Mediating role of oxidative/nitrosative stress biomarkers in the associations between phthalate exposure and thyroid function in Taiwanese adults

Huang, Po-Chin; Waits, Alexander; Chen, Hsin‐Chang; Chang, Wan‐Ting; Jaakkola, Jouni J. K.; Huang, Han-Bin

doi:10.1016/j.envint.2020.105751

Cited by 27 publications

(14 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…8-OHdG is the OSB commonly measured in environmental health investigations. Studies have linked exposure to phthalates [ 14 , 33 – 35 ], BPA [ 15 , 16 ], organophosphate esters (OPEs) [ 36 ], or pesticides [ 37 , 38 ] with elevated urinary 8-OHdG. Simultaneous determination of 8-OHdG and 8-NG has been used to assess link between oxidative and/or nitrative damage and exposures to per- and polyfluoroalkyl substances [ 12 ], phthalates [ 14 ], or BPA [ 15 ].…”

Section: Resultsmentioning

confidence: 99%

“…Studies have linked exposure to phthalates [ 14 , 33 – 35 ], BPA [ 15 , 16 ], organophosphate esters (OPEs) [ 36 ], or pesticides [ 37 , 38 ] with elevated urinary 8-OHdG. Simultaneous determination of 8-OHdG and 8-NG has been used to assess link between oxidative and/or nitrative damage and exposures to per- and polyfluoroalkyl substances [ 12 ], phthalates [ 14 ], or BPA [ 15 ]. Oxidized serum guanine (e.g., 8-OHdG, 8-HG, 8-HdG) has been associated with COVID-19 mortality [ 39 ], and elevated serum levels of 8-HG, 8-HdG, or 8-NdG have been linked to mortality associated with traumatic brain injury [ 18 ].…”

Section: Resultsmentioning

confidence: 99%

“…Oxidative damage to DNA by ROS can generate 8-hydroxy-2′-deoxyguanosine (8-OHdG) and 8-hydroxyguanine (8-HG), whereas that by RNS can yield 8-nitroguanine (8-NG). Reactions of ROS and RNS with RNA produce 8-hydroxyguanosine (8-HdG) and 8-nitroguanosine (8-NdG), respectively [ 12 , 14 , 18 ]. The biomarkers of oxidative damage to polyunsaturated fatty acids (PUFA) by ROS are malondialdehyde (MDA) and 4-hydroxynonenal (HNE) [ 19 , 20 ]; the oxidation of arachidonic acid (a fatty acid found in the liver, brain, and glands) can produce prostaglandin isomers, 8-isoprostaglandin F 2α (8-PGF 2α ), 11-β-prostaglandin F 2α (11-PGF 2α ), 15-prostaglandin F 2α (15-PGF 2α ), and 8-iso-15-prostaglandin F 2α (8,15-PGF 2α ) [ 21 ]; and uric acid oxidation yields allantoin (Alla) [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Analysis of 19 urinary biomarkers of oxidative stress, nitrative stress, metabolic disorders, and inflammation using liquid chromatography–tandem mass spectrometry

Martinez-Moral

2022

Anal Bioanal Chem

View full text Add to dashboard Cite

Graphical abstract Environmental chemical exposures have been associated with cancer, diabetes, hormonal and immunological disorders, and cardiovascular diseases. Some direct effects of chemical exposure that are precursors to adverse health outcomes, including oxidative stress, nitrative stress, hormonal imbalance, neutrophilia, and eosinophilia, can be assessed through the analysis of biomarkers in urine. In this study, we describe a novel methodology for the determination of 19 biomarkers of health effects: malondialdehyde (MDA), 8-isoprostaglandin-F 2α (8-PGF 2α ), 11-β-prostaglandin-F 2α (11-PGF 2α ), 15-prostaglandin-F 2α (15-PGF 2α ), 8-iso-15-prostaglandin-F 2α (8,15-PGF 2α ), 8-hydroxy-2′-deoxyguanosine (8-OHdG), 8-hydroxyguanosine (8-HdG), 8-hydroxyguanine (8-HG), dityrosine (diY), allantoin (Alla), and two metabolic products of 4-hydroxynonenal (HNE), namely 4-hydroxy-2-nonenal glutathione (HNE-GSH) and 4-hydroxy-2-nonenal mercapturic acid (HNE-MA) (in total, 12 oxidative stress biomarkers, OSBs); 8-nitroguanosine (8-NdG), 8-nitroguanine (8-NG), and 3-nitrotyrosine (NY) (3 nitrative stress biomarkers, NSBs); chlorotyrosine (CY) and bromotyrosine (BY) (2 inflammatory biomarkers); and the advanced glycation end-products (AGEs) N ε -carboxymethyllysine (CML) and N ε -carboxyethyllysine (CEL) (2 metabolic disorder biomarkers). Since these biomarkers are trigged by a variety of environmental insults and produced by different biomolecular pathways, their selective and sensitive determination in urine would help broadly elucidate the pathogenesis of diseases mediated by environmental factors.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Analysis of 19 urinary biomarkers of oxidative stress, nitrative stress, metabolic disorders, and inflammation using liquid chromatography–tandem mass spectrometry

