“…In 6 of the patients, an obvious cause for the pancreatitis (as was the case with our patient) was not elucidated, and in the seventh, hereditary pancreatitis was identified as the primary etiologic factor. It has been postulated that a pancreatopleural fistula can arise because of ductal (pancreatic) disruption, particularly in its posterior aspect [2]; once in the retroperitoneum, the pancreatic fluid will move along the path of least resistance, which is usually along the esophagus or aorta and into the mediastinum [5]. In this region, the fistula may be contained and present as a mediastinal pseudocyst, or more commonly, it may erode into one or both pleural spaces resulting in pleural effusions.…”