]i increase controls widely different cellular processes, such as activation of some cytosolic enzymes (Schulman, 1998), gene transcription (Bito et al, 1997;Hardingham et al, 1997: Chawla andBading, 1998;Deisseroth et al, 1998), fertilization (Galione et al, 1993a;Lee et aI., 1993;Marchant and Parker, 1998), cell proliferation and differentiation (Berridge, 1995;Archer et al, 1998), apoptosis (Jayaraman and Marks, 1998), cell contraction (Meissner, 1994;Liu et aI., 1997), photoreception (Berridge, 1997), intracellular membrane fusion (Peters and Mayer, 1998), exocytosis, including neurotransmitter release (Lindau et al, 1992;Neher and Zucker, 1993;Regehr and Atluri, 1995;Henkel and Almers, 1996;Huang and Neher, 1996;Berridge, 1998;Kasai, 1999), endocytosis (Artalejo et al, 1995;Henkel and Almers, 1996), phagocytosis (Kruskal and Maxfield, 1987;Randriamampita et al, 1991;Ohmer-Schrock et al, 1995), amoeboid movement (Gilbert et al, 1994), and ciliary beat regulation (Lansley and Sanderson, 1999). For reviews, see Berridge (1997), Berridge et al (1998), and Verkhratsky and Toescu (1998).…”