Martinez-Moral

2022

Anal Bioanal Chem

View full text Add to dashboard Cite

show abstract

“…Phthalates are ubiquitous in daily life. They are added to plastics and many other daily products [18,19]. From 2003 to 2007, an average of 200,000 tons of di (2-ethylhexyl)phthalate (DEHP) and 20,000 tons of dibutyl phthalate (DBP) were used to produce consumer products in Taiwan [20].…”

Section: Introductionmentioning

confidence: 99%

“…Phthalates have also been suggested as having a possible antagonistic effect on thyroid functions [34][35][36][37][38][39][40] and may alter thyroid hormone through the oxidative stress pathway [19,41,42]. This may be relevant to other environmental disrupter compounds [1,40,43,44].…”

Section: Introductionmentioning

confidence: 99%

Prenatal Phthalates Exposure and Cord Thyroid Hormones: A Birth Cohort Study in Southern Taiwan

Huang

Kuo

Chang

et al. 2021

IJERPH

Self Cite

View full text Add to dashboard Cite

Background: The regulation of thyroid hormones in the early stages of gestation plays a crucial role in the outcome of a pregnancy. Furthermore, thyroid hormones are fundamental for the fetal development of all organs, including endocrine hormone changes in uterus. Endocrine disrupting chemicals have been shown to have an effect on thyroid hormone homeostasis in newborns, which affects their later development. Few studies have proposed how phthalates could alter thyroid function through several mechanisms and the possible effects on thyroid hormone homeostasis of phthalates on pregnant women. However, the effects of cord blood phthalates and prenatal phthalate exposure on thyroid hormones in newborns remain unclear. Objectives: We aim to follow up on our previous established subjects and determine the correlation between phthalate exposure and thyroid hormones in pregnant women and newborns. Materials and methods: We recruited 61 pregnant women from the Obstetrics and Gynecology Department of a medical hospital in southern Taiwan and followed up. High performance liquid chromatography electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS) was used to analyze urine samples for five phthalate metabolites. Serum levels of thyroid hormones were analyzed using electrochemoluminescence immunoassay (ECLIA) method. We used Spearman and Pearson correlation coefficients to evaluate the correlation between each phthalate metabolites in serum and the thyroid hormone levels in fetus and parturient. Finally, multiple logistic regression was used to explore the relationship between hormones and their corresponding phthalate metabolites in cord blood. Results: High MBP in cord blood was correlated with negative cord serum TSH in newborns (r = −0.25, p < 0.06). By using multiple linear regression after adjusting for potential confounders (gestational and maternal age), cord serum MBP levels showed a negative association with cord serum TSH (β = 0.217, p < 0.05), cord serum T4 (β = 1.71, p < 0.05) and cord serum T4 × TSH (β = 42.8, p < 0.05), respectively. Conclusion: We found that levels of cord serum TSH and T4 in newborns was significantly negatively associated with cord serum MBP levels after adjusting for significant covariate. The fall in TSH in newborns may potentially be delaying their development.

show abstract

Exposure to barium and blood pressure in children and adolescents: results from the 2003–2018 National Health and Nutrition Examination Survey

Hao

Wang

et al. 2022

Environ Sci Pollut Res

View full text Add to dashboard Cite

Mediating role of oxidative/nitrosative stress biomarkers in the associations between phthalate exposure and thyroid function in Taiwanese adults

Cited by 27 publications

References 56 publications

Analysis of 19 urinary biomarkers of oxidative stress, nitrative stress, metabolic disorders, and inflammation using liquid chromatography–tandem mass spectrometry

Analysis of 19 urinary biomarkers of oxidative stress, nitrative stress, metabolic disorders, and inflammation using liquid chromatography–tandem mass spectrometry

Prenatal Phthalates Exposure and Cord Thyroid Hormones: A Birth Cohort Study in Southern Taiwan

Exposure to barium and blood pressure in children and adolescents: results from the 2003–2018 National Health and Nutrition Examination Survey

Contact Info

Product

Resources

About