Mediastinal schwannoma mimicking lymph node metastasis from locally advanced breast cancer in a 18 F-FDG PET/CT study

Martínez-Esteve, A.; Álvarez-Pérez, R.M.; Pachón-Garrudo, V.M.; González-Mancha, R.; Borrego-Dorado, I.

doi:10.1016/j.remnie.2015.11.005

Cited by 2 publications

(4 citation statements)

References 3 publications

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“…The location and composition through imaging studies are critical to make a differential diagnosis. Even through sophisticated studies such a 18 F-uorodeoxyglucose positron emission tomography and computed tomography ( 18 F-FDG PET/CT), mediastinal schwannoma can simulate metastases to breast cancer lymph nodes, as shown by Martinez-Esteve et al [16] Similarly, we found a patient with a clinical history of stage IIB breast cancer during follow-up showed a mediastinal mass on a chest X-ray that was initially thought to be a recurrence of the disease. However, when a CT scan was performed, the site of origin of the tumor was de ned precisely and it proposed that it could correspond to schwannoma.…”

Section: Discussionmentioning

confidence: 51%

“…Mediastinal schwannomas can be misdiagnosed as lymph node metastasis from locally advanced breast cancer. [16] The clinical distinction between mediastinal schwannoma and metastasis in cases that have a history of cancer, can be di cult and requires its surgical removal and histopathological analysis. The location and composition through imaging studies are critical to make a differential diagnosis.…”

Section: Discussionmentioning

confidence: 99%

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Retrospective Analysis of the Clinical and Image Presentation of Eight Primary Benign Mediastinal Schwannomas

Sandoval-Macias¹,

Ortiz-Sanchez²,

Remirez-Castellanos³

et al. 2021

Preprint

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Objective: Mediastinal schwannomas sometimes can be confused with other neoplasms in the initial radiological studies, especially when there is a history of cancer in another site and that require a more accurate analysis by computed tomography (CT) or even magnetic resonance (MRI). Our study was aimed to perform a retrospective analysis of the clinical and imaging features in a series of patients with mediastinal schwannomas that were confirmed by histology and immunohistochemistry.Results: We found eight patients, five man and three women with an average age of 51 years. The main signs and symptoms at time of diagnosis were chest pain, dyspnea, cough and dysphagia. CT showed that the tumor was located in the posterior compartment of the chest in 7/8 cases. Tumors >10 cm were more heterogeneous and showed cystic changes. All cases underwent posterolateral thoracotomy and radiological follow-up showed no evidence of recurrence. Histological analysis was the gold standard to confirm diagnosis in addition to at least one neurogenic IHC marker. In conclusion, mediastinal schwannomas are benign encapsulated tumors. By CT, schwannomas >10 cm showed cystic degeneration more frequently. Posterolateral thoracotomy allows complete resection and is considered the surgical approach of choice.

show abstract

Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Retrospective Analysis of the Clinical and Image Presentation of Eight Primary Benign Mediastinal Schwannomas

Sandoval-Macias¹,

Ortiz-Sanchez²,

Remirez-Castellanos³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Mediastinal schwannomas can be misdiagnosed as lymph node metastasis [17]. The clinical distinction between mediastinal schwannoma and metastasis in cases where there is a history of cancer can be difficult, and requires surgical removal followed by histopathological analysis.…”

Section: Discussionmentioning

confidence: 99%

“…The location and composition obtained by means of imaging studies are critical to make a differential diagnosis. Even when using sophisticated studies, such a 18 F-fluorodeoxyglucose positron emission tomography and computed tomography ( 18 F-FDG PET/ CT), mediastinal schwannomas can simulate metastases of breast cancer lymph nodes, as shown by Martinez-Esteve et al [17]. Similarly, we found a patient with a clinical history of stage IIB breast cancer during followup, which showed a mediastinal mass on a chest X-ray that was initially thought to be a recurrence of the disease.…”

Section: Discussionmentioning

confidence: 99%

Retrospective analysis of the clinical presentation and imaging of eight primary benign mediastinal schwannomas

et al. 2021

View full text Add to dashboard Cite

Objective Mediastinal schwannomas are sometimes confused with other neoplasms during initial radiological studies, especially when there is a history of cancer in another area. In these cases, a more accurate analysis using computed tomography (CT) or even magnetic resonance (MRI) is required. Our study aimed to perform a retrospective analysis of the clinical and imaging features for a series of patients with mediastinal schwannomas that were confirmed by histology and immunohistochemistry. Results We found eight patients, five men and three women, with an average age of 51 years for this study. The main signs and symptoms at diagnosis were chest pain, dyspnea, cough, and dysphagia. CT showed that the tumor was located in the posterior compartment of the chest in 7/8 cases. Tumors > 10 cm were more heterogeneous and showed cystic changes. All patients underwent posterolateral thoracotomy, and radiological follow-up showed no evidence of recurrence. Histological analysis was considered the gold standard to confirm diagnosis, along with at least one neurogenic IHC marker. In conclusion, mediastinal schwannomas are benign encapsulated tumors. According to CT, schwannomas > 10 cm show cystic degeneration more frequently. Posterolateral thoracotomy allows complete resection and is considered the surgical approach of choice.

show abstract

Mediastinal schwannoma mimicking lymph node metastasis from locally advanced breast cancer in a 18 F-FDG PET/CT study

Cited by 2 publications

References 3 publications

Retrospective Analysis of the Clinical and Image Presentation of Eight Primary Benign Mediastinal Schwannomas

Retrospective Analysis of the Clinical and Image Presentation of Eight Primary Benign Mediastinal Schwannomas

Retrospective analysis of the clinical presentation and imaging of eight primary benign mediastinal schwannomas

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