Mediastinal Synovial Sarcoma: A Case Report and Literature Review

Cheng, Suet-Lai; Tse, Gary; Li, Wilson W. L.; Lee, T. W.; Yim, Anthony P.C.

doi:10.1155/2003/681919

Cited by 5 publications

(4 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Common symptoms include chest pain, shortness of breath, hemoptysis and cough. However, most patients present with a slow growing, painless mass, in a way similar to our case [6,8,13].…”

Section: Discussionsupporting

confidence: 62%

“…Although synovial sarcoma has been reported to metastasis to the mediastinum, its occurrence as primary neoplasm in this location is rare and has only recently been recognized. Only a few reports and series of primary synovial sarcoma of the mediastinum are described in the literature and all reported cases does not exceed forty so far [2][3][4][6][7][8][9][10][11][12][13][14][15].…”

Section: Discussionmentioning

confidence: 99%

“…Enhanced Computed Tomography and MRI has been the traditional imaging tool for assessment of this type of pathology but more recently, Positron Emission Tomography (PET CT) were used showing increased 18F-FDG uptake by the primary tumor, it permitted to identify other foci that may represent metastatic disease. Combined PET CT imaging is likely to become the imaging modality of choice for follow up of patients with these rare tumors [4,8,11].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Primary Synovial Sarcoma of the Mediastinum: A Case Report and Review of the Literature

Ouji¹,

Souissi²,

Mbarek³

et al. 2015

J Clin Case Rep

View full text Add to dashboard Cite

Background: Synovial sarcomas most commonly occur in the soft tissues of the extremities of young adults. A primary occurrence in the mediastinum is very rare with only a few reported cases in the world literature. Study aims: to insist on the rarity of this pathology, its imaging features and the importance for recognizing unusual presentation of this aggressive neoplasm to aid appropriate clinical management. Cases: Here in, we report a rare case of primary monophasic spindle cell synovial sarcoma of the mediastinum in a 31-year-old man who had an incidental finding of such a tumor. The imaging studies on admission showed 12 cm anterior-middle mediastinal mass with multiple metastases in the lung, pleura, mediastinal lymph nodes and spine. An ultrasound-guided percutaneous needle biopsy of a cervical extension of the mass permitted histopathology and immuno histochemical analysis which supported the diagnosis of monophasic spindle cell synovial sarcoma. The patient was treated by chemo-therapy without response. Conclusion: A wide range of neoplasms both primary and metastatic occurs in the mediastinum which poses considerable diagnostic difficulties. A synovial sarcoma should be considered in the differential diagnosis. Imaging can guide percutaneous needle biopsy of the tumor and evaluate its stage. Immunohistochemistry can be very helpful for an accurate diagnosis. Figure 1: PA and lateral chest x ray show a mass of the anterior-middle mediastinum displacing the trachea to the right side with multiple metastatic pulmonary nodules.

show abstract

“…Common symptoms include chest pain, shortness of breath, hemoptysis and cough. However, most patients present with a slow growing, painless mass, in a way similar to our case [6,8,13].…”

Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Primary Synovial Sarcoma of the Mediastinum: A Case Report and Review of the Literature

Ouji¹,

Souissi²,

Mbarek³

et al. 2015

J Clin Case Rep

View full text Add to dashboard Cite

show abstract

“…Evidence suggests that SS arises from primitive pluripotential mesenchyme capable of synovial differentiation explaining non-extremity involvement [2,4]. SS is most commonly found in adolescents and young adults [3,10] but is also seen in children [7–9].…”

Section: Discussionmentioning

confidence: 99%

Synovial sarcoma leading to a paraesophageal abscess in a child.

et al. 2012

View full text Add to dashboard Cite

SummaryBackground:Synovial sarcoma (SS) is an uncommon malignant neoplasm arising from primitive pluripotential mesenchyme primarily affecting the soft tissues of the extremities. Rarely other locations are involved, including the mediastinum.Case Report:After treatment for mediastinal SS by surgical resection, radiation therapy, and chemotherapy, an 11-year-old boy developed an esophageal stricture and fistula, the latter resulting in a paraesophageal abscess. Management of the esophageal stricture and fistula required a multi-disciplinary approach. We report our experience with the management of this difficult complication, as well as a brief review of the literature on SS.Conclusions:Rare conditions, particularly those with unusual complications, present therapeutic challenges requiring a multi-disciplinary team approach. Reporting experiences with difficult cases can benefit providers faced with similar problems in the future.

show abstract