Mediation effect of body mass index on the association between serum magnesium level and insulin resistance in children from Mexico City

Rios-Lugo, María Judith; Serafín-Fabián, Jesús Isimar; Hernández-Mendoza, Héctor; Klünder-Klünder, Miguel; Cruz, Miguel; Chavez-Prieto, Estefania; Martínez- Navarro, Israel; Vilchis-Gil, Jenny; Vazquez-Moreno, Miguel

doi:10.1038/s41430-024-01447-3

Eur J Clin Nutr

2024

DOI: 10.1038/s41430-024-01447-3

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Mediation effect of body mass index on the association between serum magnesium level and insulin resistance in children from Mexico City

María Judith Rios-Lugo,

Jesús Isimar Serafín-Fabián,

Héctor Hernández-Mendoza

et al.

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Magnesium: A Defense Line to Mitigate Inflammation and Oxidative Stress in Adipose Tissue

Cazzola,

Della Porta,

Piuri

et al. 2024

Antioxidants

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Magnesium (Mg) is involved in essential cellular and physiological processes. Globally, inadequate consumption of Mg is widespread among populations, especially those who consume processed foods, and its homeostasis is impaired in obese individuals and type 2 diabetes patients. Since Mg deficiency triggers oxidative stress and chronic inflammation, common features of several frequent chronic non-communicable diseases, interest in this mineral is growing in clinical medicine as well as in biomedicine. To date, very little is known about the role of Mg deficiency in adipose tissue. In obesity, the increase in fat tissue leads to changes in the release of cytokines, causing low-grade inflammation and macrophage infiltration. Hypomagnesemia in obesity can potentiate the excessive production of reactive oxygen species, mitochondrial dysfunction, and decreased ATP production. Importantly, Mg plays a role in regulating intracellular calcium concentration and is involved in carbohydrate metabolism and insulin receptor activity. This narrative review aims to consolidate existing knowledge, identify research gaps, and raise awareness of the critical role of Mg in supporting adipose tissue metabolism and preventing oxidative stress.

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Magnesium: A Defense Line to Mitigate Inflammation and Oxidative Stress in Adipose Tissue

Cazzola,

Della Porta,

Piuri

et al. 2024

Antioxidants

View full text Add to dashboard Cite

show abstract

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Mediation effect of body mass index on the association between serum magnesium level and insulin resistance in children from Mexico City

Cited by 1 publication

References 42 publications

Magnesium: A Defense Line to Mitigate Inflammation and Oxidative Stress in Adipose Tissue

Magnesium: A Defense Line to Mitigate Inflammation and Oxidative Stress in Adipose Tissue

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